陈浩 , 毛湘冰 , 陈代文 , 余冰 , 汤俊 . 亮氨酸调节哺乳动物脂肪代谢的研究进展[J]. 动物营养学报, 2014 , 26(7) : 1723 -1727 . DOI: 10.3969/j.issn.1006-267x.2014.07.002

[1] CROZIER S J,KIMBALL S R,EMMERT S W,et al.Oral leucine administration stimulates protein synthesis in rat skeletal muscle[J].The Journal of Nutrition,2005,135(3):376-382.

[2] DU M,SHEN Q W,ZHU M J,et al.Leucine stimulates mammalian target of rapamycin signaling in C₂C₁₂ myoblasts in part through inhibition of adenosine monophosphate-activated protein kinase[J].Journal of Animal Science,2007,85(4):919-927.

[3] SURYAWAN A,JEYAPALAN A S,ORELLANA R A,et al.Leucine stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing mTORC1 activation[J].American Journal of Physiology-Endocrinology and Metabolism,2008,295(4):E868-E875.

[4] HAN B,TONG J,ZHU M J,et al.Insulin-like growth factor-1 (IGF-1) and leucine activate pig myogenic satellite cells through mammalian target of rapamycin (mTOR) pathway[J].Molecular Reproduction and Development,2008,75(5):810-817.  

[5] NORTON L E,LAYMAN D K,BUNPO P,et al.The leucine content of a complete meal directs peak activation but not duration of skeletal muscle protein synthesis and mammalian target of rapamycin signaling in rats[J].The Journal of Nutrition,2009,139(6):1103-1109.  

[6] MITCHELL J C,EVENSON A R,TAWA N E,Jr.Leucine inhibits proteolysis by the mTOR kinase signaling pathway in skeletal muscle[J].Journal of Surgical Research,2004,121(2):311.

[7] VENTRUCCI G,MELLO M A R,GOMES-MARCONDES M C C.Proteasome activity is altered in skeletal muscle tissue of tumour-bearing rats a leucine-rich diet[J].Endocrine-related Cancer,2004,11(4):887-895.  

[8] NAKASHIMA K,ISHIDA A,YAMAZAKI M,et al.Leucine suppresses myofibrillar proteolysis by down-regulating ubiquitin-proteasome pathway in chick skeletal muscles[J].Biochemical and Biophysical Research Communications,2005,336(2):660-666.  

[9] SUGAWARA T,ITO Y,NISHIZAWA N,et al.Supplementation with dietary leucine to a protein-deficient diet suppresses myofibrillar protein degradation in rats[J].Journal of Nutritional Science and Vitaminology,2007,53(6):552-555.  

[10] SUGAWARA T,ITO Y,NISHIZAWA N,et al.Regulation of muscle protein degradation,not synthesis,by dietary leucine in rats fed a protein-deficient diet[J].Amino Acids,2009,37(4):609-616.  

[11] 毛湘冰,黄志清,陈小玲,等.亮氨酸调节哺乳动物骨骼肌蛋白质合成的研究进展[J].动物营养学报,2011,23(5):709-714.

[12] LÓPEZ N,SÁNCHEZ J,PICÓ C,et al.Dietary L-leucine supplementation of lactating rats results in a tendency to increase lean/fat ratio associated to lower orexigenic neuropeptide expression in hypothalamus[J].Peptides,2010,31(7):1361-1367.  

[13] FREUDENBERG A,PETZKE K J,KLAUS S.Dietary l-leucine and l-alanine supplementation have similar acute effects in the prevention of high-fat diet-induced obesity[J].Amino Acids,2013,44(2):519-528.  

[14] ZHANG Y,GUO K,LEBLANC R E,et al.Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms[J].Diabetes,2007,56(6):1647-1654.  

[15] VIANNA D,RESENDE G F T,TORRES-LEAL F L,et al.Long-term leucine supplementation reduces fat mass gain without changing body protein status of aging rats[J].Nutrition,2012,28(2):182-189.  

[16] QIN L Q,XUN P,BUJNOWSKI D,et al.Higher branched-chain amino acid intake is associated with a lower prevalence of being overweight or obese in middle-aged East Asian and Western adults[J].The Journal of Nutrition,2011,141(2):249-254.  

