The experiment was conducted to explore the effects of corn protein polypeptides on blood physiological and biochemical indices of Changtu huoyan geese. Two hundred and forty one-day-old Changtu huoyan geese were randomly divided into four groups with six replicates each and 10 geese in each replicate. The control group was fed basal diet, and three dose groups (low-dose group, middle-dose group and high-dose group) were fed basal diets supplemented with corn protein polypeptides 100, 300 and 500 mg/kg, respectively. At 30-day-old and 60-day-old, blood samples of geese were collected for detecting the blood physiological and biochemical indices. The results showed as follows: at 30 days of age, the number of white blood cell of low-dose group was significantly higher than that of control group (P<0.05). The number of lymphocyte of high-dose group and low-dose group was significantly higher than that of control group (P<0.05). The number of median cell of middle-dose group and low-dose group was significantly higher than that of control group and high-dose group (P<0.01). The neutrophil cell count of low-dose group was significantly higher than that of other three groups (P<0.05 or P<0.01), and the neutrophil cell count of high-dose group was significantly lower than that of control group (P<0.05). The percentage of the median cell of low-dose group and middle-dose group was significantly higher than that of control group (P<0.05 or P<0.01). The serum glucose content of high-dose group was significantly lower than that of control group (P<0.01). The serum phosphorus and urea nitrogen contents of high-dose group were significantly higher than those of control group (P<0.05). The serum total bilirubin content of middle-dose group was significantly higher than that of control group (P<0.05). At 60 days of age, there was no significant difference on the all indices among four groups (P>0.05). In conclusion, the corn protein polypeptides could affect the physiological and biochemical indices, thus change the metabolism and immune function of Changtu huoyan geese.［Chinese Journal of Animal Nutrition, 2010，22（3）:702-708］