Research Progresses on Nutrition Metabolism and Physiological Function of Uridine Monophosphate
LI Biao1, WU Xin1,2, ZHANG Bin1, YIN Yulong1,2
1. Hunan Co-Innovation Center of Safety Animal Production, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China;
2. Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha 410125, China
Abstract：Uridine monophosphate is the most abundant nucleotide among the five nucleotides (uridine monophosphate, cytidine monophosphate, inosine monophosphate, guanosine monophosphate and adenosine monophosphate) in sow's milk, and it is more than 90% of total nucleotides in sow's milk. Compared with the sow's milk, the content of uridine monophosphate in creep feeds is the most lacking, and this phenomenon is evident especially in the early weaning stage. Therefore, uridine monophosphate may play important roles in the normal growth and development of piglets. As a basic pyrimidine nucleotide compound, uridine monophosphate has very important physiological functions. This paper reviews the structure, absorption and metabolism, biological functions, metabolism relationship with three major nutrients and potential application in animal production and so on, aims to providing reference for single nucleotide supplementation to diets for animals and single nucleotide nutrition.
李彪, 吴信, 张彬, 印遇龙. 尿苷酸的营养代谢与生理功能研究进展[J]. 动物营养学报, 2019, 31(6): 2487-2494.
LI Biao, WU Xin, ZHANG Bin, YIN Yulong. Research Progresses on Nutrition Metabolism and Physiological Function of Uridine Monophosphate. Chinese Journal of Animal Nutrition, 2019, 31(6): 2487-2494.
TSUJINAKA T, KISHIBUCHI M, ⅡJIMA S, et al.Nucleotides and intestine[J].Journal of Parenteral and Enteral Nutrition, 1999, 23(Suppl.5):S74-S77.
[18]
SAVAIANO D A, CLIFFORD A J.Adenine, the precursor of nucleic acids in intestinal cells unable to synthesize purines de novo[J].The Journal of Nutrition, 1981, 101(10):1816-1822.
[41]
JURÁNEK I, BEZEK S.Controversy of free radical hypothesis:reactive oxygen species-cause or consequence of tissue injury?[J].General Physiology and Biophysics, 2005, 24(3):263-278.
[32]
TORRES-LÍPEZ M, FERNANDEZ I, FONTANA L, et al.Influence of dietary nucleotides on liver structural recovery and hepatocyte binuclearity in cirrhosis induced by thioacetamide[J].Gut, 1996, 38(2):260-264.
[36]
BAILEY C J.Orotic aciduria and uridine monophosphate synthase:a reappraisal[J].Journal of Inherited Metabolic Disease, 2009, 32(Suppl.1):227-233.
[39]
CARVER J D, STROMQUIST C I.Dietary nucleotides and preterm infant nutrition[J].Journal of Perinatology, 2006, 26(7):443-444.
[10]
PALOMBO J D, BOWERS J L, CLOUSE M E, et al.Hepatic utilization of exogenous nucleotide precursors for restoration of ATP after cold ischemia in rats[J].The American Journal of Clinical Nutrition, 1993, 57(3):420-427.
[21]
QUAN R, UAUY R.Nucleotides and gastrointestinal development[J].Seminars in Pediatric Gastroenterology and Nutrition, 1991, 2:3-6.
JYONOUCHI H, SUN S N, WINSHIP T, et al.Dietary ribonucleotides modulate type 1 and type 2 T-helper cell responses against ovalbumin in young BALB/cJ mice[J].The Journal of Nutrition, 2001, 131(4):1165-1170.
[46]
LI B, ZHOU H, WU X, et al.Effects of dietary supplementation with uridine monophosphate on performance and intestinal morphology of weanling piglets[J].Journal of Animal Science, 2016, 94(Suppl.3):82-86.
[2]
TONINI B, FUSI E, RIZZI R, et al.Nucleotides in canine colostrum and milk at different stages of lactation[J].Archives of Animal Nutrition, 2010, 64(4):337-341.
[14]
BOZA J.Nucleotides in infant nutrition[J].Monatsschrift Kinderheilkunde, 1998, 146(Suppl.1):S39-S48.
CARVER J D, ALLAN WALKER W.The role of nucleotides in human nutrition[J].The Journal of Nutritional Biochemistry, 1995, 6(2):58-72.
[26]
SONODA T, TATIBANA M.Metabolic fate of pyrimidines and purines in dietary nucleic acids ingested by mice[J].Biochimica et Biophysica Acta:Nucleic Acids and Protein Synthesis, 1978, 521(1):55-66.
[34]
RAMIREZ M, HORTELANO P, BOZA J Jr, et al.Effect of dietary nucleotides and orotate on the blood levels of prostacyclin (PGI2) and thromboxane (TXA2) in the weanling rat[J].Prostaglandins, Leukotrienes and Essential Fatty Acids, 1991, 43(1):49-54.
[49]
UAUY R, STRINGEL G, THOMAS R, et al.Effect of dietary nucleosides on growth and maturation of the developing gut in the rat[J].Journal of Pediatric Gastroenterology and Nutrition, 1990, 10(4):497-503.
[8]
LELEIKO N S, WALSH M J, ABRAHAM S.Gene expression in the intestine:the effect of dietary nucleotides[J].Advances in Pediatrics, 1994, 42:145-169.
