石文标 , 谢明 , 侯水生 , 黄苇 , 喻俊英 . 维生素D生物学效价研究的一些新进展[J]. 动物营养学报, 2012 , (11) : 2079 -2084 . DOI: 10.3969/j.issn.1006-267x.2012.11.002

[1] AMMERMAN C B,BAKER D H,LEWIS A J.Bioavailability of nutrients for animals:amino acids,minerals,and vitamins[M].London:Academic Press,1995:5-7.

[2] VERSTUYF A,CARMELIET G,BOUILLON R,et al.Vitamin D:a pleiotropic hormone[J].Kidney International,2010,78(2):140-145.

[3] CLAUSEN I,JAKOBSEN J,LETH T,et al.Vitamin D₃ and 25-hydroxyvitamin D₃ in raw and cooked pork cuts[J].Journal of Food Composition and Analysis,2003,16(5):575-585.

[4] MAFF.Food Surveillance information sheet,determination of 25-OH vitamin D in selected foodstuffs.London:MAFF,1997:101.

[5] ARMAS L,HOLLIS B,HEANEY R P.Vitamin D₂ is much less effective than vitamin D₃ in humans[J].Journal of Clinical Endocrinol Metabolites,2004,89:5387-5391.

[6] BIANCUZZO R M,YOUNG A,HOLICK M F,et al.Fortification of orange juice with vitamin D₂ or vitamin D₃ is as effective as an oral supplement in maintaining vitamin D status in adults[J].American Journal of Clinical Nutrition,2010,91(6):1621-1626.

[7] WINTER M,MORAVA E,SIMON G,et al.The effect of vitamin D₃ and 25-hydroxycholecalciferol on intestinal transport of calcium in vivo and in vitro[J].Biomedical and Life Sciences:Cellular and Molecular Life Sciences,1972,28(6):659-660.

[8] BOYLE I T,OMDAHL J L,GRAY R W,et al.Biological-activity and metabolism of 24,25-dihydroxyvitamin-D[J].Journal of Biological Chemistry,1973,248:4174-4180.

[9] NORMAN A W,HENRY H.1,25-dihydroxycholecalciferol-a hormonally active form of vitamin D[J].Recent Progress in Hormone Research,1974,30:431-480.

[10] MIRAVET L,REDEL J,CARRE M,et al.Biological-activity of synthetic 25,26-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol in vitamin-D-deficient rats[J].Calcified Tissue Research,1976,21(3):145-152.

[11] DUSSO A S,BROWN A J,SLATOPOLSKY E.Vitamin D[J].American Journal of Physiology: Renal Physiology,2005,289(1):F8-F28.

[12] POWE C E,RICCIARDI C,BERG A H,et al.Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship[J].Journal of Bone Mineral Response,2011,26:1609-1616.

[13] CHUN R F,PEERCY B E,ADAMS J S,et al.Vitamin D binding protein and monocyte response to 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D:analysis by mathematical modeling[J].PLoS One,2012,7(1):e30773.doi:10.1371/journal.pone.0030773.

[14] GALLIENI M,COZZOLINO M,FALLABRINO G,et al.Vitamin D:physiology and pathophysiology[J].International Journal of Artificial Organs,2009,32:87-94.

[15] POSNER G H,SUH B C,PETERSEN K S,et al.Difluoromethyl analogs of the natural hormone 1,25-dihydroxyvitamin D₃:design,synthesis,and preliminary biological evaluation[J].Journal of Steroid Biochemistry,2007,103(3/4/5):213-221.

[16] OVES D,FERNANDEZ S,FERRERO M,et al.Versatile synthesis and biological evaluation of 1,3-diamino-substituted 1α,25-dihydroxyvitamin D₃ analogues[J].Bioorganic & Medicinal Chemistry,2006,14(4):928-937.

