表皮生长因子对肠道功能调控的研究

刘淑杰; 徐子伟; 齐珂珂; 吴杰

doi:10.3969/j.issn.1006-267x.2014.03.002

动物营养学报 >

2014 , Vol. 26 >Issue 3: 565 - 570

DOI: https://doi.org/10.3969/j.issn.1006-267x.2014.03.002

综述 Review

表皮生长因子对肠道功能调控的研究

刘淑杰 ,
徐子伟 ,
齐珂珂 ,
吴杰

展开

浙江省农业科学院畜牧兽医研究所, 杭州 310021

收稿日期: 2013-10-08

网络出版日期: 2014-03-04

基金资助

国家现代农业产业技术体系（CARS-36）；国家青年科学基金项目（C170105/31101724）；浙江省自然科学基金（LQ12C17004）

收起

Regulation of Epidermal Growth Factor on Intestinal Functions

LIU Shujie ,
XU Ziwei ,
QI Keke ,
WU Jie

Expand

Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China

Received date: 2013-10-08

Online published: 2014-03-04

Fold

摘要

肠道健康决定了动物的整体机能和生产力水平，改善肠道结构与功能对动物健康生长具有重要意义。在畜牧生产中，诸多因素均能导致动物肠道功能损伤、生产力降低和抗病力减弱。表皮生长因子是促生长因子家族成员之一，具有许多生物学作用。表皮生长因子作为有丝分裂原，可刺激细胞分裂、增殖，增加上皮组织的DNA与蛋白质合成等，其独特作用是促进肠道组织生长、发育及损伤后修复，与动物肠道结构和功能密切相关。本文主要就表皮生长因子介导的信号通路、促进肠道发育、修复受损肠道组织、影响肠道各种酶活性以及提高营养物质消化吸收等方面内容进行论述。

关键词： 表皮生长因子; 肠道; 信号通路; 功能调控

本文引用格式

刘淑杰 , 徐子伟 , 齐珂珂 , 吴杰 . 表皮生长因子对肠道功能调控的研究[J]. 动物营养学报, 2014 , 26(3) : 565 -570 . DOI: 10.3969/j.issn.1006-267x.2014.03.002

Abstract

Gastrointestinal health of animals determines their overall level of function and productivity, and the improvement of structure and function in intestine has a great influence on healthy growth of animals. However, some factors can cause intestinal injury, reduction of growth performance and immunity in animal production. Epidermal growth factor (EGF) is one of growth factor family members, which has many biological functions. EGF can stimulate cellular proliferation and differentiation, and enhance protein and DNA synthesis of epithelial tissues. The unique roles of EGF are promoting growth and development and repairing damage of the intestinal tract, which are related to intestinal structure and function. This paper reviewed the mediated signal pathways by EGF, and its biological functions such as promoting intestinal development, repairing damaged intestine, affecting enzyme activities in intestinal tract and improving digestion and absorption of nutrients.

Key words： epidermal growth factor; intestinal tract; signaling pathway; functional regulation

参考文献

[1] COHEN S.Purification of a nerve-growth promoting protein from the mouse salivary gland and its neuro-cytotoxic antiserum[J].Proceedings of the National Academy of Sciences of the United States of America, 1960, 46(3):302-311.

[2] 王镜岩, 朱圣庚, 徐长法.生物化学[M].3版.北京:高等教育出版社, 2002:559.

[3] BERSETH C L.Enhancement of intestinal growth in neonatal rats by epidermal growth fact or in milk[J].American Journal of Physiology, 1987, 253(5):662-665.

[4] DUH G, MOURI N, WARBURTON D, et al.EGF regulates early embryonic mouse gut development in chemically defined organ culture[J].Pediatric Research, 2000, 48(6):794-802.

[5] WARNER B W, WARNER B B.Role of epidermal growth factor in the pathogenesis of neonatal necrotizing enterocolitis[J].Seminars in Pediatric Surgery, 2005, 14(3):175-180.

[6] MIETTINEN P J, BERGER J E, MENESES J, et al.Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor[J].Nature, 1995, 376:337-341.

[7] KITCHEN P A, GOODLAD R A, FITZGERALD A J, et al.Intestinal growth in parenterally-fed rats induced by the combined effects of glucagon-like peptide 2 and epidermal growth factor[J].Journal of Parenteral and Enteral Nutrition, 2005, 29(4):248-254.

[8] OHUMURA E, EMOTO N, TSUSHIMA T, et al.Salivary immunoreactive human epidermal growth factor (IR-HEGF) in patients with peptic ulcer disease[J].Hepatogastroenterology, 1987, 34(4):160-163.

