动物营养学报 >

2013 , Vol. 25 >Issue 5: 943 - 950

DOI: https://doi.org/10.3969/j.issn.1006-267x.2013.05.008

综述 Review

反刍动物营养代谢调控的数学模型化

  • 易渺 ,
  • 杨琴 ,
  • 熊本海
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  • 中国农业科学院北京畜牧兽医研究所,动物营养学国家重点实验室,北京 100193

收稿日期: 2012-11-19

  网络出版日期: 2013-04-12

基金资助

973计划课题(2011CB100805);863计划课题(2012AA101905)

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Mathematical Modeling for Regulations of Nutritional Metabolism in Ruminants

  • YI Miao ,
  • YANG Qin ,
  • XIONG Benhai
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  • State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Received date: 2012-11-19

  Online published: 2013-04-12

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摘要

模型是现实情景的模拟再现。在营养、代谢和生物医学等领域,很早就开始利用数学模型来辅助进行了相关研究。动物数学模型化技术作为一种行之有效的研究手段,不仅能大量利用动物营养学过去的科研成果、整合现有的理论知识,更能指明动物营养学未来研究的薄弱领域或方向。本文立足数学模型的内涵,介绍了动物数学模型的分类和动物系统的层次结构,通过阐释动物营养代谢的自我调控理论,总结了近30年来主要的动物营养代谢调控模型,尤其与激素有关的代谢调控模型的新进展,分析了营养模型化研究所面临的挑战和发展趋势。数学模型在动物营养代谢调控中的应用,对于预测动物营养需要、绘制动物体内营养物质代谢调控通路等多个方面都具有重要意义。

关键词： 数学模型; 模型化; 反刍动物; 营养; 代谢调控

本文引用格式

易渺 , 杨琴 , 熊本海 . 反刍动物营养代谢调控的数学模型化[J]. 动物营养学报, 2013 , 25(5) : 943 -950 . DOI: 10.3969/j.issn.1006-267x.2013.05.008

Abstract

Models are the representation of reality. Mathematical models have been used in the research fields of nutrition, metabolism and biomedicine for a long time. Mathematical modelings in animal as an effective research tool have been used not only to sum up past achievement and integrate present theory, but also to show where gaps in knowledge exist and what further research should focus on. Based on the connotation of mathematical models, this review introduces the categories of mathematical models in animal and the hierarchy of animal system, summarizes major relevant models in metabolic regulation over the past three decades according to explanation the theory of self-regulation in animal nutrient metabolism, especially in the advances on the regulation models related in hormones. The challenges and the development trend of modeling research in animal nutrition are also analyzed. The application of mathematical models in metabolic regulation of animal nutrition bears substantial significance for the dynamical prediction of animal nutrient requirements and drawing metabolic pathways of nutrients in animals.

Key words： mathematical model; modeling; ruminant; nutrition; metabolic regulation

参考文献

[1] BALDWIN R L.Modeling ruminant digestion and metabolism[M].London:Chapman & Hall,1995:9-26.

[2] TEDESCHI L O,FOX D G,SAINZ R D,et al.Mathematical models in ruminant nutrition[J].Scientia Agricola,2005,62:76-91.

[3] MCNAMARA J P.Research,improvement and application of mechanistic,biochemical,dynamic models of metabolism in lactating dairy cattle[J].Animal Feed Science and Technology,2004,112(1):155-176.  

[4] THORNLEY J H M,FRANCE J.Mathematical models in agriculture:quantitative methods for the plant,animal and ecological sciences[M].Wallingford:CABI,2007:7-10.

[5] ØRSKOV E R,MCDONALD I.The estimation of protein degradability in the rumen from incubation measurements weighted according to rate of passage[J].The Journal of Agriculture Science,1979,92(2):499-503.  

[6] 熊本海,罗清尧,马毅,等.中国荷斯坦奶牛第三泌乳期泌乳曲线模型的研究[J].中国农业科学,2011,44(2):402-408.

