[1] MINTON K.Metabolism:role for mTORC2 in insulin resistance[J].Nature Reviews Molecular Cell Biology,2013,14(2):67.
[2] FINLAY M R V,GRIFFIN R J.Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family[J].Bioorganic & Medicinal Chemistry Letters,2012,22(17):5352-5359.
[3] MOK K W,MRUK D D,LEE W M,et al.Rictor/mTORC2 regulates blood-testis barrier dynamics via its effects on gap junction communications and actin filament network[J].The FASEB Journal,2013,27(3):1137-1152.
[4] WU D,CHAPMAN J R,WANG L F,et al.Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of raptor Thr-908[J].The Journal of Biological Chemistry,2012,287(15):12510-12519.
[5] DENNIS M D,BAUM J I,KIMBALL S R,et al.Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids[J].The Journal of Biological Chemistry,2011,286(10):8287-8296.
[6] GORDON B S,KAZI A A,COLEMAN C S,et al.RhoA regulates the mechanistic target of rapamycin complex 1 (mTORC1)[J].The FASEB Journal,2013,27:603.
[7] LI L,KIM E,YUAN H X,et al.Regulation of mTORC1 by the rab and Arf GTPases[J].The Journal of Biological Chemistry,2010,285(26):19705-19709.
[8] YANG H J,RUDGE D G,KOOS J D,et al.mTOR kinase structure,mechanism and regulation[J].Nature,2013,497(7448):217-223.
[9] VAREA O,ESCOLL M,DIEZ H,et al.Oestradiol signalling through the Akt-mTORC1-S6K1[J].Biochimica at Biophysica Acta,2013,1833(5):1052-1064.
[10] LIU Y,VERTOMMEN D,RIDER M H,et al.Mammalian target of rapamycin-independent S6K1 and 4E-BP1 phosphorylation during contraction in rat skeletal muscle[J].Cellular Signalling,2013,25(9):1877-1886.
[11] DESTEFANO M A,JACINTO E.Regulation of insulin receptor substrate-1 by mTORC2 (mammalian target of rapamycin complex 2)[J].Biochemical Society Transactions,2013,41(4):896-901.
[12] SCIASCIA Q,PACHECO D,MCCOARD S A.Increased milk protein synthesis in response to exogenous growth hormone is associated with changes in mechanistic (mammalian) target of rapamycin (mTOR) C1-dependent and independent cell signaling[J].Journal of Dairy Science,2013,96(4):2327-2338.
[13] KRYMSKAYA V P,SNOW J,CESARONE G,et al.mTOR is required for pulmonary arterial vascular smooth muscle cell proliferation under chronic hypoxia[J].The FASEB Journal,2011,25(6):1922-1933.
[14] ESEN E,CHEN J,KARNER C M,et al.WNT-LRP5 signaling induces warburg effect through mTORC2 activation during osteoblast differentiation[J].Cell Metabolism,2013,17(5):745-755.
[15] LIU P,GAN W,INUZUKA H,et al.Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis[J].Nature Cell Biology,2013,15(11):1340-1350.
[16] ZINZALLA V,STRACKA D,OPPLIGER W,et al.Activation of mTORC2 by association with the ribosome[J].Cell,2011,144(5):757-768.
[17] KHANNA N,FANG Y M,YOON M S,et al.XPLN is a novel regulator of mTORC2[J].The FASEB Journal,2013,27:831.
[18] SUZUKI K,AKIOKA M,KONDO-KAKUTA C,et al.Fine mapping of autophagy-related proteins during autophagosome formation in
Saccharomyces cerevisiae[J].Journal of Cell Science,2013,126(11):2534-2544.
[19] VELIKKAKATH A K G,NISHIMURA T,OITA E,et al.Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets[J].Molecular Biology of the Cell,2012,23(5):896-909.
[20] JIN M,KLIONSKY D J.The core molecular machinery of autophagosome formation[M]//WANG H G.Autophagy and cancer.New York:Springer,2013,8:25-45.
[21] KOYAMA-HONDA I,ITAKURA E,FUJIWARA T K,et al.Temporal analysis of recruitment of mammalian ATG proteins to the autophagosome formation site[J].Autophagy,2013,9(10):1491-1499.
