Abstract：Host defense peptides are a kind of antibacterial cationic peptides, which are produced in living organisms. They are important parts of the nonspecific immune function of organisms. As their characteristics of broad spectrum, antibacterial, heat resistance, no residue, and non-drug resistance, host defense peptides have broad application prospects in livestock production. Overall, the role of host defense peptides in the innate immune system, the expression in the mammary gland of cows and the research progress in application of diagnosis and treatment of mastitis were reviewed in this paper, which would provide a theoretical basis for the further research and application of host defense peptides in livestock production.
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