[17] SAITO N,SUHARA Y,ABE D,et al.Synthesis of 2α-propoxy-1α,25-dihydroxyvitamin D₃ and comparison of its metabolism by human CYP24A1 and rat CYP24A1[J].Bioorganic & Medicinal Chemistry,2009,17(13):4296-4301.

[18] CHENG J B,LEVINE M A,BELL N H,et al.Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase[J].Proceedings of the National Academy of Sciences of the United States of America,2004,101:7711-7715.

[19] VIETH R.Vitamin D supplementation 1,25-hydroxyvitamin D concentrations,and safety[J].American Journal of Clinical Nutrition,1999,69:842-856.

[20] BISCHOFF H A,GIOVANNUCCI E,WILLETT W C,et al.Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes[J].American Journal of Clinical Nutrition,2006,84:18-28.

[21] TANGPRICHA V,PEARCE E N,HOLICK M F.Vitamin D insufficiency among free-living healthy young adults[J].American Journal of Medicine,2002,112:659-662.

[22] GROSSMANN R E,TANGPRICHA V.Evaluation of vehicle substances on vitamin D bioavailability:a systematic review[J].Molecular Nutrition & Food Research,2010,54:1055-1061.

[23] OMDAHL J L,MORRIS H A,MAY B K.Hydroxylase enzymes of the vitamin D pathway:expression,function,and regulation[J].Annual Review of Nutrition,2002,22:139-166.

[24] AJIBADE D V,DHAWAN P,CHRISTAKOS S.Calcitonin:a regulator of the 25-hydroxyvitamin D₃ 1alpha hydroxylase gene[J].Journal of Bone and Mineral Research,2009 284(17):11059-11069.

[25] STOFFELS K,OVERBERGH L,BOUILLON R,et al.Immune regulation of 1alpha-hydroxylase in murine peritoneal macrophages:unravelling the IFNgamma pathway[J].Journal of Steroid Biochemistry and Molecular Biology,2007,103:567-571.

[26] ESTEBAN L,VIDAL M,DUSSO A.1alpha-hydroxylase transactivation by gamma-interferon in murine macrophages requires enhanced C/EBPbeta expression and activation[J].Journal of Steroid Biochemistry and Molecular Biology,2004,89/90:131-137.

[27] NOVAKOVIC B,SIBSON M,NG H K,et al.Placenta-specific methylation of the vitamin D 24-hydroxylase gene:implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface[J].Journal of Biological Chemistry,2009,284:14838-14848.

[28] DHAWAN P,PENG X,SUTTON A L,et al.Functional cooperation between CCAAT/enhancer-binding proteins and the vitamin D receptor in regulation of 25-hydroxyvitamin D₃ 24-hydroxylase[J].Molecular and Cellular Biology,2005,25:472-487.

[29] CHRISTAKOS S,DHAWAN P,SHEN Q,et al.New insights into the mechanisms involved in the pleiotropic actions of 1,25-dihydroxyvitamin D₃[J].Annals of the New York Academy of Sciences,2006,1068:194-203.

[30] ZHONG Y,CHRISTAKOS S.Novel mechanism of vitamin D receptor (VDR) activation: histone H3 lysine 9 methyltransferase is a transcriptional coativator for VDR[J].Journal of Bone and Mineral Research,2007,22(Suppl.1):S8.

[31] KUROSU H,OGAWA Y,MIYOSHI M,et al.Regulation of fibroblast growth factor-23 signaling by klotho[J].Journal of Biological Chemistry,2006,28:6120-6123.

[32] CHRISTAKOS S,DARE V A,DHAWAN P,et al.Vitamin D:metabolism[J].Endocrinology and Metabolism Clinics of North America,2010,39(2):243-253.

[33] MATKOVITS T,CHRISTAKOS S.Variable in vivo regulation of rat vitamin D-dependent genes (osteopontin,Ca,Mg-adenosine triphosphatase, and 25-hydroxyvitamin D₃ 24-hydroxylase):implications for differing mechanisms of regulation and involvement of multiple factors[J].Endocrinology,1995,136:3971-3982.

