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动物营养学报 2017, Vol. 29 Issue (9) :3075-3082    DOI: 10.3969/j.issn.1006-267x.2017.09.008
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Toll样受体4在机体免疫中的作用机制及一些营养因子对其的影响
秦龙, 姜宁, 张爱忠, 马迪
黑龙江八一农垦大学动物科技学院, 大庆 163319
Mechanism of Toll Like Receptor 4 in Immune Function and Effects of Some Nutritional Factors on It
QIN Long, JIANG Ning, ZHANG Aizhong, MA Di
College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China
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摘要 Toll样受体4(TLR4)在机体抵御外源和内源抗原干扰方面具有重要贡献,在连接固有免疫和获得性免疫中起到桥梁作用,TLR4引导的信号通路是近年来生命科学研究的热点内容。通过研究TLR4信号通路,可深入阐明机体免疫机制。本文就近几年国内外对TLR4的研究进行分析,对其结构、分布、配体及作用机制进行综述,并对未来发展方向进行展望,以期为未来科研及医疗提供理论参考。
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关键词TLR4   信号通路   机制   免疫     
Abstract: Toll like receptor 4 (TLR4) plays important roles in resisting exogenous and endogenous antigen interference, and it is also as a bridge in the connection between innate immunity and acquired immunity. Recently, TLR4-guided signal paths have been a hotspot in immunology, it could explain the immune mechanism in the body in depth through the study of TLR4 signaling pathway. This paper presented an overview about the newest research results of TLR4 in related to the structure, distribution, ligand, mechanism, nutrition-related factors and proposed the direction for future development nationally and internationally, which will provide some references for future scientific research and medical treatment.
KeywordsTLR4,   signal pathway,   mechanism,   immunization     
收稿日期: 2017-02-24;
基金资助:

国家自然科学基金项目(31472120);黑龙江省自然科学基金项目(C201325);黑龙江省农垦总局科技攻关项目(HNK125B-12-04)

通讯作者 姜宁,教授,博士生导师,E-mail:jiangng_2008@sohu.com     Email: jiangng_2008@sohu.com
作者简介: 秦龙(1991-),男,黑龙江宝清人,硕士研究生,从事饲料资源开发与利用的研究。E-mail:byndql@163.com
引用本文:   
. Toll样受体4在机体免疫中的作用机制及一些营养因子对其的影响[J]. 动物营养学报, 2017,V29(9): 3075-3082
. Mechanism of Toll Like Receptor 4 in Immune Function and Effects of Some Nutritional Factors on It[J]. Chinese Journal of Animal Nutrition, 2017,V29(9): 3075-3082.
链接本文:  
http://www.chinajan.com/CN/10.3969/j.issn.1006-267x.2017.09.008     或     http://www.chinajan.com/CN/Y2017/V29/I9/3075
 
[1] CHATTERJEE B,BANOTH B,MUKHERJEE T,et al.Late-phase synthesis of IκBα insulates the TLR4-activated canonical NF-κB pathway from noncanonical NF-κB signaling in macrophages[J].Science Signaling,2016,9(457):ra120.
[2] BARRANCO C.Inflammation:soluble MRP8/14 recruits neutrophils via TLR4[J].Nature Reviews Rheumatology,2015,11(6):320.
[3] LAPPIN M J,BROWN V,ZARIC S S,et al.Interferon-γ stimulates CD14,TLR2 and TLR4 mRNA expression in gingival fibroblasts increasing responsiveness to bacterial challenge[J].Archives of Oral Biology,2016,61:36-43.
[4] LI X Q,ZHANG Z L,TAN W F,et al.Down-regulation of CXCL12/CXCR4 expression alleviates ischemia-reperfusion-induced inflammatory pain via inhibiting glial TLR4 activation in the spinal cord[J].PLoS One,2016,11(10):e0163807.
[5] SWAROOP S,SENGUPTA N,SURYAWANSHI A R,et al.HSP60 plays a regulatory role in IL-1β-induced microglial inflammation via TLR4-p38 MAPK axis[J].Journal of Neuroinflammation,2016,13:27.
[6] GE X,CAO Z,GU Y,et al.PFKFB3 potentially contributes to paclitaxel resistance in breast cancer cells through TLR4 activation by stimulating lactate production[J].Molecular & Cellular Biology,2016,62(6):119-125.
[7] CHANTRATITA N,TANDHAVANANT S,SEAL S,et al.TLR4 genetic variation is associated with inflammatory responses in Gram-positive sepsis[J].Clinical Microbiology and Infection,2017,23(1):47.e1-47.e10.
[8] 钟田雨,唐靖,陈登宇,等.利用荧光共振能量转移技术研究活细胞TLR4与MD-2作用结构域[J].生物化学与生物物理进展,2009,36(11):1451-1457.
[9] MCGETTRICK A F,O'NEILL L A.The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction[J].Molecular Immunology,2004,41(6/7):577-582.
[10] CIESIELSKA A,SAS-NOWOSIELSKA H,KWIATKOWSKA K.Bis (monoacylglycero) phosphate inhibits TLR4-dependent RANTES production in macrophages[J].The International Journal of Biochemistry & Cell Biology,2016,83:15-26.
[11] MOARBESS G,GUICHOU J F,PANIAGUA-GAYRAUD S,et al.New IKK inhibitors:synthesis of new imidazo[1,2-a]quinoxaline derivatives using microwave assistance and biological evaluation as IKK inhibitors[J].European Journal of Medicinal Chemistry,2016,115:268-274.
[12] 李国逊,李宁.Toll样受体在肠黏膜屏障免疫机制的研究进展[J].肠外与肠内营养,2008,15(6):366-368,372.
[13] 胡庆丰,陈同辛.防御素研究进展[J].临床儿科杂志,2015,33(9):831-834.
[14] CJOI H G,CHOI S,BACK Y W,et al.Mycobacterium tuberculosis Rv2882c protein induces activation of macrophages through TLR4 and exhibits vaccine potential[J].PLoS One,2016,11(10):e0164458.
[15] 冯丽.PrxⅠ在LPS诱导小鼠免疫反应过程中的调控作用研究[D].硕士学位论文.大庆:黑龙江八一农垦大学,2015.
[16] 沈圆圆,郭松雪.Toll样受体4抑制剂对大鼠肾缺血再灌注损伤的保护作用[J].浙江创伤外科,2015(6):1082-1085.
[17] 刘翔,林漫鹏,丁元伟,等.TLR4在益生菌治疗小鼠Hp感染中的作用[J].中国现代医学杂志.2011,21(1):32-35,40.
[18] AGOSTO L M,HIRENT J B,MICHAELS D H,et al.Porphyromonas gingivalis-mediated signaling through TLR4 mediates persistent HIV infection of primary macrophages[J].Virology,2016,499:72-81.
[19] CARTER D,FOX C B,DAY T A,et al.A structure-function approach to optimizing TLR4 ligands for human vaccines[J].Clinical & Translational Immunology,2016,5(11):e108.
[20] 周正华,马玲玲.肠易激综合征与神经-内分泌-免疫网络关系[J].中国中西医结合消化杂志,2013,21(2):106-109.
[21] BIANCHI M E.DAMPs,PAMPs and alarmins:all we need to know about danger[J].Journal of Leukocyte Biology,2007,81(1):1-5.
[22] 易宏波.抗菌肽CWA对断奶仔猪肠道炎症和肠道屏障功能的作用及其机制[D].博士学位论文.浙江:浙江大学,2016.
[23] 庞珊珊,乐颖影.Toll样受体4对饥饿代谢的调控作用[J].中国基础科学,2011,13(3):30-32.
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