Research Progress on Lipopolysaccharide-Induced Intestinal Barrier Signaling Pathway
WANG Mengzhu1,2, JIA Junfeng1, CUI Yizhe1, WANG Qiuju1
1. College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China;
2. Key Laboratory of Animal Nutrition and Feed Science in South China of Ministry of Agriculture, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China
Abstract：Lipopolysaccharide(LPS)is a stressor that induces intestinal mucosal damage. It not only damages the intestine but also causes bacterial translocation. The damaged gastrointestinal barrier causes abnormal expression of tight junction proteins in the intestine, allowing endotoxin and pathogens to pass through. LPS induces the activation of nuclear factor-κB (NF-κB) signaling pathway through the Toll-like 4 receptor (TLR4) on cellular surface, then releases proinflammatory cytokine which aggravates the damage of intestine. This paper focus on the role of LPS in the processing of inflammation induction and its underlying pathways.
王梦竹, 贾军峰, 崔一喆, 王秋菊. 脂多糖诱导的肠屏障蛋白及其信号通路研究进展[J]. 动物营养学报, 2020, 32(5): 2060-2065.
WANG Mengzhu, JIA Junfeng, CUI Yizhe, WANG Qiuju. Research Progress on Lipopolysaccharide-Induced Intestinal Barrier Signaling Pathway. Chinese Journal of Animal Nutrition, 2020, 32(5): 2060-2065.
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