[34] WORTSMAN J,MATSUOKA L Y,HOLICK M F.Decreased bioavailability of vitamin D in obesity[J].American Journal of Clinical Nutrition,2000,72:690-693.

[35] CALVO M S,GARTHOFF L H,DREHER M,et al.Vitamin D₂ from light-exposed edible mushrooms is safe,bioavailable and effectively supports bone growth in rats[J].Osteoporosis International,2012.doi:10.1007/s00198-012-1934-9.

[36] PILZ S,KIENREICH K,DANIEL S,et al.Associations of sun exposure with 25-hydroxyvitamin D and parathyroid hormone levels in a cohort of hypertensive patients:the graz endocrine causes ofhypertension (GECOH) study[J].International Journal of Endocrinology,2012,2012:732636-732644.

[37] EMILY E H,BERDINE R M,PAMELA J L,et al.Bioavailability and efficacy of vitamin D₂ from UV-irradiated yeast in growing,vitamin D-deficient rats[J].Journal of Agricultural and Food Chemistry,2011,59(6):2341-2346.

[38] WEBB A R,ENGELSEN O.Ultraviolet exposure scenarios:risks of erythema from recommend-ations on cutaneous vitamin D synthesis[J].Advances in Experimental Medicine and Biology,2008,624:72-85.

[39] EDWARDS H M,ELLIOT M A,BRITTON W M,et al.Quantitative requirement for cholecalciferol in the absence of ultraviolet light[J].Poultry Science,1994,73:288-294.

[40] LEDWABA M F,ROBERSON K D.Effectiveness of twenty-five-hydroxycholecalciferol in the prevention of tibial dyschondroplasia in ross cockerels depends on dietary calcium level[J].Poultry Science,2003,82:1769-1777.

[41] HOLICK M F,BIANCUZZO R M,CHEN T C,et al.Vitamin D₂ is as effective as vitamin D₃ in maintaining circulating concentrations of 25-hydroxyvitamin D[J].Journal of Clinical Endocrinology & Metabolism,2008,93:677-681.

[42] SAADI H F,DAWODU A,AFANDI B O,et al.Efficacy of daily and monthly high-dose calciferol in vitamin D-deficient nulliparous and lactating women[J].American Journal of Clinical Nutrition,2007,85:1565-1571.

[43] HOLVIK K,MADAR A A,MEYER H E,et al.A randomised comparison of increase in serum 25-hydroxyvitamin D concentration after 4 weeks of daily oral intake of 10 microg cholecalciferol from multivitamin tablets or fish oil capsules in healthy young adults[J].British Journal of Nutrition,2007,98:620-625.

[44] HEANEY R P,DAVIES K M,HOLICK M F,et al.Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol[J].American Journal of Clinical Nutrition,2003,77:204-210.

[45] MAALOUF J,NABULSI M,VIETH R,et al.Shortand long-term safety of weekly high-dose vitamin D₃ supplementation in school children[J].Journal of Clinical Endocrinology & Metabolism,2008,93:2693-2701.

[46] HOLMBERG I,AKSNES L,BERLIN T,et al.Absorption of a pharmac-ological dose of vitamin D₃ from two different lipid vehicles in man: comparison of peanut oil and a medium chain triglyceride[J].Biopharmaceutics Drug Disposition,1990,11:807-815.

[47] FORREST S A,YADA R Y,ROUSSEAU D.Interactions of vitamin D₃ with bovine beta-lactoglobulin A and beta-casein[J].Journal of Agricultural and Food Chemistry,2005,53:8003-8009.

[48] WANG Q,ALLEN J C,SWAISGOOD H E.Binding of vitamin D and cholesterol to beta-lobulinlactog[J].Journal of Dairy Science,1997,80:1054-1059.