付彤 , 廉红霞 , 高腾云 , 赵卫东 , 孙宇 , 李改英 . 尿素转运因子B影响牛瘤胃尿素氮再循环的机制[J]. 动物营养学报, 2013 , 25(12) : 2798 -2803 . DOI: 10.3969/j.issn.1006-267x.2013.12.003

[1] FAO.Livestock's long shadow:environmental issues and options..http://www.fao.org/docrep/010/a0701e/a0701e00.HTM.

[2] YAN T,FROST J P,AGNEW R E,et al.Relationships among manure nitrogen output and dietary and animal factors in lactating dairy cows[J].Journal of Dairy Science,2006,89(10):3981-3991.  

[3] KOHN R A,DINNEEN M M,RUSSEK-COHEN E,et al.Using blood urea nitrogen to predict nitrogen excretion and efficiency of nitrogen utilization in cattle,sheep,goats,horses,pigs,and rats[J].Journal of Animal Science,2005,83(4):879-889.

[4] MARINI J C,SANDS J M,VAN AMBURGH M E.Urea transporters and urea recycling in ruminants[M]//SEJRSEN K,HVELPLUND T,NIELSEN M O.Ruminant physiology.Wageningen, Netherlands:Wageningen Academic Publishers,2006:155-171.

[5] DORANALLI K,PENNER G B,MUTSVANGWA T.Feeding oscillating dietary crude protein concentrations increases nitrogen utilization in growing lambs and this response is partly attributable to increased urea transfer to the rumen[J].The Journal of Nutrition,2011,141(4):560-567.  

[6] SUNNY N E,OWENS S L,BALDWIN R L,et al.Salvage of blood urea nitrogen in sheep is highly dependent on plasma urea concentration and the efficiency of capture within the digestive tract[J].Journal of Animal Science,2007,85(4):1006-1013.

[7] SIMMONS N L,CHAUDHRY A S,GRAHAM C,et al.Dietary regulation of ruminal bovine UT-B urea transporter expression and localization[J].Journal of Animal Science,2009,87(10):3288-3299.  

[8] TICKLE P,THISTLETHWAITE A,SMITH C P,et al.Novel bUT-B2 urea transporter isoform is constitutively activated[J].American Journal of Physiology:Regulatory,Integrative and Comparative Physiology,2009,297(2):R323-R329.

[9] KIRAN D.Factors regulating urea-nitrogen recycling in ruminants.Ph.D.Thesis.Saskatoon SK:University of Saskatchewan,2010:131.

[10] OBARA Y,DELLOW D W,NOLAN J V.Effects of energy-rich supplements on nitrogen kinetics in ruminants[M]//TSUDA T,SASAKI Y,KAWASHIMA R.Physiological aspects of digestion and metabolism in ruminants.San Diego:Academic Press,1991:515-539.

[11] STEWART G S,SMITH C P.Urea nitrogen salvage mechanisms and their relevance to ruminants,non-ruminants and man[J].Nutrition Research Reviews,2005,18(1):49-62.  

[12] 张莹,郭旭生,丁路明,等.反刍动物尿素氮再循环利用的研究进展[J].动物营养学报,2009,21(5):609-616.

[13] LAPIERRE H,LOBLEY G E.Nitrogen recycling in the ruminant:a review[J].Journal of Dairy Science,2001,84(Suppl.):E223-E236

[14] 徐红蕊,时建青,赵国琦.反刍动物体内尿素氮代谢研究进展[J].畜牧兽医杂志,2006,25(1):23-24,27.

[15] REYNOLDS C K,KRISTENSEN N B.Nitrogen recycling through the gut and the nitrogen economy of ruminants:an asynchronous symbiosis[J].Journal of Animal Science,2008,86(Suppl.):E293-E305.

[16] FIRKINS J L,REYNOLDS C K.Whole animal nitrogen balance in cattle[C]//PFEFFER E,HRISTOV A N.Nitrogen and phosphorus nutrition of cattle.Wallingford,UK:CAB Int.,2005:167-186.

[17] ISOZAKI T,GILLIN A G,SWANSON C E,et al.Protein restriction sequentially induces new urea transport processes in rat initial IMCD[J].The American Journal of Physiology,1994,266(5pt2):F756-F761.

[18] ARCHIBEQUE S L,FREETLY H C,FERRELL C L,et al.Net portal and hepatic flux of nutrients in growing wethers fed high-concentrate diets with oscillating protein concentrations[J].Journal of Animal Science,2007,85(4):997-1005.

[19] YANG B X,BANKIR L,GILLESPIE A,et al.Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B[J].The Journal of Biological Chemistry,2002,277(12):10633-10637.  

[20] SMITH C P,ROUSSELET G.Facilitative urea transporters[J].The Journal of Membrane Biology,2001,183(1):1-14.  

[21] ZIMIN A V,DELCHER A L,FLOREA L,et al.A whole-genome assembly of the domestic cow,Bos taurus[J].Genome Biology,2009,10(4):R42.

[22] NCBI.Bos taurus urea transporter (SLC14A1) gene,complete cds,alternatively spliced.GenBank:AY838799.1,2005.http://www.ncbi.nlm.nih.gov/nuccore/AY838799.1.

[23] UCHIDA S,SOHARA E,RAI T,et al.Impaired urea accumulation in the inner medulla of mice lacking the urea transporter UT-A2[J].Journal of Molecular and Cellular Biology,2005,25(16):7357-7363.  

[24] INOUE H,KOZLOWSKI S D,KLEIN J D,et al.Regulated expression of renal and intestinal UT-B urea transporter in response to varying urea load[J].American Journal of Physiology.Renal Physiology,2005,289(2):F451-F458.

[25] INOUE H,JACKSON S D,VIKULINA T,et al.Identification and characterization of a kidd antigen/UT-B urea transporter expressed in human colon[J].American Journal of Physiology:Renal Physiology,2004,287(1):C30-C35.

[26] LUDDEN P A,STOHRER R M,AUSTIN K J,et al.Effect of protein supplementation on expression and distribution of urea transporter-B in lambs fed low-quality forage[J].Journal of Animal Science,2009,87(4):1354-1365.  

[27] STEWART G S,GRAHAM C,CATTELL S,et al.UT-B is expressed in bovine rumen:Potential role in ruminal urea transport[J].American Journal of Physiology:Regulatory,Integrative and Comparative Physiology,2005,289(2):R605-R612.

[28] OBA M,BALDWIN Ⅵ R L,OWENS S L,et al.Metabolic fates of ammonia-N in ruminal epithelial and duodenal mucosal cells isolated from growing sheep[J].Journal of Dairy Science,2005,88(11):3963-3970.  

[29] RØJEN B A,POULSEN S B,THEIL P K,et al.Short communication:effects of dietary nitrogen concentration on messenger RNA expression and protein abundance of urea transporter-B and aquaporins in ruminal papillae from lactating Holstein cows[J].Journal of Dairy Science,2011,94(5):2587-2591.  

[30] THORLACIUS S O,DOBSON A,SELLERS A F.Effect of carbon dioxide on urea diffusion through bovine ruminal epithelium[J].The American Journal of Physiology,1971,220(1):162-170.

[31] ABDOUN K,STUMPFF F,RABBANI I,et al.Modulation of urea transport across sheep rumen epithelium in vitro by SCFA and CO₂[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2010,298(2):G190-G202.

[32] OBA M,BALDWIN Ⅵ R L,OWENS S L,et al.Urea synthesis by ruminal epithelial and duodenal mucosal cells from growing sheep[J].Journal of Dairy Science,2004,87(6):1803-1805.