Mitigation Mechanism of Vitamin A on Oxidative Stress in Animals
SHI Huiyu1,2, YAN Sumei1
1. College of Animal Science, Inner Mongolia Agricultural University, Huhhot 010018, China;
2. College of Animal Science and Technology, Hainan University, Haikou 570228, China
Abstract：Excessive production of arachidonic acid (ARA), reactive oxygen species and nitric oxide (NO) can cause oxidative damage in cells. Vitamin A can effectively regulate ARA and NO production and play an important role in alleviating oxidative stress. In this paper, the mitigation mechanism of vitamin A on oxidative stress of animals was reviewed from the point of views of increasing the expression and activities of selenoprotein glutathione peroxidase (GPx) and thioredoxin reductase (TrxR), and regulating the excessive production of ARA and NO via TrxR/mitogen activated protein kinase (MAPK) pathway and nuclear factor E2 related factor 2 (Nrf2)/GPx1/nuclear transcription factor-κB (NF-κB) pathway. It would provide a theoretical basis for the study of the regulation mechanism of vitamin A on oxidative stress.
石惠宇, 闫素梅. 维生素A对动物氧化应激的减缓作用机制[J]. 动物营养学报, 2019, 31(6): 2458-2464.
SHI Huiyu, YAN Sumei. Mitigation Mechanism of Vitamin A on Oxidative Stress in Animals. Chinese Journal of Animal Nutrition, 2019, 31(6): 2458-2464.
BANAN A, FIELDS J Z, DECKER H, et al.Nitric oxide and its metabolites mediate ethanol-induced microtubule disruption and intestinal barrier dysfunction[J].The Journal of Pharmacology and Experimental Therapeutics, 2000, 294(3):997-1008.
[39]
HUNG L F, LAI J H, LIN L C, et al.Retinoid acid inhibits IL-1-induced iNOS, COX-2 and chemokine production in human chondrocytes[J].Immunological Investigations, 2008, 37(7):675-693.
[46]
ABDELHAMID L, HUSSEIN H, GHANEM M, et al.Retinoic acid-mediated anti-inflammatory responses in equine immune cells stimulated by LPS and allogeneic mesenchymal stem cells[J].Research in Veterinary Science, 2017, 114:225-232.
[5]
SORDILLO L M.Selenium-dependent regulation of oxidative stress and immunity in periparturient dairy cattle[J].Veterinary Medicine International, 2013, 2013:154045.
[3]
FANG Y Z, YANG S, WU G Y.Free radicals, antioxidants, and nutrition[J].Nutrition, 2002, 18(10):872-879.
[26]
CHU F F, ESWORTHY R S, LEE L, et al.Retinoic acid induces Gpx2 gene expression in MCF-7 human breast cancer cells[J].The Journal of Nutrition, 1999, 129(10):1846-1854.
[48]
LI Q, SANLIOGLU S, LI S J, et al.GPx-1 gene delivery modulates NF-κB activation following diverse environmental injuries through a specific subunit of the IKK complex[J].Antioxidants & Redox Signaling, 2001, 3(3):415-432.
[2]
RYMAN V E, PACKIRISWAMY N, SORDILLO L M.Role of endothelial cells in bovine mammary gland health and disease[J].Animal Health Research Reviews, 2015, 16(2):135-149.
[27]
KUROSAWA T, NAKAMURA H, YAMAURA E, et al.Cytotoxicity induced by inhibition of thioredoxin reductases via multiple signaling pathways:role of cytosolic phospholipase A2α-dependent and-independent release of arachidonic acid[J].Journal of Cellular Physiology, 2009, 219(3):606-616.
[34]
SCHMIDT H H H W, WALTER U.NO at work[J].Cell, 1994, 78(6):919-925.
[40]
ERTESVAG A, AUSTENAA L M I, CARLSEN H, et al.Retinoic acid inhibits in vivo interleukin-2 gene expression and T-cell activation in mice[J].Immunology, 2009, 126(4):514-522.
MC GUIRE C, PRINZ M, BEYAERT R, et al.Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology[J].Trends in Molecular Medicine, 2013, 19(10):604-613.
[9]
JIN L, YAN S M, SHI B L, et al.Retinoic acid attenuates oxidative injury in bovine mammary epithelial cells induced by hydrogen peroxide[J].Czech Journal of Animal Science, 2017, 62(12):539-548.
[17]
BRIGELIUS-FlOHÈ R.Glutathione peroxidases and redox-regulated transcription factors[J].Biological Chemistry, 2006, 387(10/11):1329-1335.
[24]
KHAFAGA A F, EL-SAYED Y S.All-trans-retinoic acid ameliorates doxorubicin-induced cardiotoxicity:in vivo potential involvement of oxidative stress, inflammation, and apoptosis via caspase-3 and p53 down-expression[J].Naunyn-Schmiedeberg's Archives of Pharmacology, 2018, 391(1):59-70.
[29]
LIU Y M, MIN W.Thioredoxin promotes ASK1 ubiquitination and degradation to inhibit ASK1-mediated apoptosis in a redox activity-independent manner[J].Circulation Research, 2002, 90(12):1259-1266.
[32]
TAKEDA K, NAGURO I, NISHITOH H, et al.Apoptosis signaling kinases:from stress response to health outcomes[J].Antioxidants & Redox Signaling, 2011, 15(3):719-761.