[12]
CHITRA R, RANJAN-CHOUDHURY R, RAMANADHAM M.Hydrogen bonding in the neutron structure of the mononucleotide 5'-UMP disodium salt[J].Applied Physics A, 2002, 74(Suppl.1):s1576-s1578.
MATEO C D, DAVE R I, STEIN H H.Effects of supplemental nucleosides for newly weaned pigs[J].Journal of Animal Science, 2004, 82(Suppl.2):71.
[7]
TSUJINAKA T, KISHIBUCHI M, ⅡJIMA S, et al.Nucleotides and intestine[J].Journal of Parenteral and Enteral Nutrition, 1999, 23(Suppl.5):S74-S77.
[28]
CARTER-SU C, KIMMICH G A.Membrane potentials and sugar transport by ATP-depleted intestinal cells:effect of anion gradients[J].The American Journal of Physiology, 1979, 237(1):C67-C74.
[38]
LE T T, ZIEMBA A, URASAKI Y, et al.Disruption of uridine homeostasis links liver pyrimidine metabolism to lipid accumulation[J].Journal of Lipid Research, 2013, 54(4):1044-1057.
[43]
GRIMBLE G K, WESTWOOD O M.Nucleotides as immunomodulators in clinical nutrition[J].Current Opinion in Clinical Nutrition and Metabolic Care, 2001, 4(1):57-64.
[50]
PEREZ-PARDO P, DODIYA H B, BROERSEN L M, et al.Gut-brain and brain-gut axis in Parkinson's disease models:effects of a uridine and fish oil diet[J].Nutritional Neuroscience, 2018, 21(6):391-402.
[1]
HO C Y, MILLER K V, SAVAIANO D A, et al.Absorption and metabolism of orally administered purines in fed and fasted rats[J].The Journal of Nutrition, 1979, 109(8):1377-1382.
[3]
MATEO C D, PETERS D N, STEIN H H.Nucleotides in sow colostrum and milk at different stages of lactation[J].Journal of Animal Science, 2004, 82(5):1339-1342.
[9]
CARVER J D.Dietary nucleotides:cellular immune, intestinal and hepatic system effects[J].The Journal of Nutrition, 1994, 124(Suppl.1):144S-148S.
[11]
LOPEZ-NAVARRO AT, GIL A, SÁNCHEZ-POZO A.Age-related effect of dietary nucleotides on liver nucleic acid content in rats[J].Annals of Nutrition and Metabolism, 1997, 41(5):324-330.
[15]
CHU S.Nucleotides:biochemistry and metabolism[J].Seminars in Pediatric Gastroenterology and Nutrition, 1991, 2:6-11.
[19]
GIL A, UAUY R.Nucleotides and related compounds in human and bovine milks[M]//JENSEN R G.Handbook of milk composition.San Diego:Academic Press, Inc, 1995:436-464.
[20]
SANDERSON I R, HE Y.Nucleotide uptake and metabolism by intestinal epithelial cells[J].The Journal of Nutrition, 1994, 124(Suppl.1):131S-137S.
[25]
BRONK J R, HASTEWELL J G.The transport of pyrimidines into tissue rings cut from rat small intestine[J].The Journal of Physiology, 1987, 382(1):475-488.
[35]
BOZA J, JIMENEZ J, FAUS M J, et al.Influences of postnatal age and dietary nucleotides on plasma fatty acids in the weanling rat[J].Journal of Parenteral and Enteral Nutrition, 1992, 16(4):322-326.
[37]
CANSEV M, WATKINS C J, VAN DER BEEK E M, et al.Oral uridine-5'-monophosphate (UMP) increases brain CDP-choline levels in gerbils[J].Brain Research, 2005, 1058(1-2):101-108.
[40]
KULKARNI A D, FANSLOW W C, RUDOLPH F B, et al.Effect of dietary nucleotides on response to bacterial infections[J].Journal of Parenteral and Enteral Nutrition, 1986, 10(2):169-171.
[6]
ADJEI A A, JONES J T, ENRIQUEZ F J, et al.Dietary nucleosides and nucleotides reduce Cryptosporidium parvum infection in dexamethasone immunosuppressed adult mice[J].Experimental parasitology, 1999, 92(3):199-208.
[17]
UAUY R.Dietary nucleotides and requirements in early life[M]//LEBENTHAL E.Textbook of gastroenterology and nutrition in infancy.New York:Raven Press, 1989:265-280.
[22]
MORLEY D J, HAWLEY D M, ULBRIGHT T M, et al.Distribution of phosphodiesterase Ⅰ in normal human tissues[J].Journal of Histochemistry & Cytochemistry, 1987, 35(1):75-82.
[23]
WEICKMANN J L, ELSON M, GLITZ D G.Purification and characterization of human pancreatic ribonuclease[J].Biochemistry, 1981, 20(5):1272-1278.
[24]
HOLDSWORTH G, COLEMAN R.Enzyme profiles of mammalian bile[J].Biochimica et Biophysica Acta:Biomembranes, 1975, 389(1):47-50.
[27]
SCHWENK M, HEGAZY E, DEL PINO V L.Uridine uptake by isolated intestinal epithelial cells of guinea pig[J].Biochimica et Biophysica Acta:Molecular Cell Research, 1984, 805(4):370-374.
[13]
COSGROVE M.Perinatal and infant nutrition.Nucleotides[J].Nutrition, 1998, 14(10):748-751.