[7] FRANCE J,KEBREAB E.Mathematical modelling in animal nutrition[M].Wallingford:CABI,2008:2-3.

[8] DUMAS A,DIJKSTRA J,FRANCE J.Mathematical modelling in animal nutrition:a centenary review[J].The Journal of Agricultural Science,2008,146(2):123-142.

[9] 倪银华,吴涛,金黎,等.哺乳动物营养代谢的时间生物学研究进展[J].中国细胞生物学学报,2011,33(2):190-196.

[10] 卢德勋.系统动物营养学导论[M].北京:中国农业出版社,2004:73.

[11] FRIGGENS N C,BRUN-LAFLEUR L,FAVERDIN P,et al.Advances in predicting nutrient partitioning in the dairy cow:recognizing the central role of genotype and its expression through time[J].Animal,2011.doi:10.1017/S1751731111001820.

[12] 卢德勋.动物机体自我营养调控功能及其实践意义[J].内蒙古畜牧科学,1995(1):1-10.

[13] INGVARTSEN K L.Feeding- and management-related diseases in the transition cow:physiological adaptations around calving and strategies to reduce feeding-related diseases[J].Animal Feed Science and Technology,2006,126(3):175-213.  

[14] BAUMAN D E,CURRIE W B.Partitioning of nutrients during pregnancy and lactation:a review of mechanisms involving homeostasis and homeorhesis[J].Journal of Dairy Science,1980,63(9):1514-1529.  

[15] FRIGGENS N C,NEWBOLD J R.Towards a biological basis for predicting nutrient partitioning:the dairy cow as an example[J].Animal,2007,1(1):87-97.  

[16] SAUVANT D.Modelling homeostatic and homeorhetic regulations in lactating animals[J].Livestock Production Science,1994,39(1):105-113.  

[17] BERGMAN E N.Energy contributions of volatile fatty acids from the gastrointestinal tract in various species[J].Physiological Reviews,1990,70(2):567-590.

[18] MURPHY M R,BALDWIN R L,KOONG L J.Estimation of stoichiometric parameters for rumen fermentation of roughage and concentrate diets[J].Journal of Animal Science,1982,55(2):411-421.

[19] BALDWIN R L,THORNLEY J H,BEEVER D E.Metabolism of the lactating cow:Ⅱ.Digestive elements of a mechanistic model[J].Journal of Dairy Research,1987,54(1):107-131.  

[20] DIJKSTRA J,NEAL H D,BEEVER D E,et al.Simulation of nutrient digestion,absorption and outflow in the rumen:model description[J].The Journal of Nutrition,1992,122(11):2239-2256.

[21] BANNINK A,KOGUT J,DIJKSTRA J,et al.Estimation of the stoichiometry of volatile fatty acid production in the rumen of lactating cows[J].Journal of Theoretical Biology,2006,238(1):36-51.  

[22] BANNINK A,FRANCE J,LOPEZ S,et al.Modelling the implications of feeding strategy on rumen fermentation and functioning of the rumen wall[J].Animal Feed Science and Technology,2008,143(1):3-26.  

[23] HANIGAN M D,CROMPTON L A,REYNOLDS C K,et al.An integrative model of amino acid metabolism in the liver of the lactating dairy cow[J].Journal of Theoretical Biology,2004,228(2):271-289.  

[24] FREETLY H C,KNAPP J R,CALVERT C C,et al.Development of a mechanistic model of liver metabolism in the lactating cow[J].Agricultural Systems,1993,41(2):157-195.  

[25] FRANCE J,HANIGAN M D,REYNOLDS C K,et al.An isotope dilution model for partitioning leucine uptake by the liver of the lactating dairy cow[J].Journal of Theoretical Biology,1999,198(1):121-133.  

[26] NEAL H D S C,THORNLEY J H M.The lactation curve in cattle:a mathematical model of the mammary gland[J].The Journal of Agricultural Science,1983,101(2):389-400.  

