综述 Review

肠道与微生物相互作用体外研究模型进展与应用

  • 刘刚 ,
  • 任文凯 ,
  • 熊霞 ,
  • 李铁军 ,
  • 钟瑾 ,
  • 印遇龙
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  • 1. 中国科学院亚热带农业生态研究所,中国科学院亚热带农业生态过程重点实验室,湖南省畜禽健康养殖工程技术中心, 农业部中南动物营养与饲料科学观测实验站,长沙 410125;
    2. 中国科学院微生物研究所, 微生物资源前期开发国家重点实验室,北京 100101

收稿日期: 2013-02-26

  网络出版日期: 2013-07-15

基金资助

湖南省科技计划项目(2012WK4021);中国科学院知识创新工程重要方向项目(KSCX2-EW-G-16);微生物资源前期开发国家重点实验室开放课题(SKLMR-20110607)

Advances and Applications of in Vitro Models for Host-Microbe Interactions Research

  • LIU Gang ,
  • REN Wenkai ,
  • XIONG Xia ,
  • LI Tiejun ,
  • ZHONG Jin ,
  • YIN Yulong
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  • 1. Institute of Subtropical Agriculture, Chinese Academy of Sciences, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Hunan Provincial Engineering Research Center of Healthy Livestock and Poultry,Key Laboratory of Agro-Ecological Processes in Subtropical Region, Changsha 410125, China;
    2. Institute of Microbiology, Chinese Academy of Sciences, State Key Laboratory of Microbial Resources, Beijing 100101, China

Received date: 2013-02-26

  Online published: 2013-07-15

摘要

肠道微生物对机体的营养代谢、能量代谢和免疫功能等具有十分重要的作用,而微生物黏附、定植以及同宿主肠上皮的相互作用在这些过程中至关重要,因而深入理解微生物和肠道之间的相互作用是阐明微生物如何参与机体营养、代谢和免疫过程的关键.本文综述了研究微生物与肠道相互作用的主要体外模型,以及应用这些模型取得的研究进展.

本文引用格式

刘刚 , 任文凯 , 熊霞 , 李铁军 , 钟瑾 , 印遇龙 . 肠道与微生物相互作用体外研究模型进展与应用[J]. 动物营养学报, 2013 , 25(8) : 1677 -1682 . DOI: 10.3969/j.issn.1006-267x.2013.08.003

Abstract

Gut microbes play important roles in the nutrient metabolism, energy metabolism and immune function. Microbial adhesion, colonization, and interactions with host intestinal epithelial cells in these processes are essential, therefore in-depth understanding of crosstalk between the microbe and the host is a key to clarify how microbes involve in nutritional, metabolic and immune processes. In this paper, we reviewed several intestinal microbe interaction research models, as well as the advances and applications in these models.

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