[1] FURUSE M,HIRASE T,ITOH M,et al.Occludin:a novel integral membrane protein localizing at tight junctions[J].The Journal of Cell Biology,1993,123(6):1777-1788.

[2] FURUSE M,ITOH M,HIRASE T,et al.Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions[J].The Journal of Cell Biology,1994,127(6):1617-1626.

[3] GONZALEZ-MARISCAL L,BETANZOS A,NAVA P,et al.Tight junction proteins[J].Progress in Biophysics & Molecular Biology,2003,81(1):1-44.

[4] BALDA M S,ALDA J A,WHITNEY C,et al.Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein[J].The Journal of Cell Biology,1996,134(4):1031-1049.

[5] CHEN Y H,MERZDORF C,PAUL D L,et al.COOH terminus of occludin is required for tight junction barrier function in early
Xenopus embryos[J].The Journal of Cell Biology,1997,138(4):891-899.

[6] MATTER K,BALDA M S.Biogenesis of tight junctions:the C-terminal domain of occludin mediates basolateral targeting[J].Journal of Cell Science,1998,111(Pt 4):511-519.
[7] BAMFORTH S D,KNIESEL U,WOLBURG H,et al.A dominant mutant of occludin disrupts tight junction structure and function[J].Journal of Cell Science,1999,112(Pt 12):1879-1888.
[8] WONG V,GUMBINER B M.A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrier[J].Journal of Cell Biology,1997,136(2):399-409.

[9] LACAZ-VIERA F,JAEGER M M M,FARSHORI P,et al.Small synthetic peptides homologous to segments of the first external loop of occludin impair tight junction resealing[J].Journal of Membrane Biology,1999,168(3):289-297.

[10] MEDINA R,RAHNER C,MITIC L L,et al.Occludin localization at the tight junction requires the second extracellular loop[J].Journal of Membrane Biology,2000,178(3):235-247.

[11] GONZALEZ-MARISCAL L,NAMORADO M C,MARTIN D,et al.Tight junction proteins ZO-1,ZO-2,and occludin along isolated renal tubules[J].Kidney International,2000,57(6):2386-2402.

[12] FURUSE M,SASAKI H,FUJIMOTO K,et al.A single gene product,claudin-1 or-2,reconstitutes tight junction strands and recruits occludin in fibroblasts[J].The Journal of Cell Biology,1998,143(2):391-401.

[13] FUJIMOTO K.Freeze-fracture replica electron microscopy combined with SDS digestion for cytochemical labeling of integral membrane proteins.Application to the immunogold labeling of intercellular junctional complexes[J].Journal of Cell Science,1995,108(Pt 11):3443-3449.
[14] ITOH M,MORITA K,TSUKITA S.Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin[J].Journal of Biological Chemistry,1999,274(9):5981-5986.

[15] WITTCHEN E S,HASKINS J,STEVENSON B R.Protein interactions at the tight junction.Actin has multiple binding partners,and ZO-1 forms independent complexes with ZO-2 and ZO-3[J].Journal of Biological Chemistry,1999,274(49):35179-35185.

[16] WITTCHEN E S,HASKINS J,STEVENSON B R.Protein interactions at the tight junction.Actin has multiple binding partners,and ZO-1 forms independent complexes with ZO-2 and ZO-3[J].Journal of Biological Chemistry,1999,274(49):35179-35185.

[17] SCHNEEBERGER E E,LYNCH R D.The tight junction:a multifunctional complex[J].American Journal of Physiology:Cell Physiology,2004,286(6):C1213-C1228.
[18] SHIN K,FOGG V C,MARGOLIS B.Tight junctions and cell polarity[J].Annual Review of Cell and Developmental Biology,2006,22(1):207-235.

[19] MCCARTHY K M,SKARE I B,STANKEWICH M C,et al.Occludin is a functional component of the tight junction[J].Journal of Cell Science,1996,109(Pt 9):2287-2298.
[20] VAN ITALLI C M,ANDERSON J M.Occludin confers adhesiveness when expressed in fibroblasts[J].Journal of Cell Science,1997,110:1113-1121.
[21] HERMISTON M L,GORDON J I.Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin[J].Science,1995,270:1203-1207.
[22] KUCHARZIK T,WALSH S V,CHEN J,et al.Neutrophil transmigration in inflammatory bowel disease is associated with differential expression of epithelial intercellular junction proteins[J].American Journal of Pathology,2001,159(6):2001-2009.

