综述 Review

脂肪酸转运蛋白家族及其介导的脂肪酸跨膜转运

  • 齐仁立 ,
  • 黄金秀 ,
  • 杨飞云 ,
  • 黄勇
展开
  • 重庆市畜牧科学院,农业部养猪科学重点实验室,养猪科学重庆市市级重点实验室,荣昌 402460

收稿日期: 2012-11-15

  网络出版日期: 2013-04-12

基金资助

国家"973"计划项目(2012CB124702);重庆市百名杰出科技领军人才培养计划项目;重庆市科委基本科研业务费(12617)

Fatty Acid Transport Protein Family and Their Mediation in Transmembrane Transportation of Fatty Acids

  • QI Renli ,
  • HUANG Jinxiu ,
  • YANG Feiyun ,
  • HUANG Yong
Expand
  • Chongqing Key Laboratory of Pig Industry Sciences, Key Laboratory of Pig Industry Sciences, Ministry of Agriculture, Chongqing Academy of Animal Sciences, Rongchang 402460, China

Received date: 2012-11-15

  Online published: 2013-04-12

摘要

脂肪酸是动物必需的能源和结构物质,脂肪酸的吸收、转运和代谢对动物的健康具有重要影响。近年来的研究表明,一些蛋白介导了不同细胞对脂肪酸的吸收和排出。脂肪酸转运蛋白家族(FATPs)是一个膜蛋白家族,拥有6个家族成员,它们能够特异性调控脂肪酸在不同细胞的跨膜转运。本文对FATPs的家族成员、表达特点、功能调控及其参与的脂肪酸转运进行概述。

关键词: 脂肪酸; FATPs; 跨膜转运

本文引用格式

齐仁立 , 黄金秀 , 杨飞云 , 黄勇 . 脂肪酸转运蛋白家族及其介导的脂肪酸跨膜转运[J]. 动物营养学报, 2013 , 25(5) : 905 -911 . DOI: 10.3969/j.issn.1006-267x.2013.05.003

Abstract

Fatty acids are a kind of energy and structural material for animals, therefore, absorption, transportation and metabolism of fatty acids have important influences on the animal's health, growth and production. In recent years, accumulated studies showed that some proteins mediated the process of fatty acid flux in/out many kinds of cells. The fatty acid transport protein family (FATPs) is a transmembrane protein family of six members. All of them could specifically regulate the transmembrane transportation of fatty acids in different cells. This paper reviewed the expression characteristics and functional regulation of FATPs members and the potential model for transmembrane transportation of fatty acids.

参考文献

[1] DUTTA A K R.Cellular uptake of long-chain fatty acids:role of membrane-associated fatty-acid-binding:transport proteins[J].Cellular and Molecular Life Sciences,2000,57:1360-1372.

[2] SELLMAYER A,DANESCH U,WEBER P C.Effects of polyunsaturated fatty acids on growth related early gene expression and cell growth[J].Lipids,1996,31:37-40.

[3] KAMP F,HAMILTON J A,WESTERHOFF H V.Movement of fatty acids,fatty acid analogues,and bile acids across phospholipid bilayers[J].Biochemistry,1993,32:11074-11086.

[4] LOBO S,WICZER B M,SMITH A J,et al.Fatty acid metabolism in adipocytes:functional analysis of fatty acid transport proteins 1 and 4[J].Journal of Lipid Research,2007,48:609-620.

[5] DOEGE H,STAHL A.Protein-mediated fatty acid uptake:novel insights from in vivo models[J].Physiology,2005,21:259-268.

[6] STAHL A.A current review of fatty acid transport proteins (SLC27)[J].Pflügers Archiv,2004,447:722-727.

[7] POHL J,RING A,KORKIMAZ U,et al.FAT/CD 36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts[J].Molecular Biology of the Cell,2005,16:24-31.