[22] TANIDA I.Autophagosome formation and molecular mechanism of autophagy[J].Antioxidants & Redox Signaling,2011,14(11):2201-2214.
[23] RAVIKUMAR B,MOREAU K,JAHREISS L,et al.Plasma membrane contributes to the formation of pre-autophagosomal structures[J].Nature Cell Biology,2010,12(8):747-757.
[24] NAKATOGAWA H,OHBAYASHI S,SAKOH-NAKATOGAWA M,et al.The autophagy-related protein kinase Atg1 interacts with the ubiquitin-like protein Atg8 via the Atg8 family interacting motif to facilitate autophagosome formation[J].The Journal of Biological Chemistry,2012,287(34):28503-28507.
[25] TANG H W,WANG Y B,WANG S L,et al.Atg1-mediated myosin Ⅱ activation regulates autophagosome formation during starvation-induced autophagy[J].The EMBO Journal,2011,30(4):636-651.
[26] DESELM C J,MILLER B C,ZOU W,et al.Autophagy proteins regulate the secretory component of osteoclastic bone resorption[J].Developmental Cell,2011,21(5):966-974.
[27] NAKAHIRA K,HASPEL J A,RATHINAM V A,et al.Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome[J].Nature Immunology,2011,12(3):222-230.
[28] BESTEIRO S,BROOKS C F,STRIEPEN B,et al.Autophagy protein Atg3 is essential for maintaining mitochondrial integrity and for normal intracellular development of
Toxoplasma gondii tachyzoites[J].PLoS Pathogens,2011,7(12):E1002416.
[29] MORTENSEN M,SOILLEUX E J,DJORDJEVIC G,et al.The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance[J].The Journal of Experimental Medicine,2011,208(3):455-467.
[30] RUBINSTEIN A D,EISENSTEIN M,BER Y,et al.The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis[J].Molecular Cell,2011,44(5):698-709.
[31] LEFEBVRE V,DU Q,BAIRD S,et al.Genome-wide RNAi screen identifies ATPase inhibitory factor 1 (ATPIF1) as essential for PARK2 recruitment and mitophagy[J].Autophagy,2013,9(11):1770-1779.
[32] YOULE R J,NARENDRA D P.Mechanisms of mitophagy[J].Nature Reviews Molecular Cell Biology,2011,12(1):9-14.
[33] GEISLER S,HOLMSTRM K M,SKUJAT D,et al.PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1[J].Nature Cell Biology,2010,12(2):119-131.
[34] JIN S M,YOULE R J.The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria[J].Autophagy,2013,9(11):1750-1757.
[35] EGAN D F,SHACKELFORD D B,MIHAYLOVA M M,et al.Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy[J].Science,2011,331(6016):456-461.
[36] WRIGHTON K H.Metabolism:putting energy into mitophagy[J].Nature Reviews Molecular Cell Biology,2013,14(6):324-324.
[37] KRAFT C,DEPLAZES A,SOHRMANN M,et al.Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease[J].Nature Cell Biology,2008,10(5): 602-610.
[38] SUZUKI K.Selective autophagy in budding yeast[J].Cell Death & Differentiation,2012,20(1):43-48.
[39] FUJIWARA Y,KIKUCHI H,AIZAWA S,et al.Direct uptake and degradation of DNA by lysosomes[J].Autophagy,2013,9(8):1167-1171.
[40] OSSAREH-NAZARI B,BONIZEC M,COHEN M,et al.Cdc48 and Ufd3,new partners of the ubiquitin protease Ubp3,are required for ribophagy[J].EMBO Reports,2010,11(7):548-554.
[41] BAKOWSKA-?Z . YWICKA? K,TYCZEWSKA A.Ribophagy-the novel degradation system of the ribosome[J].Biotechnologia,2009,1(84):99-103.
[42] MOTLEY A M,NUTTALL J M,HETTEMA E H.Atg36:the
Saccharomyces cerevisiae receptor for pexophagy[J].Autophagy,2012,8(11):1680-1681.