[23] MCDERMOTT J R,BARTRAM R E,KNIGHT P A,et al.Mast cells disrupt epithelial barrier function during enteric nematode infection[J].Proceedings of the National Academy of Sciences of the United States of America,2003,100(13):7761-7766.

[24] 张中伟,秦环龙.乳酸菌对感染肠上皮细胞通透性及紧密连接蛋白表达的影响[J].肠外与肠内营养,2007,14(4):193-200.
[25] BESSELINK M G,VAN SANTYOORT H C,RENOOIJ W,et al.Intestinal barrier dysfunction in a randomized trial of a specific probiotic composition in acute pancreatitis[J].Annals of Surgery,2009,250(5):712-719.

[26] SHIFFLETT D E,CLAYBURGH D R,KOUTSOURIS A,et al.Enteropathogenic
E.coli disrupts tight junction barrier function and structure
in vivo[J].Laboratory Investigation,2005,85(10):1308-1324.

[27] ANDREEVA A Y,KRAUSE E,MULLER E C,et al.Protein kinase C regulates the phosphorylation and cellular localization of occludin[J].Journal of Biological Chemistry,2001,276(42):38480-38486.

[28] SAKAKIBARA A,FURUSE M,SAITOU M,et al.Possible involvement of phosphorylation of occludin in tight junction formation[J].The Journal of Cell Biology,1997,137(6):1393-1401.

[29] TSUKAMOTO T,NIGAM S K.Role of tyrosine phosphorylation in the reassembly of occludin and other tight junction proteins[J].American Journal of Physiology,1999,276(5 Pt 2):F737-F750.
[30] DEMAIO L,CHANG Y S,GARDNER T W,et al.Shear stress regulates occludin content and phosphorylation[J].American Journal of Physiology:Heart and Circulatory Physiology,2001,281(1):H105-H113.
[31] WONG V.Phosphorylation of occludin correlates with occludin localization and function at the tight junction[J].American Journal of Physiology,1997,73(6 Pt 1):C1859-C1867.
[32] KALE G,NAREN A P,SHETH P,et al.Tyrosine phosphorylation of occludin attenuates its interactions with ZO-1,ZO-2,and ZO-3[J].Biochemical and Biophysical Research Communications,2003,302(2):324-329.

[33] MA T Y,TRAN D,HOA N,et al.Mechanism of extracellular calcium regulation of intestinal epithelial tight junction permeability:role of cytoskeletal involvement[J].Microscopy Research and Technique,2000,51(2):156-168.

[34] SONG J C,HANSON C M,TSAI V,et al.Regulation of epithelial transport and barrier function by distinct protein kinase C isoforms[J].American Journal of Physiology:Cell Physiology,2001,281(2):C649-C661.
[35] PLOTNIKOV A,ZEHORAI E,PROCACCIA S,et al.The MAPK cascades:signaling components,nuclear roles and mechanisms of nuclear translocation[J].Biochimica Biophysica Acta,2011,1813(9):1619-1633.

[36] FUJIMOTO K.Freeze-fracture replica electron microscopy combined with SDS digestion for cytochemical labeling of integral membrane proteins.application to the immunogold labeling of intercellular junctional complexes[J].Journal of Cell Science,1995,108(Pt 11):3443-3449.
[37] YAMAGUCH Y,DALLE-MOLLE E,HARDISON W G.Vasopressin and A23187 stimulate phosphorylation of myosin light chain-1 in isolated rat hepatocytes[J].American Journal of Physiology,1991,261(2):G312-G319.
[38] MATSUDA M,KUBO A,FURUSE M,et al.A peculiar internalization of claudins,tight junction-specific adhesion molecules,during the intercellular movement of epithelial cells[J].Journal of Cell Science,2004,117:1247-1257.
[39] 秦环龙,高志光.肠上皮细胞紧密连接在肠屏障中的作用研究进展[J].世界华人消化杂志,2005,13(4):443-447.
[40] NUSRAT A,GIRY M,TUNER J R,et al.Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia[J].Proceedings of the National Academy of Sciences of the United States of America,1995,92(23):10629-10633.

[41] BRUEWER M,HOPKINS A M,HOBERT M E,et al.Rho A.Rac1,and Cdc42 exert distinct effects on epithelial barrier via selective structural and biochemical modulation of junctional proteins and F-actin[J].American Journal of Physiology:Cell Physiology,2004,287(2):C327-C335.
[42] WALSH S V,HPOKINS A M,CHEN J,et al.Rho kinase regulates tight junction function and is necessary for tight junction assembly in polarized int