占今舜 , 詹康 , 赵国琦 . 二十二碳六烯酸的提取技术及其在动物生产中的应用[J]. 动物营养学报, 2013 , 25(12) : 2790 -2797 . DOI: 10.3969/j.issn.1006-267x.2013.12.002

[1] DYERBERG J,BANG H O,STOFFERSOM E,et al.Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis?[J].Lancet,1978,2(8081):117-119.

[2] SCHUCHARDT J P,HAHN A.Bioavailability of long-chain omega-3 fatty acids[J].Prostaglandins,Leukotrienes and Essential Fatty Acids,2013,89(1):1-8.  

[3] STROBEL C,JAHREIS G,KUHNT K.Survey of n-3 and n-6 polyunsaturated fatty acids in fish and fish products[J].Lipids in Health and Disease,2012,11(1):144.

[4] DULVY N K,SADOVY Y,REYNOLDS J D.Extinction vulnerability in marine populations[J].Fish and Fisheries,2003,4(1):25-64.  

[5] CALDER P C.Mechanisms of action of (n-3) fatty acids[J].The Journal of Nutrition,2012,142(3):592-599.  

[6] WORM B,BARBIER E B,BEAUMONT N,et al.Impacts of biodiversity loss on ocean ecosystem services[J].Science,2006,314:787-790.

[7] MAHAFFEY K R,CLICKNER R P,JEFFRISE R A.Methylmercury and omega-3 fatty acids:co-occurrence of dietary sources with emphasis on fish and shellfish[J].Environmental Research,2008,107(1):20-29.  

[8] LENIHAN-GEELS G,BISHOP K,FERGUSON L.Alternative sources of omega-3 fats:can we find a sustainable substitute for fish?[J].Nutrients,2013,5(4):1301-1315.  

[9] MARTIN E S,LOLKE S,JACK T P.High-cell-density fed-batch cultivation of the docosahexaenoic acid producing marine alga Crypthecodinium cohnii[J].Biotechnology and Bioengineering,2003,81(6):666-672.  

[10] BURJA A M,RADIANINGTYAS H,WINDUST A,et al.Isolation and characterization of polyunsaturated fatty acid producing Thraustochytrium species:screening of strains and optimization of omega-3 production[J].Applied Microbiology and Biotechnology,2006,72(6):1161-1169.  

[11] ZHU L Y,ZHANG X C,JI L,et al.Changes of lipid content and fatty acid composition of Schizochytrium limacinum in response to different temperatures and salinities[J].Process Biochemistry,2007,42(2):210-214.  

[12] SIJTSMA L,DE SWAAF M E.Biotechnological production and applications of the ω-3 polyunsaturated fatty acid docosahexaenoic acid[J].Applied Microbiology and Biotechnology,2004,64(2):146-153.  

[13] QU L,REN L J,SUN G N,et al.Batch,fed-batch and repeated fed-batch fermentation processes of the marine thraustochytrid Schizochytrium sp.for producing docosahexaenoic acid[J].Bioprocess and Biosystems Engineering,2013,doi:10.1007/s00449-013-0966-7.

[14] SCHUHMANN H,LIM D K Y,SCHENK P M.Perspectives on metabolic engineering for increased lipid contents in microalgae[J].Biofuels,2012,3(1):71-86.  

[15] SUBHADRA B G.Sustainability of algal biofuel production using integrated renewable energy park (IREP) and algal biorefinery approach[J].Energy Policy,2010,38(10):5892-5901.  

[16] BOELEN P,VAN DIJK R,SINNINGHE D J S,et al.On the potential application of polar and temperate marine microalgae for EPA and DHA production[J].AMB Express,2013,3(1):26.

[17] STILLWELL W,WASSALL S R.Docosahexaenoic acid:membrane properties of a unique fatty acid[J].Chemistry and Physics of Lipids,2003,126(1):1-27.  

[18] MA D W,SEO J,SWITZER K C,et al.n-3 PUFA and membrane microdomains:a new frontier in bioactive lipid research[J].The Journal of Nutritional Biochemistry,2004,15(11):700-706.  

[19] LI Q R,WANG M,TAN L,et al.Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts[J].The Journal of Lipid Research,2005,46(9):1904-1913.  

[20] LEAF A,KANG J X,XIAO Y F,et al.Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils[J].Circulation,2006,107(21):2646-2652.

[21] CORRALES G P,RIVERO N L,CULEBRAS-FERNÁNDEZ J M.Role of omega-3 fatty acids in cardiovascular disease prevention[J].Nutrición Hospitalaria,2013,28(1):1-5.  

[22] PARK Y,HARRIS W S.Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance[J].The Journal of Lipid Research,2003,44(3):455-463.  

[23] SINGHAL A,JULIE L,STORRY C,et al.Docosahexaenoic acid supplementation,vascular function and risk factors for cardiovascular disease:a randomized controlled trial in Young adults[J].Journal of the American Heart Association,2013,2(4):e000283.

