Regulation and Mechanism of Transforming Growth Factor-β1/Smads Signaling Pathway on Development of Ovaries in Mammalian
ZHOU Min1, FENG Qiang2, HUANG Libo1, YANG Zaibin1, YANG Weiren1, JIANG Shuzhen1
1. Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China;
2. Tai'an Central Hospital, Tai'an 271000, China
Abstract：The normally operation of the program within the body is depend on the coordination among different signal transduction pathways. transforming growth factor (TGF)-β1/Smads signaling pathway among numerous pathways has received increasing attention by scholars and became a research hot point in molecular and cell biology. It has been confirmed that TGF-β1/Smads signaling pathway is the indispensible way to regulate the development of ovarian follcles. In this paper, the regulatory role and mechanism of TGF-β1/Smads signaling pathway in mammalian ovarian development were reviewed in aspect of TGF-β receptor, Smads protein, bone morphogenetic protein (BMP), thrombospondin 1 (THB-S1), S-phase kinase association protein 1 (SKP1) and other regulatory mechanism. This review is aim to draw attention to the regulation of TGF-β1/Smads in ovarian development and provide some reference for the treatment of some diseases during ovarian development.
周敏, 冯强, 黄丽波, 杨在宾, 杨维仁, 姜淑贞. 转化生长因子β1/Smads信号传导通路在哺乳动物卵巢发育中的调控作用及其作用机制[J]. 动物营养学报, 2017, 29(7): 2283-2288.
ZHOU Min, FENG Qiang, HUANG Libo, YANG Zaibin, YANG Weiren, JIANG Shuzhen. Regulation and Mechanism of Transforming Growth Factor-β1/Smads Signaling Pathway on Development of Ovaries in Mammalian. Chinese Journal of Animal Nutrition, 2017, 29(7): 2283-2288.
