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动物营养学报 2018, Vol. 30 Issue (9) :3459-3465    DOI: 10.3969/j.issn.1006-267x.2018.09.015
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Klotho蛋白对氧化应激的影响及可能机制
常雅琦1, 文敏1,2, 赵华1, 陈小玲1, 田刚1, 刘光芒1, 蔡景义1, 贾刚1
1. 四川农业大学动物营养研究所, 成都 611130;
2. 西藏职业技术学院畜牧兽医系, 拉萨 850000
Effects and Possible Mechanisms of Klotho Protein on Oxidative Stress
CHANG Yaqi1, WEN Min1,2, ZHAO Hua1, CHEN Xiaoling1, TIAN Gang1, LIU Guangmang1, CAI Jingyi1, JIA Gang1
1. Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China;
2. Tibet Vocational Technical College, Lasa 850000, China
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摘要 Klotho是一种最近发现的抗衰老基因,它的缺失或突变会导致小鼠在出生3~4周后表现出衰老现象,相反,其过表达可增强小鼠的抗氧化能力,并延长小鼠寿命。目前研究表明,Klotho蛋白发挥抗氧化应激功能可能是通过激活叉头状转录因子O(FoxO)的转录活性、激活环磷酸腺苷(cAMP)信号通路、激活Kelch样环氧氯丙烷相关蛋白-1(Keap1)-核因子E2相关因子2(Nrf2)/抗氧化反应元件(ARE)信号通路来实现的。本文就Klotho的发现、结构特征、表达及其蛋白与氧化应激之间的关系进行综述,以期为畜牧生产中缓解动物氧化应激提供思路。
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关键词Klotho蛋白   氧化应激   FoxO   cAMP   Keap1-Nrf2/ARE     
Abstract: The delection or mutation of Klotho, a newly identified anti-aging gene, can cause 3-to 4-week-old mice to show senescence. On the contrary, the overexpression of Klotho can enhance the antioxidant capacity of mice and prolong lifespan. The present study show that Klotho protein may play an antioxidant stress role by activating forkhead transcription factor O (FoxO) transcriptional activity, cyclic adenosine monophosphate (cAMP) signaling pathway and Kelch-like ECH-associated protein 1(Keap1)-nuclear factor erythroid-2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling pathway. This review summarizes the discovery, structure, expression of Klotho and the relationship between Klotho protein and oxidative stress in order to provide ideas for alleviating oxidative stress in maintaining the health of livestock and poultry.
KeywordsKlotho protein,   oxidative stress,   FoxO,   cAMP,   Keap1-Nrf2/ARE     
收稿日期: 2018-02-28;
基金资助:

四川省科技支撑计划(2013NZ0054);四川省出国留学回国人员科研活动择优项目

通讯作者 贾刚,教授,博士生导师,E-mail:jiagang700510@163.com     Email: jiagang700510@163.com
作者简介: 常雅琦(1993-),女,河南三门峡人,硕士研究生,从事饲料资源开发及高效利用研究。E-mail:464852880@qq.com
引用本文:   
. Klotho蛋白对氧化应激的影响及可能机制[J]. 动物营养学报, 2018,V30(9): 3459-3465
. Effects and Possible Mechanisms of Klotho Protein on Oxidative Stress[J]. Chinese Journal of Animal Nutrition, 2018,V30(9): 3459-3465.
链接本文:  
http://www.chinajan.com/CN/10.3969/j.issn.1006-267x.2018.09.015     或     http://www.chinajan.com/CN/Y2018/V30/I9/3459
 
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