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动物营养学报 2018, Vol. 30 Issue (9) :3466-3472    DOI: 10.3969/j.issn.1006-267x.2018.09.016
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肠道菌群与胆汁酸代谢的互作关系
范哲于1, 王进波1, 齐莉莉1, 李振彪1,2
1. 浙江大学宁波理工学院, 宁波 315100;
2. 浙江大学化学工程与生物工程学院, 杭州 310027
Interacting Relationship between Intestinal Microflora and Bile Acid Metabolism
FAN Zheyu1, WANG Jinbo1, QI Lili1, LI Zhenbiao1,2
1. Ningbo Institute of Technology, Zhejiang University, Ningbo 315100, China;
2. College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China
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摘要 肠道菌群与胆汁酸代谢密切相关,肠道细菌通过调节法尼醇受体和G蛋白偶联受体的表达影响胆汁酸的合成;肠道细菌产生的胆酸盐水解酶和类固醇脱氢酶影响胆汁酸去结合、共价修饰和异构化;肠道细菌通过影响肠黏膜胆汁酸转运载体的表达,影响胆汁酸的重吸收。胆汁酸可破坏细胞膜完整性、损伤DNA或诱导蛋白质变性失活等,从而直接抑制肠道细菌;也可通过刺激肠道上皮产生一氧化氮合酶、白细胞介素等因子,间接抑制肠道细菌的生长、增殖;胆汁酸还可作为诱导物,调节致病菌毒力因子的表达。肠道菌群和胆汁酸与畜禽健康密切相关,两者通过精细复杂的互作机制,影响机体的生理机能。本文总结了肠道菌群与胆汁酸代谢的互作关系及其在调节畜禽机体健康和生产性能过程中的作用。
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关键词肠道菌群   胆汁酸   互作   畜禽健康     
Abstract: Intestinal microflora is closely related to bile acid metabolism. Intestinal microflora affect the synthesis of bile acid by regulating expression of farnesoid X receptor and G protein-coupled receptor. The bacteria influence the deconjugation, covalent modification and epimervation of bile acid by producing bile salt hydrolases and hydroxysteroid dehydrogenase. The expression of intestinal mucosal bile acid transporters and the reabsorption of bile acid are also regulated by intestinal microflora. Bile acid can directly inhibit the intestional bacteria by destroying the integrity of the bacterial membrane, damaging the DNA, denaturing the protein. Bile acid also can indirectly suppress the growth and proliferation of intestinal bacteria by stimulating intestinal epithelium to producing inducible nitric oxide synthase and interleukin. Bile acid act as an inducer to modulate expression of virulence factors of pathogenic bacteria. The intestinal micoflora and bile acid are closely related to the animal health, which affect animal physiological functions by sophisticated mechanism. This paper reviewed the interacting relationship between intestinal microflora and bile acid metabolism, and the roles of the interaction in regulation of animal health and performance.
Keywordsintestinal microflora,   bille acid,   interaction,   animal health     
收稿日期: 2018-02-12;
基金资助:

国家自然科学基金项目(31272461,31301984);宁波市科技计划项目(2013C11031)

通讯作者 齐莉莉,讲师,硕士生导师,E-mail:qll@nit.net.cn     Email: qll@nit.net.cn
作者简介: 范哲于(1996-),男,浙江舟山人,本科生,从事肠道微生物与宿主互作机制研究。E-mail:925152995@qq.com
引用本文:   
. 肠道菌群与胆汁酸代谢的互作关系[J]. 动物营养学报, 2018,V30(9): 3466-3472
. Interacting Relationship between Intestinal Microflora and Bile Acid Metabolism[J]. Chinese Journal of Animal Nutrition, 2018,V30(9): 3466-3472.
链接本文:  
http://www.chinajan.com/CN/10.3969/j.issn.1006-267x.2018.09.016     或     http://www.chinajan.com/CN/Y2018/V30/I9/3466
 
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