ZHU Lihui, XU Jiangxiong, CHEN Xiaolian . Relationship between Apoptosis and Intestinal Functions[J]. Chinese Journal of Animal Nutrition, 2011 , 23(11) : 1862 -1869 . DOI: 10.3969/j.issn.1006-267x.2011.11.003

[1] STELLER H. Mechanisms and genes of cellular suicide[J]. Science, 1995, 267:1445-1449.

[2] MEIER P, FINCH A, EVAN G. Apoptosis in development[J]. Nature, 2000, 407:796-801.

[3] VERMEULEN K, VAN BOCKSTAELE D R, BERNEMAN Z N. Apoptosis: mechanisms and relevance in cancer[J]. Annals of Hematology, 2005, 84(10):627-639.  

[4] WYLLIE A H. Apoptosis: an overview[J]. British Medical Bulletin, 1997, 53(3):451-465.

[5] KUMAR S, VAUX D L. Apoptosis A cinderella caspase takes center stage[J]. Science, 2002, 297:1290-1291.

[6] PITTI R M, MARSTERS S A, RUPPERT S, et al. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family[J]. The Journal of Biological Chemistry, 1996, 271(22):12687-12690.  

[7] ASHKENAZI A, DIXIT V M. Death receptors: signaling and modulation[J]. Science, 1998, 281:1305-1308.

[8] NAGATA S. Apoptosis by death factor[J]. Cell, 1997,88(3):355-365.  

[9] THORNBERRY N A, LAZEBNIK Y. Caspases: enemies within[J]. Science, 1998, 281:1312-1316.

[10] ZOU H, HENZEL W J, LIU X, et al. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3[J]. Cell, 1997, 90(3):405-413.  

[11] LI P, NIJHAWAN D, BUDIHARDJO I, et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade[J]. Cell, 1997, 91(4):479-489.  

[12] LAKHANI S A, MASUD A, KUIDA K, et al. Caspases 3 and 7: key mediators of mitochondrial events of apoptosis[J]. Science, 2006, 311:847-851.

[13] NEUZIL J, WANG X F, DONG L F, et al. Molecular mechanism of 'mitocan’-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins[J]. FEBS Letters, 2006, 580(22):5125-5129.  

[14] ADAMS J M, CORY S. Bcl-2-regulated apoptosis: mechanism and therapeutic potential[J]. Current Opinion in Immunology, 2007, 19(5):488-496.  

[15] OYADOMARI S, ARAKI E, MORI M. Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells[J]. Apoptosis, 2002, 7(4):335-345.  

[16] SCORRANO L, OAKES S A, OPERFRMAN J T, et al. BAX and BAK regulation of endoplasmic reticulum Ca²⁺: a control point for apoptosis[J]. Science, 2003, 300:135-139.

[17] MAJUMDAR A P, DU J, YU Y, et al. Cell cycle and apoptosis regulatory protein-1: a novel regulator of apoptosis in the colonic mucosa during aging[J]. American Journal of Physiology, 2007, 293(6):G1215-G1222.

[18] JIMBO A, FUJITA E, KOUROKU Y, et al. ER stress induces caspase-8 activation, stimulating cytochrome c release and caspase-9 activation[J]. Experimental Cell Research, 2003, 283(2):156-166.  

[19] MARTINEZ J A, ZHANG Z, SVETLO S I, et al. Calpain and caspase processing of caspase-12 contribute to the ER stress-induced cell death pathway in differentiated PC12 cells[J]. Apoptosis, 2010, 15(12):1480-1493.  

[20] FERRI K F, KROEMER G. Organelle-specific initiation of cell death pathways[J]. Nature Cell Biology, 2001, 3(11):E255-E263.

[21] DI SANO F, FERRARO E, TUFI R, et al. Endoplasmic reticulum stress induces apoptosis by an apoptosome-dependent but caspase 12-independent mechanism[J]. The Journal of Biological Chemistry, 2006, 281(5):2693-2700.

[22] DOLAI S, PAL S, YADAV R K, et al. Endoplasmic reticulum stress-induced apoptosis in leishmania through Ca²⁺-dependent and caspase-independent mechanism[J]. The Journal of Biological Chemistry, 2011, 286(15):13638-13646.  

[23] FUJIMOTO K, IWAKIRI R, WU B, et al. Homeostasis in the small intestinal mucosa balanced between cell proliferation and apoptosis is regulated partly by the central nervous system[J]. Journal of Gastroenterology, 2002,37(Suppl. 14):139-144.

[24] BERNSTEIN H, HOLUBEC H, WARNEKE J A, et al. Patchy field defects of apoptosis resistance and dedifferentiation in flat mucosa of colon resections from colon cancer patients[J]. Annals of Surgical Oncology, 2002,9(5):505-517.  

[25] SOUZA H S, TORTORI C J, CASTELO-BRANCO M T, et al. Apoptosis in the intestinal mucosa of patients with inflammatory bowel disease: evidence of altered expression of FasL and perforin cytotoxic pathways[J]. International Journal of Colorectal Disease, 2005, 20(3):277-286.  

[26] VAN GRIEKEN N C, MEIJER G A, ZUR HAUSEN A, et al. Increased apoptosis in gastric mucosa adjacent to intestinal metaplasia[J]. Journal of Clinical Pathology, 2003, 56(5):358-361.  

[27] CUMMINS A G, THOMPSON F M. Effect of breast milk and weaning on epithelial growth of the small intestine in humans[J]. Gut, 2002,51(5):748-754.  

