综述

瘦素及其受体对肌肉组织蛋白质代谢的调节

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  • 四川农业大学动物营养研究所,雅安 625014
毛湘冰(1980—),男,湖南长沙人,讲师,博士,从事动物营养与饲料科学的研究。E_mail: acatmxb2003@163.com

收稿日期: 2011-06-10

  网络出版日期: 2011-12-14

基金资助

四川省教育厅青年基金项目"瘦素通过PI3K-Akt-mTOR信号通路调节C2C12肌管蛋白质代谢的研究"(10ZB040)

Leptin and Leptin Receptor: Regulation of Protein Metabolism in Muscle

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  • Institute of Animal Nutrition, Sichuan Agricultural University, Ya'an 625014, China

Received date: 2011-06-10

  Online published: 2011-12-14

摘要

近年来,体内外试验研究表明,瘦素的短期或长期处理能够调节哺乳动物骨骼肌和肌细胞内蛋白质的代谢,而这主要是由于瘦素可以调节肌细胞内与蛋白质代谢相关的信号通路(如胰岛素相关信号通路和丝裂原活化蛋白激酶信号通路)的活性。因此,本文综述了瘦素及其受体在动物体内肌肉组织蛋白质代谢过程中的调节作用,并分析讨论了这一过程中瘦素的可能作用机制,为营养物质通过激素调节蛋白质代谢的深入研究及其应用提供参考。

本文引用格式

毛湘冰, 陈代文, 余冰, 黄志清 . 瘦素及其受体对肌肉组织蛋白质代谢的调节[J]. 动物营养学报, 2011 , 23(12) : 2048 -2052 . DOI: 10.3969/j.issn.1006-267x.2011.12.002

Abstract

Recent in vivo and in vitro studies showed that the protein metabolism of skeletal muscle and muscular cells could be regulated by long-and short-term treatment of leptin, which was derived from leptin regulating the intracellular signaling pathway, such as the insulin-induced pathway and MAPK pathway. The present paper reviews the rules and mechanisms of leptin and leptin receptor regulating protein metabolism of muscle and muscular cells.

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