[8] NICKERSON J G,ALKHATEEB H,BENTON C R,et al.Greater transport efficiencies of the membrane fatty acid transporters fat/cd36 and fatp4 than fabppm and fatp1,and differential effects on fatty acid esterification and oxidation in rat skeletal muscle[J].Journal of Biology Chemistry,2009,284:16522-16530.

[9] WU Q W,ORTEGON A M,TSANG B,et al.FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity[J].Molecular and Cellular Biology,2006,26:3455-3467.

[10] SCHAFFER J E,LODISH H F.Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein[J].Cell,1994,79:427-436.

[11] HIRSCH D,STAHL A,LODISH H F.A family of fatty acid transporters conserved from mycobacterium to man[J].Proceedings of the National Academy of Sciences,1998,95:8625-8629.

[12] BERGER J,TRUPPE C,NEUMANN H,et al.A novel relative of the very long-chain acyl-CoA synthetase and fatty acid transporter protein genes with a distinct expression pattern[J].Biochemistry Biophysical Research Communication,1998,247:255-260.

[13] BERGER J,TRUPPE C,NEUMANN H,et al.cDNA cloning and mRNA distribution of a mouse very long-chain acyl-CoA synthetase[J].FEBS Letter,1998,425:305-309.

[14] SCHAAP F G,HAMERS L,GER J V V,et al.Molecular cloning of fatty acid-transport protein cDNA from rat[J].Biochemistry and Biophysical Acta,1997,1354:29-34.

[15] FITSCHER B A,RIEDEL D D,YOUNG K C,et al.Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4)[J].Biochemistry and Biophysical Acta,1998,1443:381-385.

[16] WATKINS P A,PEVSENER J,STEINBERG S J.Human very long-chain acyl-CoA synthetase and two human homologs:initial characterization and relationship to fatty acid transport protein[J].Prostaglandins Leukot Essent Fatty Acids,1999,60:323-328.

[17] HIRSCH D,STAHL A,LODISH H F.A family of fatty acid transporters conserved from mycobacterium to man[J].Proceedings of the National Academy of Sciences,1998,95:8625-8629.

[18] FROHNERT B I,HUI T Y,BERNLOHR D A.Identification of a functional peroxisome proliferator-responsive element in the murine fatty acid transport protein gene[J].Journal of Biology Chemistry,1999,274:3970-3977.

[19] LENA S L,JANA M,WALEE C,et al.Adipocyte-specific inactivation of the acyl-CoA-synthetase fatty acid transport protein 4 (Fatp4) in mice causes adipose hypertrophy and alterations in metabolism of complex lipids under high-fat diet[J].Journal of Biology Chemistry,2011,286(41):35578-35587.  

[20] GIMENO R E,HIRSCH D J,PUNREDDY S,et al.Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality[J].Journal of Biology Chemistry,2003,278:49512-49516.

[21] GIMENO R E,ORTEGON A M,PATEL S,et al.Characterization of a heart-specific fatty acid transport protein[J].Journal of Biology Chemistry,2003,278:16039-16044.

[22] ABUMRAD N,HARMON C,LBRAHIMI A.Membrane transport of long-chain fatty acids:evidence for a facilitated process[J].Journal of Lipid Research,1998,39:2309-2318.

[23] UCHIYAMA A,AOYAMA T,KAMIJO K,et al.Molecular cloning of cDNA encoding rat very long-chain acyl-CoA synthetase[J].Journal of Biology Chemistry,1996,271:30360-30365.

[24] MARTIN G,SCHOONJANS K,LEFEBVRE A M,et al.Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPAR alpha and PPAR gamma activators[J].Journal of Biology Chemistry,1997,272:28210-28217.

[25] MARTIN G,POIRIER H,HENNUYER N,et al.Induction of the fatty acid transport protein 1 and acyl-CoA synthase genes by dimer-selective rexinoids suggests that the peroxisome proliferator-activated receptor-retinoid X receptor heterodimer is their molecular target[J].Journal of Biology Chemistry,2000,275:12612-12618.