[24] PIRILLO A,CATAPANO A L.Omega-3 polyunsaturated fatty acids in the treatment of hypertriglyceridaemia[J].International Journal of Cardiology,2013,doi:10.1016/j.ijcard.2013.06.040.

[25] JUNG S B,KWON S K,KWON M,et al.Docosahexaenoic acid improves vascular function via up-regulation of SIRT1 expression in endothelial cells[J].Biochemical and Biophysical Research Communications,2013,437(1):114-119.  

[26] LORENTE C S,COSTA A G,NAVAS C S,et al.Role of omega-3 fatty acids in obesity,metabolic syndrome,and cardiovascular diseases:a review of the evidence[J].Journal of Physiology and Biochemistry,2013,69(3):633-651.  

[27] CALDER P C.Polyunsaturated fatty acids,inflammation,and immunity[J].Lipids,2001,36(9):1007-1024.  

[28] CALDER P C.n-3 polyunsaturated fatty acids,inflammation,and inflammatory diseases[J].American Journal of Clinical Nutrition,2006,83(Suppl.6):1505S-1519S.

[29] KYRATKO C N,BARRETT E C,NELSON E B,et al.The relationship of docosahexaenoic acid (DHA) with learning and behavior in healthy children:a review[J].Nutrients,2013,5(7):2777-2810.  

[30] FORSYTH J S,CARLSON S.Long-chain polyunsaturated fatty acids in infant nutrition:effects on infant development[J].Current Opinion in Clinical Nutrition and Metabolic Care,2001,4(2):123-126.  

[31] YURKO M K,MCCARTHY D,ROM D,et al.Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline[J].Alzheimers & Dement,2010,6(6):456-464.  

[32] CRUPI R,MARINO A,CUZZOCREA S.n-3 fatty acids:role in neurogenesis and neuroplasticity[J].Current Medicinal Chemistry,2013,20(24):2953-2963.  

[33] WU Z X,YU Y H,WU Y Z,et al.Ruduction of histamine H₁ receptor binding induced by high-fat diet can be prevented by DHA and dietary fiber in specific brain areas of male rats[J].Brain Research Bulletin,2013,97:119-125.

[34] JENSEN C L,VOIGT R G,PRAGER T C,et al.Effects of maternal docosahexaenoic acid intake on visual function and neurodevelopment in breastfed term infants[J].American Journal of Clinical Nutrition,2005,82(1):125-132.

[35] GLEISSMAN H,JOHNSEN J I,KOGNER P.Omega-3 fatty acids in cancer,the protectors of good and the killers of evil?[J].Experimental Cell Research,2010,316(8):1365-1373.  

[36] DAI J F,SHEN J H,PAN W S,et al.Effects of polyunsaturated fatty acids on the growth of gastric cancer cells in vitro[J].Lipids in Health and Disease,2013,12(1):71-85.  

[37] SHIN S,JING K P,JEONG S,et al.The omega-3 polyunsaturated fatty acid DHA induces simultaneous apoptosis and autophagy via mitochondrial ROS-mediated Akt-mTOR signaling in prostate cancer cells expressing mutant p53[J].BioMed Research International,2013,doi:10.1155/2013/568671.

[38] GRANCI V,CAI F,LECUMBERRI E,et al.Colon cancer cell chemosensitisation by fish oil emulsion involves apoptotic mitochondria pathway[J].British Journal of Nutrition,2013,109(7):1188-1195.  

[39] ABRAHAO A C,CASTILHO R M,SQUARIZE C H,et al.A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation[J].Oral Oncology,2010,46(12):880-887.  

[40] JUMAN S,HASHIMOTO M,KATAKURA M,et al.Effects of long-term oral administration of arachidonic acid and docosahexaenoic acid on the immune functions of young rats[J].Nutrients,2013,5(6):1949-1961.  

[41] DA BETIATI D S B,DE OLIVEIRA P F,DE CAMARGO C Q,et al.Effects of omega-3 fatty acids on regulatory T cells in hematologic neoplasms[J].Revista Brasileira de Hematologia e Hemoterapia,2013,35(2):119-125.

[42] GABLER N K, SPENCER J D, WEBEL D M,et al.In utero and postnatal exposure to long chain (n-3) PUFA enhances intestinal glucose absorption and energy stores in weanling pigs[J].The Journal of Nutrition,2007,137(11):2351-2358.

[43] LEONARD S G,SWEENEY T,BAHAR B,et al.Effect of dietary seaweed extracts and fish oil supplementation in sows on performance,intestinal microflora,intestinal morphology,volatile fatty acid concentrations and immune status of weaned pigs[J].Nutritional Immunology,2011,105(4):549-560.

