[1] RICCIONI G,D'ORAZIO N,SPERANZA L,et al.Carotenoids and asymptomatic carotid atherosclerosis[J].Journal of Biological Regulators and Homeostatic Agents,2010,24(4):447-452.
[2] VILLAÇA CHAVES G,GONÇALVES DE SOUZA G,CARDOSO DE MATOS A,et al.Serum retinol and β-carotene levels and risk factors for cardiovascular disease in morbid obesity[J].International Journal for Vitamin and Nutrition Research,2010,80(3):159-167.

[3] WEGNER A,KHORAMNIA R.Cataract is a self-defence reaction to protect the retina from oxidative damage[J].Medical Hypotheses,2011,76(5):741-744.

[4] ZHOU H Y,ZHAO X F,JOHNSON E J,et al.Serum carotenoids and risk of age-related macular degeneration in a Chinese population sample[J].Investigative Ophthalmology and Visual Science,2011,52(7):4338-4344.

[5] SAHINA N,AKDEMIR F,ORHAN C,et al.Lycopene-enriched quail egg as functional food for humans[J].Food Research International,2008,41(3):295-300.

[6] PAETAU I,KHACHIK F,BROWN E D,et al.Chronic ingestion of lycopene-rich tomato juice or lycopene supplements significantly increases plasma concentrations of lycopene and related tomato carotenoids in humans[J].The American Journal of Clinical Nutrition,1998,68(6):1187-1195.
[7] KARADAS F,PAPPAS A C,SURAI P F,et al.Embryonic development within carotenoid-enriched eggs influences the post-hatch carotenoid status of the chicken[J].Comparative Biochemistry and Physiology Part B:Biochemistry and Molecular Biology,2005,141(2):244-251.

[8] INBARAJ B S,LU H,HUNG C F,et al.Determination of carotenoids and their esters in fruits of
Lycium barbarum Linnaeus by HPLC-DAD-APCI-MS[J].Journal of Pharmaceutical and Biomedical Analysis,2008,47(4/5):812-818.
[9] WEBER D,GRUNE T.The contribution of β-carotene to vitamin A supply of humans[J].Molecular Nutrition & Food Research,2012,56(2):251-258.

[10] DONHOWE E G,KONG F.Beta-carotene:digestion,microencapsulation,and
in vitro bioavailability[J].Food and Bioprocess Technology,2014,7(2):338-354.

[11] 陈波,江祖旭,刘清,等.不同来源的类胡萝卜素在鸡体组织中的沉积[J].中国家禽,1997(11):7-8.
[12] YANG A,LARSEN T W,TUME R K.Carotenoid and retinol concentrations in serum,adipose tissue and liver and carotenoid transport in sheep,goats and cattle[J].Australian Journal of Agricultural Research,1992,43(8):1809-1817.

[13] YONEKURA L,NAGAO A.Intestinal absorption of dietary carotenoids[J].Molecular Nutrition & Food Research,2007,51(1):107-115.

[14] FIERCE Y,DE MORAIS VIEIRA M,PIANTEDOSI R,et al.
In vitro and
in vivo characterization of retinoid synthesis from β-carotene[J].Archives of Biochemistry and Biophysics,2008,472(2):126-138.

[15] HERR F M,WARDLAW S A,KAKKAD B,et al.Intestinal vitamin A metabolism:coordinate distribution of enzymes and CRBP (Ⅱ)[J].Journal of Lipid Research,1993,34(9):1545-1554.
[16] IQBAL J,HUSSAIN M M.Intestinal lipid absorption[J].American Journal of Physiology.Endocrinology and Metabolism,2009,296(6):E1183-E1194.
[17] SHMARAKOV I O,YUEN J J,BLANER W S.Carotenoid metabolism and enzymology[M]//TANUMIHARDJO S A.Carotenoids and human health.Nutrition and health.New York:Humana Press,2013:29-56.
[18] REBOUL E,ABOU L,MIKAIL C,et al.Lutein transport by Caco-2 TC-7 cells occurs partly by a facilitated process involving the scavenger receptor class B typeⅠ (SR-BⅠ)[J].The Biochemical Journal,2005,387(Pt 2):455-461.
[19] MOUSSA M,LANDRIER J F,REBOUL E,et al.Lycopene absorption in human intestinal cells and in mice involves scavenger receptor class B type Ⅰ but not Niemann-Pick C1-like 1[J].The Journal of Nutrition,2008,138(8):1432-1436.
[20] NICOLLE C,CARDINAULT N,APRIKIAN O,et al.Effect of carrot intake on cholesterol metabolism and on antioxidant status in cholesterol-fed rat[J].European Journal of Nutrition,2003,42(5):254-261.

[21] RICHELLE M,ENSLEN M,HAGER C,et al.Both free and esterified plant sterols reduce cholesterol absorption and the bioavailability of β-carotene and α-tocopherol in normocholesterolemic humans[J].The American Journal of Clinical Nutrition,2004,80(1):171-177.
[22] DROVER V A,AJMAL M,NASSIR F,et al.CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood[J].The Journal of Clinical Investigation,2005,115(5):1290-1297.

