综述 Review

小G蛋白对mTOR信号通路的调控

  • 柯丹霞 ,
  • 印遇龙
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  • 中国科学院亚热带农业生态研究所,亚热带农业生态过程重点实验室,湖南省畜禽健康养殖工程技术中心, 农业部中南动物营养与饲料科学观测实验站,长沙 410125

收稿日期: 2013-02-18

  网络出版日期: 2013-07-15

基金资助

中国科学院亚热带农业生态研究所领域前沿项目(Y151012100);国家973项目(2013CB127301)

Regulation of mTOR Signaling Pathway by Small G Proteins

  • KE Danxia ,
  • YIN Yulong
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  • Observation and Experiment Station of Animal Nutrition and Feed Science in South Central, Ministry of Agriculture, Key Laboratory of Agro-Ecological Processes in Subtropical Region, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China

Received date: 2013-02-18

  Online published: 2013-07-15

摘要

哺乳动物雷帕霉素靶蛋白(mTOR)是一种重要的信号调控分子,通过磷酸化作用调控细胞内mRNA的翻译,参与膜蛋白转运、蛋白质降解、蛋白激酶c信号转导和核糖体合成等.不同家族的小G蛋白,如Rheb、Rag、RalA、Rac1和Rab5,在调控mTOR信号通路中发挥着重要作用.Rheb结合并直接激活mTOR,Rag和Rac1介导mTOR的定位,RalA通过磷脂酸的产生间接激活mTOR,Rab5调控mTORC1的活化和定位.本文将围绕近年来发现的多种小G蛋白家族成员参与调控mTOR信号通路的研究进展进行综述.

关键词: Rheb; Rag; RalA; Rac1; Rab5; mTOR信号通路

本文引用格式

柯丹霞 , 印遇龙 . 小G蛋白对mTOR信号通路的调控[J]. 动物营养学报, 2013 , 25(8) : 1663 -1670 . DOI: 10.3969/j.issn.1006-267x.2013.08.001

Abstract

mTOR is an important signal regulatory moleculor that regulates mRNA translation in cells by phosphorylation, and participates in the transport of membrane proteins, protein degradation, protein kinase C signal transduction and ribosome biogenesis, et al. A diverse group of small G proteins including Rheb, Rag, RalA, Rac1 and Rab5 play a variety of roles in the regulation of mTOR signaling pathway. For example, while Rheb binds to and activates mTOR directly, Rag and Rac1 mediate its localization, RalA activates it indirectly by the production of phosphatidic acid, and Rab5 regulates its activition and localization. Here, we review recent findings on the regulation of the mTOR signaling pathway by a variety of small G protein family members.

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