[9] WARNER B, ERWIN C R.Critical roles for EGF receptor signaling during resection-induced small bowel adaptation[J].Journal of Pediatric Gastroenterology and Nutrition, 2006, 43(Suppl.1):68-73.

[10] TARNAWSKI A, STACHURA J, DURBIN T, et al.Increased expression of epidermal growth factor receptor during gastric ulcer healing in rats[J].Gastroenterology, 1992, 102(2):695-698.

[11] ABUD H E, WATSON N, HEATH J K.Growth of intestinal epithelium in organ culture is dependent on EGF signaling[J].Experimental Cell Research, 2005, 303(2):252-262.

[12] MAYNARD A A, DVORAK K, KHAILOVA L, et al.Epidermal growth factor reduces autophagy in intestinal epithelium and in the rat model of necrotizing enterocolitis[J].American Journal of Physiology:Gastrointestinal and Liver Physiology, 2010, 299(3): 614-622.

[13] 耿艳霞, 黎介寿, 李秋荣, 等.表皮生长因子对大鼠小肠缺血-再灌注损伤的保护作用[J].肠外与肠内营养, 2013, 20(1):29-32.

[14] 李垚, 单安山, 李焕江, 等.表皮生长因子和胰岛素样生长因子-Ⅰ对21日龄断奶仔猪胃和小肠发育的作用[J].动物营养学报, 2005, 17(3):44-49.

[15] ODLE J, ZIJLSTRA R T, DONOVAN S M.Intestinal effects of milkborne growth factors in neonates of agricultural importance[J].Journal of Animal Science.1996, 74(10):2509-2522.

[16] JAMES P S, SMITH M W, TIVEY D R, et al.Epidermal growth factor selectively increases maltase and sucrase activities in neonatal piglet intestine[J].The Journal of Physiology, 1987, 393:583-594.

[17] BURET A, OLSON M E, GALL D G, et al.Effects of orally administered epidermal growth factor on enteropathogenic Escherichia coli infection in rabbits[J].Infection and Immunity, 1998, 66(10):4917-4923.

[18] JAEGER L A, LAMAR C H, CLINE T R, et al.Effect of orally administered epidermal growth factor on the jejunal mucosa of weaned pigs[J].American Journal of Veterinary Research, 1990, 51(3):471-474.

[19] 董光龙, 王俊义, 王为忠, 等.表皮生长因子对放射性肠炎全肠外营养大鼠谷氨酰胺代谢酶的影响[J].第四军医大学学报, 2000, 21(8):1008-1011.

[20] CELLINI C, XU J, ARRIAGA A, et al.Effect of epidermal growth factor infusion on fetal rabbit intrauterine growth retardation and small intestinal development[J].Journal of Pediatric Surgery, 2004, 39(6):891-897.

[21] CELLINI C, XU J, BUCHMILLER-CRAIR T.Effect of epidermal growth factor on small intestinal sodium/glucose cotransporter-1 expression in a rabbit model of intrauterine growth retardation[J].Journal of Pediatric Surgery, 2005, 40(12):1892-1897.

[22] OKUYAMA H, URAO M, LEE D, et al.The effect of epidermal growth factor on bacterial translocation in newborn rabbits[J].Journal of Pediatric Surgery, 1998, 33(2):225-228.

[23] AlBANESE C T, CARDONA M, SMITH S D, et al.Role of intestinal mucus in transepithelial passage of bacteria across the intact ileum in vitro[J].Surgery, 1994, 116(1):76-82.

[24] LAMB-ROSTESKI J M, KALISCHUK L D, INGLIS G D, et al.Epidermal growth factor inhibits Campylobacter jejuni-induced claudin-4 disruption, loss of epithelial barrier function, and Escherichia coli translocation[J].Infection and Immunity, 2008, 76(8):3390-3398.

[25] BURET A, OLSON M E, GALL D G, et al.Effects of orally administered epidermal growth factor on enteropathogenic Escherichia coli infection in rabbits[J].Infection and Immunity, 1998, 66(10):4917-4923.

[26] 赖俊浩, 王俊义, 张国祥.表皮生长因子对全胃肠外营养大鼠肠道细菌易位的影响及其机制[J].中华创伤杂志, 1999, 15(2):133-135.

Options

文章导航

摘要

本文引用格式

Abstract

参考文献

关于本刊

在线期刊

作者中心

相关单位

联系我们

模态框（Modal）标题

摘要

本文引用格式

Abstract

参考文献

关于本刊

在线期刊

作者中心

相关单位

联系我们