[27] DIJKSTRA J,FRANCE J,DHANOA M S,et al.A model to describe growth patterns of the mammary gland during pregnancy and lactation[J].Journal of Dairy Science,1997,80(10):2340-2354.  

[28] VETHARANIAM I,DAVIS S R,SOBOLEVA T K,et al.Modeling the interaction of milking frequency and nutrition on mammary gland growth and lactation[J].Journal of Dairy Science,2003,86(6):1987-1996.  

[29] VETHARANIAM I,DAVIS S R,UPSDELL M,et al.Modeling the effect of energy status on mammary gland growth and lactation[J].Journal of Dairy Science,2003,86(10):3148-3156.  

[30] POLLOTT G E.A biological approach to lactation curve analysis for milk yield[J].Journal of Dairy Science,2000,83(11):2448-2458.  

[31] POLLOTT G E.Deconstructing milk yield and composition during lactation using biologically based lactation models[J].Journal of Dairy Science,2004,87(8):2375-2387.  

[32] BALDWIN R L,FRANCE J,BEEVER D E,et al.Metabolism of the lactating cow:Ⅲ.Properties of mechanistic models suitable for evaluation of energetic relationships and factors involved in the partition of nutrients[J].Journal of Dairy Research,1987,54(1):133-145.  

[33] BALDWIN R L,FRANCE J,GILL M.Metabolism of the lactating cow:Ⅰ.Animal elements of a mechanistic model[J].Journal of Dairy Research,1987,54(1):77-105.  

[34] MARTIN O,SAUVANT D.A teleonomic model describing performance(body,milk and intake)during growth and over repeated reproductive cycles throughout the lifespan of dairy cattle:1.Trajectories of life function priorities and genetic scaling[J].Animal,2010,4(12):2030-2047.  

[35] DANFAER A.A dynamic model of nutrient digestion and metabolism in lactating dairy cows[D].Ph.D.thesis.Foulum:National Institute of Animal Sciences,1990.

[36] HERBEIN J H,AIELLO R J,ECKLER L I,et al.Glucagon,insulin,growth hormone,and glucose concentrations in blood plasma of lactating dairy cows[J].Journal of Dairy Science,1985,68(2):320-325.  

[37] MARTIN O,SAUVANT D.Dynamic model of the lactating dairy cow metabolism[J].Animal,2007,1(8):1143-1166.

[38] ELLIS J L,QIAO F,CANT J P.Evaluation of net energy expenditures of dairy cows according to body weight changes over a full lactation[J].Journal of Dairy Science,2006,89(5):1546-1557.  

[39] ALLEN M S.Mind over models[C]//EASTRIDGE M L.Proceedings of the 20th annual tri-state dairy nutrition conference.Ohio:Ohio State University,2011:29-44.

[40] LUCY M C,VERKERK G A,WHYTE B E,et al.Somatotropic axis components and nutrient partitioning in genetically diverse dairy cows managed under different feed allowances in a pasture system[J].Journal of Dairy Science,2009,92(2):526-539.  

[41] SUMNER-THOMSON J M,VIERCK J L,MCNAMARA J P.Differential expression of genes in adipose tissue of first-lactation dairy cattle[J].Journal of Dairy Science,2011,94(1):361-369.  

[42] ALLAN M F,EISEN E J,POMP D.Genomic mapping of direct and correlated responses to long-term selection for rapid growth rate in mice[J].Genetics,2005,170(4):1863-1877.  

[43] GO V L,NGUYEN C T,HARRIS D M,et al.Nutrient-gene interaction:metabolic genotype-phenotype relationship[J].The Journal of Nutrition,2005,135(12):3016S-3020S.

[44] LAVELLE C,BERRY H,BESLON G,et al.From molecules to organisms:towards multiscale integrated models of biological systems[J].Theoretical Biology Insights,2008(1):13-22.

[45] GILL M,BEEVER D E,FRANCE J.Biochemical bases needed for the mathematical representation of whole animal metabolism[J].Nutrition Research Reviews,1989,2(1):181-200.  
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