[17] LAYMAN D K,WALKER D A.Potential importance of leucine in treatment of obesity and the metabolic syndrome[J].The Journal of Nutrition,2006,136(1S1):319S-323S.

[18] PARKER B,NOAKES M,LUSCOMBE N,et al.Effect of a high-protein,high-monounsaturated fat weight loss diet on glycemic control and lipid levels in type 2 diabetes[J].Diabetes Care,2002,25(3):425-430.  

[19] LAYMAN D K,EVANS E,BAUM J I,et al.Dietary protein and exercise have additive effects on body composition during weight loss in adult women[J].The Journal of Nutrition,2005,135(8):1903-1910.

[20] ZEMEL M B,BRUCKBAUER A.Effects of a leucine and pyridoxine-containing nutraceutical on fat oxidation,and oxidative and inflammatory stress in overweight and obese subjects[J].Nutrients,2012,4(6):529-541.

[21] SUN X,ZEMEL M B.Leucine and calcium regulate fat metabolism and energy partitioning in murine adipocytes and muscle cells[J].Lipids,2007,42(4):297-305.  

[22] SUN X,ZEMEL M B.Leucine modulation of mitochondrial mass and oxygen consumption in skeletal muscle cells and adipocytes[J].Nutrition & Metabolism,2009,6:26.

[23] CHEN Q,REIMER R A.Dairy protein and leucine alter GLP-1 release and mRNA of genes involved in intestinal lipid metabolism in vitro[J].Nutrition,2009,25(3):340-349.  

[24] ZEANANDIN G,BALAGE M,SCHNEIDER S M,et al.Differential effect of long-term leucine supplementation on skeletal muscle and adipose tissue in old rats:an insulin signaling pathway approach[J].Age,2012,34(2):371-387.  

[25] NOATSCH A,PETZKE K J,MILLROSE M K,et al.Body weight and energy homeostasis was not affected in C57BL/6 mice fed high whey protein or leucine-supplemented low-fat diets[J].European Journal of Nutrition,2011,50(6):479-488.  

[26] NAIRIZI A,SHE P,VARY T C,et al.Leucine supplementation of drinking water does not alter susceptibility to diet-induced obesity in mice[J].The Journal of Nutrition,2009,139(4):715-719.  

[27] CHENG Y,MENG Q,WANG C,et al.Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue[J].Diabetes,2010,59(1):17-25.  

[28] XIA T,CHENG Y,ZHANG Q,et al.S6K1 in the central nervous system regulates energy expenditure via MC4R/CRH pathways in response to deprivation of an essential amino acid[J].Diabetes,2012,61(10):2461-2471.  

[29] CHENG Y,ZHANG Q,MENG Q,et al.Leucine deprivation stimulates fat loss via increasing CRH expression in the hypothalamus and activating the sympathetic nervous system[J].Molecular Endocrinology,2011,25(9):1624-1635.  

[30] KOH E H,PARK J Y,PARK H S,et al.Essential role of mitochondrial function in adiponectin synthesis in adipocytes[J].Diabetes,2007,56(12):2973-2981.  

[31] OTABE S,YUAN X,FUKUTANI T,et al.Overexpression of human adiponectin in transgenic mice results in suppression of fat accumulation and prevention of premature death by high-calorie diet[J].American Journal of Physiology:Endocrinology and Metabolism,2007,293(1):E210-E218.

[32] PICARD F,KURTEV M,CHUNG N,et al.Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ[J].Nature,2004,429(6993):771-776.  

[33] PICARD F,GUARENTE L.Molecular links between aging and adipose tissue[J].International Journal of Obesity,2005,29(S1):S36-S39.

[34] MCALLAN L,COTTER P D,ROCHE H M,et al.Impact of leucine on energy balance[J].Journal of Physiology and Biochemistry,2013,69(1):155-163.  

[35] ZHANG Q,LIU B,CHENG Y,et al.Leptin signaling is required for leucine deprivation-enhanced energy expenditure[J].Journal of Biological Chemistry,2014,289(3):1779-1787.