The experiment was conducted to study the effects of arginine on growth performance, immune organs indices and serum indices of weaner to 2-month-old growing meat rabbits. One hundred 1-month-old New Zealand rabbits were randomly assigned to 5 groups with 20 replicates in each group and each replicate contained 1 rabbit. Rabbits in 5 groups were fed basal diet with 0, 0.2%, 0.4%, 0.6% and 0.8% arginine, respectively. The trial lasted for 7 days for adaptation, and 23 days for sampling. The results showed that average daily gain in 0.2%～0.8% groups was significantly increased than that in control group (P<0.01), but no significant difference was found among 0.2%～0.8% groups (P>0.05). Arginine supplementation had significant influence on thymus indices (P＝0.034 5), but had no significant influence on spleen indices (P>0.05). With the increase of arginine level, IgA concentration in serum increased significantly (P<0.01), but it had no influence on IgG and IgM (P>0.05). Arginine supplementation had significant influence on total protein and cholesterol concentration in serum (P＝0.000 3, P＝0.003 4), but had no significant influence on serum urine nitrogen (P>0.05). Serum insulin concentration increased firstly and then decreased with the level of arginine increased, and the highest group was 0.4% group. Dietary arginine supplementation had significant influence on serum insulinlike growth factor1 concentration (P＝0.048 4), and the highest group was 0.2% group. In conclusion, the appropriate supplementation of arginine in diet of weaner to 2-month-old growing meat rabbit was 0.2%～0.4%.