[43] DENG Y Z,QU Z W,HE Y L,et al.Sorting nexin Snx41 is essential for and mediates glutathione-based antioxidant defense during invasive growth in
Magnaporthe oryzae[J].Autophagy,2012,8(7):1058-1070.
[44] MANJITHAYA R,JAIN S,FARR J C,et al.A yeast MAPK cascade regulates pexophagy but not other autophagy pathways[J].The Journal of Cell Biology,2010,189(2):303-310.
[45] DENG Y Z,QU Z W,NAQVI N I.The role of Snx41-based pexophagy in magnaporthe development[J].PloS One,2013,8(11):e79128.
[46] GRUNAU S,LAY D,MINDTHOFF S,et al.The phosphoinositide 3-kinase Vps34p is required for pexophagy in
Saccharomyces cerevisiae[J].Biochemical Journal,2011,434(1):161-170.
[47] FU L L,WEN X,BAO J K,et al.MicroRNA-modulated autophagic signaling networks in cancer[J].The International Journal of Biochemistry & Cell Biology,2012,44(5):733-736.
[48] TEKIRDAG K A,KORKMAZ G,OZTURK D G,et al.MIR181A regulates starvation-and rapamycin-induced autophagy through targeting of ATG5[J].Autophagy,2013,9(3):374-385.
[49] KORKMAZ G,LE SAGE C,TEKIRDAG K A,et al.miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1[J].Autophagy,2012,8(2):165-176.
[50] KOVALEVA V,MORA R,PARK Y J,et al.miRNA-130a targets ATG2B and DICER1 to inhibit autophagy and trigger killing of chronic lymphocytic leukemia cells[J].Cancer Research,2012,72(7):1763-1772.
[51] KIJANSKA M,PETER M.Atg1 kinase regulates early and late steps during autophagy[J].Autophagy,2013,9(2):249-251.
[52] JUNG C H,JUN C B,RO S H,et al.ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery[J].Molecular Biology of the Cell,2009,20(7):1992-2003.
[53] EGAN D,KIM J,SHAW R J,et al.The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR[J].Autophagy,2011,7(6):643-644.
[54] WU L L,FENG Z,CUI S Y,et al.Rapamycin upregulates autophagy by inhibiting the mTOR-ULK1 pathway,resulting in reduced podocyte injury[J].PloS One,2013,8(5):e63799 .
[55] KATSIARIMPA A,KALINOWSKA K,ANZENBERGER F,et al.The deubiquitinating enzyme AMSH1 and the ESCRT-Ⅲ subunit VPS2.1 are required for autophagic degradation in Arabidopsis[J].The Plant Cell,2013,25(6):2236-2252.
[56] NAZIO F,STRAPPAZZON F,ANTONIOLI M,et al.mTOR inhibits autophagy by controlling ULK1 ubiquitylation,self-association and function through AMBRA1 and TRAF6[J].Nature Cell Biology,2013,15(4):406-416.
[57] HUANG H,KANG R Y,WANG J,et al.Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC),the mechanistic target of rapamycin (MTOR) pathway,through endoplasmic reticulum stress to induce autophagy[J].Autophagy,2013,9(2):175-195.
[58] CHEN Y Q,WEI H J,LIU F,et al.Hyperactivation of mammalian target of rapamycin complex 1 (mTORC1) promotes breast cancer progression through enhancing glucose starvation-induced autophagy and Akt signaling[J].The Journal of Biological Chemistry,2014,289(2):1164-1173.
[59] CHOI J,JO M ,LEE E,et al.AKT is involved in granulosa cell autophagy regulation via mTOR signaling during rat follicular development and atresia[J].Reproduction,2014,147(1):73-80.
[60] LAVALLARD V J,MEIJER A J,CODOGNO P,et al.Autophagy,signaling and obesity[J].Pharmacological Research,2012,66(6):513-525.
[61] LINARES J F,DURAN A,YAJIMA T,et al.K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells[J].Molecular Cell,2013,51(3):283-296.
[62] KOREN I,REEM E,KIMCHI A.Autophagy gets a brake:DAP1,a novel mTOR substrate,is activated to suppress the autophagic process[J].Autophagy,2010,6(8):1179-1180.
京公网安备 11010802041926号