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儿茶素的生物学活性及其应用前景概述

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  • (1.饲料安全与高效利用教育部工程研究中心,长沙410128; 2.国家植物功能成分利用工程技术研究中心,长沙410128)
崔志杰(1989—),男,河南商丘人,硕士研究生,研究方向为饲料资源开发与利用。E-mail: 1013513928@qq.com

网络出版日期: 2011-10-24

基金资助

国家植物功能成分利用工程技术研究中心开放课题;湖南省高校科技创新团队资助计划;湖南省大学生研究性学习和创新性实验计划项目(SCX1111)

Catechin: Biological Activity and Application Potential

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  • (1.Engineering Research Center for Feed Safe and Efficient Utilization Ministry of Education, Changsha 410128, China;2. National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, Changsha 410128, China)

Online published: 2011-10-24

摘要

应激特别是氧化应激损伤会导致机体免疫功能低下、肠道结构损伤和微生态失衡。茶类提取物中的儿茶素在抗氧化、清除自由基、抗过敏、抗菌消炎、增强免疫功能等方面均具有明显的效果。通过综述其在上述领域的研究进展,为减轻机体应激创伤寻求新的营养调控措施,为寻求抗生素的替代性产品提供参考。

本文引用格式

崔志杰,何玲,刘仲华,范志勇,张石蕊,王超然,易玉,张云倩 . 儿茶素的生物学活性及其应用前景概述[J]. 动物营养学报, 2011 , 23(10) : 1664 -1668 . DOI: 10.3969/j.issn.1006-267x.2011.10.004

Abstract

Stress, especially oxidative stress injury can cause immune dysfunction, intestinal structural damage and micro-ecological imbalance. Catechin in the tea extracts had some effects on anti-oxidant, scavenging free radical, anti-anaphylaxis, antisepticize, dephlogisticate and enhancing immune function. Those biological roles were reviewed in this paper in order to provide some references for finding new nutritional regulation measures and seeking the antibiotic substitutes.[Chinese Journal of Animal Nutrition, 2011, 23(10):1664 -1668]

参考文献

[1]BERNABUCCI U, RONCHI B, LACETERA N, et al. Influence of body condition score on relationships between metabolic status and oxidative stress in periparturient dairy cows[J]. Journal of Dairy Science, 2005, 85:2173-2179.

[2]方允中,郑容梁.自由基生物学的理论与应用[M].北京:科学出版社,2002:24-28.

[3]华德兴,许晓玲,彭青,等.表儿茶素没食子酸酯与四环素协同抗金黄色葡萄球菌作用及机制[J].中国新药与临床杂志,2009,28(12):935-939.

[4]BANDYOPADHYAY D, CHATTERJEE T K, DASGUPTA A, et al. In vitro and in vivo antimicrobial action of tea: the commonest beverage of Asia[J]. Biological and Pharmaceutical Bulletin, 2005, 28(11):2125-2127.

[5]YAMAZAKI T, KISHIMOTO T, SHIGA S, et al. Biosynthesized tea polyphenols inactivate chlamydia trachomatis in vitro[J]. Antimicrobial Agents and Chemotherapy, 2005, 9(6):2501-2503.

[6]LANNING J, ROBERTS J C. Analysis of catechin content of commercial green tea products[J]. Herb Pharmcother, 2003, 3:19-32.

[7]HENNING SMMOL L, FAJARDO-LI C, LEE H W, et al. Catechin content of 18 teas and a green tea extract supplement correlates with then antioxidant capacity[J]. Nutrition Cancer, 2003, 45:226-235.

[8]LINIPSKIC A, LOMBARDO F, DOMINY B W, et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings[J]. Advantage Drug Delivery Reviews, 2001, 46:3-26.

[9]宋立人,洪询,丁绪亮,等.现代中药学大词典[M].1版.北京:人民卫生出版社,2001:1624.

