综述 Review

β-胡萝卜素-15,15’-加氧酶在动物营养及遗传领域的研究进展

  • 魏巧丽 ,
  • 成海建 ,
  • 游伟 ,
  • 崔秀梅 ,
  • 林雪彦 ,
  • 谭秀文 ,
  • 刘桂芬 ,
  • 刘晓牧 ,
  • 宋恩亮 ,
  • 万发春
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  • 1. 山东省农业科学院畜牧兽医研究所, 济南 250100;
    2. 山东省畜禽疫病防治与繁育重点实验室, 济南 250100;
    3. 山东农业大学动物科技学院, 泰安 271018

收稿日期: 2013-06-07

  网络出版日期: 2013-11-19

基金资助

国家自然科学基金(31172232);山东省优秀中青年科学家科研奖励基金(BS2011SW043);现代农业(肉牛牦牛)产业技术体系建设专项资金(CARS-38)

Research Progress of β-Carotene-15,15’-Momoxygenase in Animal Nutrition and Genetic Fields

  • WEI Qiaoli ,
  • CHENG Haijian ,
  • YOU Wei ,
  • CUI Xiumei ,
  • LIN Xueyan ,
  • TAN Xiuwen ,
  • LIU Guifen ,
  • LIU Xiaomu ,
  • SONG Enliang ,
  • WAN Fachun
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  • 1. Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, China;
    2. Shandong Key Laboratory of Animal Disease Control and Breeding, Jinan 250100, China;
    3. College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China

Received date: 2013-06-07

  Online published: 2013-11-19

摘要

β-胡萝卜素-15,15'-加氧酶(β-carotene-15,15'-momoxygenase 1,BCMO1)是将具有维生素A原活性的类胡萝卜素转化为维生素A的关键酶,所以该酶对人以及动物体的消化吸收、代谢转运、生长发育以及免疫调节等有着重要影响。此外,BCMO1基因的转录因子过氧化物酶体增殖激活受体(PPAR)通过控制该基因的表达来调节体内脂肪细胞分化以及脂肪和葡萄糖代谢。本文综述了国内外关于BCMO1在体内的分布、作用机制、调控因素等方面的研究进展。

本文引用格式

魏巧丽 , 成海建 , 游伟 , 崔秀梅 , 林雪彦 , 谭秀文 , 刘桂芬 , 刘晓牧 , 宋恩亮 , 万发春 . β-胡萝卜素-15,15’-加氧酶在动物营养及遗传领域的研究进展[J]. 动物营养学报, 2013 , 25(12) : 2838 -2843 . DOI: 10.3969/j.issn.1006-267x.2013.12.009

Abstract

β-carotene-15,15'-momoxygenase 1 (BCMO1)is a key enzyme to convert provitamin A carotenoid into retinal, and has a great effect on digestion and absorption, metabolism and transport, growth and development,and immune regulation in human and animals. The transcription factor of BCMO1 gene, peroxisome proliferator activated receptor (PPAR), regulated adipocyte differentiation and lipid and glucose metabolism by the regulation of this gene expression. This paper reviewed the research progress on the distribution, mechanism of action and regulative factors of BCMO1 at home and abroad.

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