[28] ZABIELSKI R, GODLEWSKI M M, GUILLOTEAU P. Control of development of gastrointestinal system in neonates[J]. Journal of Physiology and Pharmacology, 2008, 59(Suppl. 1):35-54.

[29] DVORAK B, M C WILLIAM D L, WILLIAMS C S, et al. Artificial formula induces precocious maturation of the small intestine of artificially reared suckling rats[J]. Journal of Pediatric Gastroenterology and Nutrition, 2000, 31(2):162-169.  

[30] BOUDRY G, PÉRON V, HUËROU-LURON I L, et al. Weaning induces both transient and long-lasting modifications of absorptive, secretory, and barrier properties of piglet intestine[J]. The Journal of Nutrition, 2004, 134(9):2256-2262.

[31] SHAH K A, SHUREY S, GREEN C J. Apoptosis after intestinal ischemia-reperfusion injury: a morphological study[J]. Transplantation, 1997, 64(10):1393-1397.  

[32] IKEDA H, SUZUKI Y, SUZUKI M, et al. Apoptosis is a major mode of cell death caused by ischaemia and ischaemia/reperfusion injury to the rat intestinal epithelium[J]. Gut, 1998, 42(4):530-537.  

[33] HENGARTNER M O. The biochemistry of apoptosis[J]. Nature, 2000, 407:770-776.

[34] WU B, IWAKIRI R, TSUNADA S, et al. iNOS enhances rat intestinal apoptosis after ischemia-reperfusion[J]. Free Radical Biology & Medicine, 2002, 33(5):649-658.  

[35] GRANGER D N. Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury[J]. The American Journal of Physiology, 1988, 255:H1269-H1275.

[36] ABRAHAM C, CHO J H. IL-23 and autoimmunity: new insights into the pathogenesis of inflammatory bowel disease[J]. Annual Review of Medicine, 2009, 60:97-110.

[37] LEVINE A D. Apoptosis: implications for inflammatory bowel disease[J]. Inflammatory Bowel Diseases, 2000, 6(3):191-205.

[38] PEPPELENBOSCH M P, VAN DEVENTER S J. T cell apoptosis and inflammatory bowel disease[J]. Gut, 2004, 53(11):1556-1558.  

[39] KOUNTOURAS J, KOUKLAKIS G, ZAVOS C, et al. Apoptosis, inflammatory bowel disease and carcinogenesis: overview of international and Greek experiences[J]. Canadian Journal of Gastroenterology, 2003, 17(4):249-258.

[40] VELTKAMP C, ANSTAETT M, WAHL K, et al. Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNFα treatment[J]. Gut, doi:10.1136/gut.2010.217117.

[41] STURM A, LEITE A Z, DANESE S, et al. Divergent cell cycle kinetics underlie the distinct functional capacity of mucosal T cells in Crohn’s disease and ulcerative colitis[J]. Gut, 2004, 53(11):1624-1631.  

[42] STURM A, MOHR S, FIOCCHI C. Critical role of caspases in the regulation of apoptosis and proliferation of mucosal T cells[J]. Gastroenterology, 2002, 122(5):1334-1345.  

[43] INA K, ITOH J, FUKUSHIMA K, et al. Resistance of Crohno’s disease T cells to multiple apoptotic signals is associated with a Bcl-2/Bax mucosal imbalance[J]. Journal of Immunology, 1999, 163(2):1081-1090.

[44] INAGAKI-OHARA K, YADA S, TAKAMURA N, et al. p53-dependent radiation-induced crypt intestinal epithelial cells apoptosis is mediated in part through TNF-TNFR1 system[J]. Oncogene, 2001,20(7):812-818.  

[45] CHIPUK J E, KUWANA T, BOUCHIER-HAYES L, et al. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis[J]. Science, 2004, 303: 1010-1014.

[46] ALLEN R G, TRESINI M. Oxidative stress and gene regulation[J]. Free Radical Biology and Medicine 2000, 28(3):463-499.

[47] HATOUM O A, OTTERSON M F, KOPELMAN D, et al. Radiation induces endothelial dysfunction in murine intestinal arterioles via enhanced production of reactive oxygen species[J]. Arteriosclerosis, Thrombosis and Vascular Biology, 2006, 26(2):287-294.

[48] BOWEN J M, GIBSON R J, CUMMINS A G, et al. Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage[J]. Support Care Cancer, 2006, 14(7):713-731.  

[49] HAUSMANN M. How bacteria-induced apoptosis of intestinal epithelial cells contributes to mucosal inflammation[J]. International Journal of Inflammation, doi:10.4061/2010/574568

[50] 荆晓明,杨红,朱旭光,等.维生素C对百草枯中毒小鼠肺组织细胞凋亡及Bcl-2/Bax蛋白表达的影响[J].中华急诊医学杂志,2003,12(10):676-678.

[51] PANEE J, LIU W, NAKAMURA K, et al. The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation[J]. International Journal of Biological Sciences, 2007, 3(5):335-341.

[52] 杨小军,高泽,刘凯,等.谷氨酰胺对肉仔鸡肠道黏膜淋巴细胞增殖活性、氧化应激和免疫应激的调控作用[J].动物营养学报,2011,23(2):274-279.

[53] CERA K R, MAHAN D C, CROSS R F, et al. Effect of age, weaning and postweaning diet on small intestinal growth and jejunal morphology in young swine[J]. Journal of Animal Science, 1988, 66(2):574-584.