本试验旨在研究不同剂量载铜纳米壳聚糖（CNP-Cu）对断奶仔猪生长性能、免疫和抗氧化指标的影响。选择108头平均体重(7.20±0.81) kg的21日龄“杜×长×大”三元杂交断奶仔猪，随机分成6组，每组3个重复，每个重复6头猪。对照组饲喂基础饲粮；抗生素组在基础饲粮中添加100 mg/kg金霉素；试验Ⅰ、Ⅱ、Ⅲ、Ⅳ组在基础饲粮中分别添加50、100、150、200 mg/kg的CNP-Cu。试验期28 d。饲养试验结束后，前腔静脉采血制血清，测定免疫及抗氧化指标。结果表明：1）饲粮中添加CNP-Cu能提高仔猪平均日采食量和平均日增重，降低料重比，降低腹泻率，以100 mg/kg剂量组的作用效果最佳（P<0.05）；2）饲粮中添加CNP-Cu能显著提高断奶仔猪血清补体C3水平、谷胱甘肽过氧化物酶活性和总抗氧化能力（P<0.05）。结果提示，饲粮中添加载铜纳米壳聚糖能提高断奶仔猪的免疫和抗氧化机能，提高生长性能，降低腹泻率，具有替代抗生素的潜在应用价值。
The study was conducted to investigate the effect of dietary chitosan nanopartides loaded copper (CNP-Cu) on growth performance, immunity and antioxidant indices of weaned piglets. A total of 108 21-day-old three way cross (Duroc×Landrace×Yorkshine) weaned piglets with an initial average body weight of (7.20±0.81) kg were randomly assigned into 6 groups with 3 replicates per group and 6 piglets per replicate. The piglets in control group were fed basal diet; Piglets in chlortetracycline (CTC) group were fed the basal diet supplemented with 100 mg/kg CTC, and piglets in four trial groups （Ⅰ, Ⅱ, Ⅲ and Ⅳ） were fed the basal diet supplemented with 50, 100, 150 and 200 mg/kg CNP-Cu, respectively. The experiment lasted for 28 days. After termination of the feeding trial, blood samples were collected from anterior vena cava of all piglets for serum indices analysis. The results showed as follows: 1) supplementation of CNP-Cu increased average daily feed intake and average daily gain, and decreased feed gain ratio and diarrhea rate, and the optimal supplemental level of CNP-Cu was 100 mg/kg (P<0.05). 2) Serum complement component 3, glutathione peroxidase activity and total antioxidant capacity were significantly increased with the supplementation of CNP-Cu (P<0.05). These results suggest that supplemental CNP-Cu has beneficial effects on immune and antioxidant function in weaned pigs, which also can increase growth performance and decrease diarrhea rate. Accordingly, CNP-Cu has a potential to substitute antibiotics.［Chinese Journal of Animal Nutrition, 2011, 23（10）：1806 -1811］
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