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肝脏极低密度脂蛋白合成和分泌的研究进展

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  • 中国农业科学院北京畜牧兽医研究所,动物营养学国家重点实验室,北京 100193
闻治国(1985-),男,山西忻州人,硕士研究生,从事水禽营养学研究。E-mail: 373480263@qq.com

收稿日期: 2011-06-22

  网络出版日期: 2011-11-21

基金资助

现代水禽产业技术体系建设专项资金资助(ny-cytx-45)

Synthesis and Secretion of Hepatic Very Low-Density Lipoprotein: a Review

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  • State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Received date: 2011-06-22

  Online published: 2011-11-21

摘要

肝脏中极低密度脂蛋白(very low-density lipoprotein,VLDL)的过量沉积是引起脂质代谢紊乱进而形成脂肪肝的主要原因。本文综述了VLDL组装过程的最新特点以及肝脏中VLDL合成和分泌的影响因素,包括与VLDL合成相关的载脂蛋白B-100(apoB-100)的结构和功能、微粒体甘油三酯转运蛋白(microsomal triglyceride transfer protein,MTP)调节VLDL合成的作用以及其他蛋白和脂肪酸对VLDL合成的影响。同时提出了VLDL合成和分泌过程中有待进一步研究的分子和细胞机制,并且展望了VLDL在畜牧业上的应用前景。

本文引用格式

闻治国, 侯水生, 谢明, 黄苇 . 肝脏极低密度脂蛋白合成和分泌的研究进展[J]. 动物营养学报, 2011 , 23(11) : 1854 -1861 . DOI: 10.3969/j.issn.1006-267x.2011.11.002

Abstract

Excess deposition of very low-density lipoproteins (VLDL) leading to lipid metabolic disorders is the major cause of fatty liver. This review provides the latest understanding in aspects of VLDL assembly process and factors affecting hepatic VLDL synthesis and secretion, including structure-function relationships within apolipoprotein B-100 (apoB-100), role of microsomal triglyceride transfer protein (MTP) in modulating VLDL synthesis, and other hepatic proteins and fatty acids contributing to VLDL assembly. In addition, some suggestions on studying molecular and cellular mechanisms of VLDL synthesis and secretion are proposed, and the perspectives of VLDL applications in animal husbandry are also discussed.

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