综述 Review

益生菌与动物肠道自由基的关系

  • 王进波 ,
  • 初佳丽 ,
  • 齐莉莉 ,
  • 杨在宾
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  • 1. 浙江大学宁波理工学院, 宁波 315100;
    2. 山东农业大学, 泰安 271018

收稿日期: 2014-06-12

  网络出版日期: 2014-12-05

基金资助

国家自然科学基金项目(31272461,31301984);宁波市科技计划项目(2013C11031,2012A610146)

The Relationship between Probiotics and Animal Intestinal Free Radical

  • WANG Jinbo ,
  • CHU Jiali ,
  • QI Lili ,
  • YANG Zaibin
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  • 1. Ningbo Institute of Technology, Zhejiang University, Ningbo 315100, China;
    2. Shandong Agricultural University, Tai'an 271018, China

Received date: 2014-06-12

  Online published: 2014-12-05

摘要

动物肠道益生菌具有免疫调节、形成肠黏膜上皮屏障功能和刺激肠道细胞增殖等多种生理作用.最新研究表明,益生菌一个重要作用机制是可通过调控肠道自由基的水平,既可发挥免疫调节作用,又避免了对肠道产生氧化损伤.益生菌能够刺激肠道细胞产生活性氧自由基(ROS),ROS参与调控肠道细胞内的氧化还原反应过程.同时,益生菌也能够利用其体内相关的酶系,清除肠道细胞产生的过量ROS,从而防止其对肠道的损伤作用.本文对益生菌通过调控肠道自由基水平,既可发挥免疫调节作用,又防止对肠道氧化损伤的功能及其相关机制进行了综述.

关键词: 益生菌; 肠道; 自由基

本文引用格式

王进波 , 初佳丽 , 齐莉莉 , 杨在宾 . 益生菌与动物肠道自由基的关系[J]. 动物营养学报, 2014 , 26(12) : 3545 -3549 . DOI: 10.3969/j.issn.1006-267x.2014.12.001

Abstract

Probiotics play many physiological functions, such as immune regulation, epithelial barrier formation and cell proliferation in the intestines. The recent researches showed that probiotics could regulate the level of reactive oxygen species (ROS) in the gut, which may be the important mechanism of probiotics to play the physiological functions. Probiotics can stimulate the release of ROS in the intestines, as signaling secondary messengers to regulate the intestinal redox process. Meanwhile probiotics can eliminate the excessive ROS released by intestinal cells to prevent the intestinal damage caused by ROS. This paper reviewed how probiotics regulate the level of ROS in the gut, and perform both immunity and antioxidant functions.

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