[10]OKUSHIO K, MATSUMOTO N, KOHRI T,et al. Aborption of (-)-epigallocatechin gallate into rat portal vein[J]. Biological and Pharmaceutical Bulletin, 1995, 18(1):190-196.

[11]SUGANUMA M, OKABE S, ONIYAMA M, et al. Wide distribution of [3H]-(-)-epigallocatechin-3-gallate, a cancer preventive tea polyphenol, in mouse tissue[J]. Carcinogen, 1998, 19(10):1771-1776.

[12]SCALBERT A, WILLIAMSON G. Dietary intake and bioavailability of polyphenols[J]. The Journal of Nutrition, 2000, 130:2073S-2085S.

[13]MENG X, LEE M J, LI C, et al. Formation and identification of 4’-O-methyl-(-)epigallocatechin in humans[J]. Drug Metabolism and Disposition, 2001, 29:789-793.

[14]MENG X, SANG S, ZHU N, et al. Identification and characterization of methylated and ring-fission metabolites of tea catdchins formed in humans, mice, and rats[J]. Chemical Research in Toxicology, 2002, 15:1042-1050.

 [15]MANACH C, WILLIAMSON G, MORAND C, et al. Polyphenols: food sources and bioavailability [J]. The American Journal of Clinical Nutrition, 2004, 79:727-747.

[16]AMELSVOORT J M, HOF K H, MATHOT J N, et al. Plasma concentrations of individual tea catechins after a single oral dose in humans[J]. Xeinobiotica, 2001, 31:891-901.

[17]YOSHIOKA H, AKAI G, YOSHINAGE K. Protecting effect of a green tea percolate and its main constituents against gamma ray-induced scission of DNA[J]. Bioscience Biotechnology and Biochemistry,  1996, 60:117-119.

[18]KIMURA M, UMEGAKI K, KASUYA Y, et al. The relation between single double or repeated tea catechin ingestions and plasma antioxidant activity in humans[J]. European Journal of Clinical Nutrition, 2002, 12(56):1186-1193.

[19]LEENEN R, ROODENBURG A J C, TIJBURG L B M, et al. A single dose of tea with or without milk increases plasma antioxidant activity in humans[J]. European Journal of Clinical Nutrition, 2000, 54(1):87-92.

[20]杨贤强,沈生荣,候京武,等.(-)表没食子儿茶素没食子酸酯对活性氧自由基的清除作用机制[J].中国药理学通报,1994,4:16-18.

[21]GUO Q, ZHAO B L, SHEN S R, et al. ESR study on the structure-antioxidant activity relationship of tea catechins and their epimers[J]. Biochimica et Biophysica Acta, 1999, 1427:13-23.

[22]ONO K, TAKABAYSHI F, KISHIDO T, et al. Suppressive effect of green tea catechins on morphologic and functional regression of the brain in aged mice with accelerated senescence (SAMP 10)[J]. Geronto, 2004, 39:1027-1034.

[23]刘兆金,侯振平,黄瑞林,等.儿茶素对断奶仔猪生长性能和免疫器官的影响[J].华北农学报,2006,1(3):133-136.

[24]TAKABAYASHI F, HARADA  N, YAMADA M, et al. Inhibitory effect of green tea catechins in combination with sucralfate on Helicobacter pylori infection in Mongolian gerbils[J]. Journal of Gastroenterology, 2004, 9(1):61-63.

[25]李春美.茶儿茶素氧化聚合物及其生物活性的研究[D]. 博士学位论文.武汉:华中农业大学,2000:81-83.

[26]刘湘新,林亲录,施兆鹏,等.儿茶素和表儿茶素对小白鼠血清脂质的影响[J].湖南农业大学学报,2002,8(3):232-233.

[27]刘屏,王东晓,陈若芸,等.儿茶素对骨髓细胞周期及造血生长因子基因表达的作用[J].药学学报,2004,39(6):424-428.
 
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