[44] 刘玉兰,李德发,龚利敏,等.EPA和DHA对断奶仔猪淋巴细胞转化和细胞内信号分子的影响[J].畜牧兽医学报,2007,38(10):1060-1065.

[45] LI P,KIM S W,LI X L,et al.Dietary supplementation with cholesterol and docosahexaenoic acid increases the activity of the arginine-nitric oxide pathway in tissues of young pigs[J].Nitric Oxide,2008,19(3):259-265.  

[46] LI P,KIM S W,LI X L,et al.Dietary supplementation with cholesterol and docosahexaenoic acid affects concentrations of amino acids in tissues of young pigs[J].Amino Acids,2009,37(4):709-716.  

[47] WEI H K,ZHOU Y F,JIANG S Z,et al.Feeding a DHA-enriched diet increases skeletal muscle protein synthesis in growing pigs:association with increased skeletal muscle insulin action and local mRNA expression of insulin-like growth factor 1[J].British Journal of Nutrition,2013,110(4):671-680.  

[48] CASTELLANO C A,AUDET I,LAFOREST J P,et al.Fish oil diets alter the phospholipid balance,fatty acid composition,and steroid hormone concentrations in testes of adult pigs[J].Theriogenology,2011,76(6):1134-1145.  

[49] 吕玉丽,久保长政,刘建新,等.饲料中添加鱼油对肥育猪脂肪酸组成的影响[J].浙江农业学报,2008,20(6):484-486.

[50] 彭瑛,占今舜,李丽立,等.饲粮中添加DHA复合添加剂对蛋鸡生产性能和蛋品质的影响[J].华南农业大学学报:自然科学版,2012,33(4):539-543.

[51] ALVAREZ C,CACHALDORA P,MNDEZ J,et al.Effects of dietary conjugated linoleic acid and fish oil supplementation on performance and egg quality in laying hens[J].British Poultry Science,2004,45(4):524-529.  

[52] CACHALDORA P,GARCA-REBOLLAR P,ALVAREZ C,et al.Effect of type and level of fish oil supplementation on yolk fat composition and n-3 fatty acids retention efficiency in laying hens[J].British Poultry Science,2006,47(1):43-49.  

[53] LI Y,SUN C.The later effects of DHA in diet on regulating transcription of lipid genes of broiler[J].Agricultural Sciences in China,2011,10(4):611-618.  

[54] HALL J A,JHA S,SKINNER M M,et al.Maternal dietary n-3 fatty acids alter immune cell fatty acid composition and leukotriene production in growing chicks[J].Prostaglandins,Leukotrienes and Essential Fatty Acids,2007,76(1):19-28.  

[55] ALLEN P C, DANFORTH H D.Effects of dietary supplementation with n-3 fatty acid ethyl esters on coccidiosis in chickens[J].Poultry Science,1998,77(11):1631-1635.

[56] 刘仕军,卜登攀,王加启,等.日粮添加LA和DHA对乳脂脂肪酸含量及比值的影响[J].动物营养学报,2008,20(5):515-521.

[57] 王蕾,王加启,卜登攀,等.奶牛日粮添加共轭亚油酸和二十二碳六烯酸对瘤胃纤维素酶活性的影响[J].东北农业大学学报,2009,40(4):65-68.

[58] 刘亮,王加启,卜登攀,等.EPA/DHA对体外发酵及瘤胃液脂肪酸组成的影响[J].中国畜牧兽医,2008,35(7):5-11.

[59] 王蕾,王加启,李发弟,等.日粮添加亚油酸和二十二碳六烯酸对奶牛瘤胃原虫奇数碳链脂肪酸和支链脂肪酸的影响[J].甘肃农业大学学报,2010,45(1):12-15.

[60] 汪留全,胡王,李海洋,等.饲料中DHA与EPA水平对幼蟹生长和饲料利用率的影响[J].渔业现代化,2003(6):39-40,33.

[61] 汪倩,丰浪,刘智俊,等.饲料中DHA/EPA对三疣梭子蟹肝胰腺组织结构的影响[J].广东农业科学,2012,39(15):147-149.

[62] 吉红,周继术,曹福余,等.DHA对鲤抗氧化能力影响的初步研究[J].上海海洋大学学报,2009,18(2):142-149.

[63] 王桂芹,牛小天,卢洪梅,等.饲料中添加VE和DHA对不同养殖密度建鲤生长、摄食和分化的影响[J].吉林农业大学学报,2010,32(5):548-554.

[64] 王桂芹,牛小天,卢洪梅,等.不同维生素E和DHA水平对建鲤免疫力和抗病力的影响[J].中国畜牧杂志,2012,48(3):52-55.

[65] MORENO-INDIAS I,SÁNCHEZ-MACAS D,MARTNEZ-DE LA P J,et al.The effect of diet and DHA addition on the sensory quality of goat kid meat[J].Meat Science,2012,90(2):393-397.