[26] MOTOJIMA K,PASSILLY P,PETERS J M,et al.Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer specific manner[J].Journal of Biology Chemistry,1998,273:16710-16714.

[27] FROHNERT B I,HUI T Y,BERNLOHR D A.Identification of a functional peroxisome proliferator-responsive element in the murine fatty acid transport protein gene[J].Journal of Biology Chemistry,1999,274:3970-3977.

[28] BERK P D,ZHOU S L,KIANG C L,et al.Uptake of long chain free fatty acids is selectively up-regulated in adipocytes of Zucker rats with genetic obesity and non-insulin dependent diabetes mellitus[J].Journal of Biology Chemistry,1997,272:8830-8835.

[29] MAN M Z,HUI T Y,SCHAFFER J E,et al.Regulation of the murine adipocyte fatty acid transporter gene by insulin[J].Journal of Molecular Endocrinology,1996,10:1021-1028.

[30] HARASIM E,KALINOWSKA A,CHABOWSKI A,et al.The role of fatty-acid transport proteins (FAT/CD36,FABPpm,FATP) in lipid metabolism in skeletal muscles[J].Postpy Higieny I Medycyny Dos'wiadczalnej,2008,25;62:433-441.

[31] JEPPESEN J,JORDY A B,SJBERG K A,et al.Enhanced fatty acid oxidation and FATP4 protein expression after endurance exercise training in human skeletal muscle[J].PLoS One,2012,7(1):29391.doi: 10.1371/journal.pone.0029391.

[32] GLATZ J F,LUIKEN J J,BONEN A.Involvement of membrane-associated proteins in the acute regulation of cellular fatty acid uptake[J].Journal of Molecular Neuroscience,2001,16:123-132.

[33] STUHLSATZ K S M,BENNETT N E,SCHAFFER J E.Molecular aspects of fatty acid transport:mutations in the IYTSGTTGXPK motif impair fatty acid transport protein function[J].Prostaglandins Leukot Essent Fatty Acids,1999,60:285-289.

[34] DIRUSSO C C,DARWIS D,OBERMEYER T,et al.Functional domains of the fatty acid transport proteins:studies using protein chimeras[J].Biochimica et Biophysica Acta,2008,1781:135-143.

[35] STUHLSATZ K S M,BENNETT N E,SCHAFFER J E.Substitution of alanine for serine 250 in the murine fatty acid transport protein inhibits long chain fatty acid transport[J].Journal of Biology Chemistry,1998,273:28642-28650.

[36] COE N R,SMITH A J,FROHNERT B I,et al.The fatty acid transport protein (FATP1) is a very long chain acyl-CoA synthetase[J].Journal of Biology Chemistry,1999,274:36300-36304.

[37] JAN F G,JOOST J L,AREND B.Membrane fatty acid transporters as regulators of lipid metabolism:implications for metabolic disease[J].Physiological Reviews,2010,90:367-417.

[38] MOSER A B,KREITER N,BEZMAN L,et al.Plasma very long chain fatty acids in 3,000 peroxisome disease patients and 29,000 controls[J].Annals of neurology,1999,45:100-110.

[39] UCHIDA Y,KONDO N,ORII T,et al.Purification and properties of rat liver peroxisomal very-long-chain acyl-CoA synthetase[J].Journal of Biochemistry,1996,119:565-570.

[40] BONEN A,CHABOWSKI A,LUIKEN J J,et al.Is membrane transport of FFA mediated by lipid,protein,or both?Mechanisms and regulation of protein-mediated cellular fatty acid uptake:molecular,biochemical,and physiological evidence[J].Physiology,2007,22:15-29.

[41] HOLLOWAY G P,LALLY J,NICKERSON J G,et al.Fatty acid binding protein facilitates sar-colemmal fatty acid transport but not mitochondrial oxidation in rat and human skeletal muscle[J].Journal of Physiology,2007,582:393-405.
文章导航

/