[49]
TRAN T V, SHIN E J, JEONG J H, et al.Protective potential of the glutathione peroxidase-1 gene in abnormal behaviors induced by phencyclidine in mice[J].Molecular Neurobiology, 2017, 54(9):7042-7062.
[19]
SHARMA A, YUEN D, HUET O, et al.Lack of glutathione peroxidase-1 facilitates a pro-inflammatory and activated vascular endothelium[J].Vascular Pharmacology, 2016, 79:32-42.
[21]
HAWKES W C, ALKAN Z.Regulation of redox signaling by selenoproteins[J].Biological Trace Element Research, 2010, 134(3):235-251.
[30]
HOPE W C, PATEL B J, FIEDLER-NAGY C, et al.Retinoids inhibit phospholipase A2 in human synovial fluid and arachidonic acid release from rat peritoneal macrophages[J].Inflammation, 1990, 14(5):543-559.
[33]
LIN L L, WARTMANN M, LIN A Y, et al.cPLA2 is phosphorylated and activated by MAP kinase[J].Cell, 1993, 72(2):269-278.
SHI H, YAN S, JIN L, et al.Vitamin A affects the expression of antioxidant genes in bovine mammary epithelial cells with oxidative stress induced by diethylene triamine-nitric oxide polymer[J].Czech Journal of Animal Science, 2016, 61(3):117-126.
BOGDAN C, RÖLLINGHOFF M, DIEFENBACH A.Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity[J].Current Opinion in Immunology, 2000, 12(1):64-76.
[44]
CHEN X L, KUNSCH C.Induction of cytoprotective genes through Nrf2/antioxidant response element pathway:a new therapeutic approach for the treatment of inflammatory diseases[J].Current Pharmaceutical Design, 2004, 10(8):879-891.
[6]
MILLER J K, BRZEZINSKA-SLEBODZINSKA E, MADSEN F C.Oxidative stress, antioxidants, and animal function[J].Journal of Dairy Science, 1993, 76(9):2812-2823.
[20]
ARTHUR J R, BECKETT G J, MITCHELL J H.The interactions between selenium and iodine deficiencies in man and animals[J].Nutrition Research Reviews, 1999, 12(1):55-73.
[25]
SILVIS A M, MCCORMICK M L, SPITZ D R, et al.Redox balance influences differentiation status of neuroblastoma in the presence of all-trans retinoic acid[J].Redox Biology, 2016, 7:88-96.
SHI H Y, YAN S M, GUO Y M, et al.Vitamin A pretreatment protects NO-induced bovine mammary epithelial cells from oxidative stress by modulating Nrf2 and NF-κB signaling pathways[J].Journal of Animal Science, 2018, 96(4):1305-1316.
[43]
KENSLER T W, WAKABAYASHI N.Nrf2:friend or foe for chemoprevention?[J].Carcinogenesis, 2010, 31(1):90-99.
[4]
JOZWIK A, KRZYZEWSKI J, STRZALKOWSKA N, et al.Relations between the oxidative status, mastitis, milk quality and disorders of reproductive functions in dairy cows-a review[J].Animal Science Papers and Reports, 2012, 30(4):297-307.
[8]
LEBLANC S J, HERDT T H, SEYMOUR W M, et al.Peripartum serum vitamin E, retinol, and beta-carotene in dairy cattle and their associations with disease[J].Journal of Dairy Science, 2004, 87(3):609-619.
[11]
SHI H Y, YAN S M, GUO Y M, et al.The pre-protective effect of vitamin A on LPS-induced oxidative stress of bovine mammary epithelial cells[J].Italian Journal of Animal Science, 2018, 17(4):959-966.
[16]
高建忠, 黄克和.动物硒蛋白研究进展[J].畜牧与兽医, 2004, 36(7):39-42.
[22]
BRUZELIUS K, SUNDLER R, PAGMANTIDIS V, et al.Regulation of selenoprotein mRNA expression by hormones and retinoic acid in bovine mammary cells[J].Journal of Trace Elements in Medicine and Biology, 2010, 24(4):251-256.
JIN L, YAN S, SHI B, et al.Effects of retinoic acid on the synthesis of selenoprotein and the antioxidative indices of bovine mammary epithelial cells in vitro[J].Czech Journal of Animal Science, 2016, 61(4):194-202.
[28]
BRUZELIUS K, PURUP S, JAMES P, et al.Biosynthesis of selenoproteins in cultured bovine mammary cells[J].Journal of Trace Elements in Medicine and Biology, 2008, 22(3):224-233.
JIN L, YAN S M, SHI B L, et al.Effects of vitamin A on the milk performance, antioxidant functions and immune functions of dairy cows[J].Animal Feed Science and Technology, 2014, 192:15-23.
YANG W, SHEN Y M, WEI J, et al.MicroRNA-153/Nrf-2/GPx1 pathway regulates radiosensitivity and stemness of glioma stem cells via reactive oxygen species[J].Oncotarget, 2015, 6(26):22006-22027.
[50]
TAN K P, KOSUGE K, YANG M D, et al.NRF2 as a determinant of cellular resistance in retinoic acid cytotoxicity[J].Free Radical Biology and Medicine, 2008, 45(12):1663-1673.