[23] DROVER V A,NGUYEN D V,BASTIE C C,et al.CD36 mediates both cellular uptake of very long chain fatty acids and their intestinal absorption in mice[J].The Journal of Biological Chemistry,2008,283(19):13108-13115.

[24] O'DRISCOLL C M.Anatomy and physiology of the lymphatics[M]//CHARMAN W N,STELLA V J.Lymphatic transport of drugs.Boca Raton,FL:CRC Press,1992:1-35.
[25] CLEVIDENCE B A,BIERI J G.Association of carotenoids with human plasma lipoproteins[J].Methods in Enzymology,1993,214:33-46.
[26] KRINSKY N I,JOHNSON E J.Carotenoid actions and their relation to health and disease[J].Molecular Aspects of Medicine,2005,26(6):459-516.

[27] TYSSANDIER V,CHOUBERT G,GROLIER P,et al.Carotenoids,mostly the xanthophylls,exchange between plasma lipoproteins[J].International Journal for Vitamin and Nutrition Research,2002,72(5):300-308.

[28] BOREL P,MOUSSA M,REBOUL E,et al.Human plasma levels of vitamin E and carotenoids are associated with genetic polymorphisms in genes involved in lipid metabolism[J].The Journal of Nutrition,2007,137(12):2653-2659.
[29] BOREL P,MOUSSA M,REBOUL E,et al.Human fasting plasma concentrations of vitamin E and carotenoids,and their association with genetic variants in apo C-Ⅲ,cholesteryl ester transfer protein,hepatic lipase,intestinal fatty acid binding protein and microsomal triacylglycerol transfer protein[J].British Journal of Nutrition,2009,101(5):680-687.

[30] AMENGUAL J,LOBO G P,GOLCZAK M,et al.A mitochondrial enzyme degrades carotenoids and protects against oxidative stress[J].The FASEB Journal,2011,25(3):948-959.

[31] LEUENBERGER M G,ENGELOCH-JARRET C,WOGGON W D.The reaction mechanism of the enzyme-catalyzed central cleavage of β-carotene to retinal[J].Angewandte Chemie International Edition,2001,40(14):2613-2617.

[32] KLOER D P,SCHULZ G E.Structural and biological aspects of carotenoid cleavage[J].Cellular and Molecular Life Sciences,2006,63(19/20):2291-2303.
[33] LINDQVIST A,ANDERSSON S.Biochemical properties of purified recombinant human beta-carotene 15,15'-monooxygenase[J].The Journal of Biological Chemistry,2002,277(26):23942-23948.

[34] MORALES A,ROSAS A,GONZÁLEZ A,et al.Cloning of the bovine β-carotene-15,15'oxygenase and expression in gonadal tissues[J].International Journal for Vitamin and Nutrition Research,2006,76(1):9-17.

[35] NAGAO A,DURING A,HOSHINO C,et al.Stoichiometric conversion of all trans-β-carotene to retinal by pig intestinal extract[J].Archives of Biochemistry and Biophysics,1996,328(1):57-63.

[36] BARUA A B,OLSON J A.β-carotene is converted primarily to retinoids in rats in vivo[J].The Journal of Nutrition,2000,130(8):1996-2001.
[37] WYSS A.Carotene oxygenases:a new family of double bond cleavage enzymes[J].The Journal of Nutrition,2004,134(1):246S-250S.
[38] VON LINTIG J,VOGT K.Filling the gap in vitamin A research.Molecular identification of an enzyme cleaving beta-carotene to retinal[J].The Journal of Biological Chemistry,2000,275(16):11915-11920.

[39] LAMPERT J M,HOLZSCHUH J,HESSEL S,et al.Provitamin A conversion to retinal via the β,β-carotene-15,15'-oxygenase (
bcox) is essential for pattern formation and differentiation during zebrafish embryogenesis[J].Development,2003,130(10):2173-2186.

[40] BIEHLMAIER O,LAMPERT J M,VON LINTIG J,et al.Photoreceptor morphology is severely affected in the β,β-carotene-15,15'-oxygenase (
bcox) zebrafish morphant[J].European Journal of Neuroscience,2005,21(1):59-68.

[41] KIM Y S,KIM N H,YEOM S J,et al.
In vitro characterization of a recombinant Blh protein from an uncultured marine bacterium as a beta-carotene 15,15'-dioxygenase[J].The Journal of Biological Chemistry,2009,284(23):15781-15793.

[42] YAN W,JANG G F,HAESELEER F,et al.Cloning and characterization of a human beta,beta-carotene-15,15'-dioxygenase that is highly expressed in the retinal pigment epithelium[J].Genomics,2001,72(2):193-202.

[43] VON LINTIG J.Colors with functions:elucidating the biochemical and molecular basis of carotenoid metabolism[J].Annual Review of Nutrition,2010,30:35-56.
[44] DURING A,NAGAO A,HOSHINO C,et al.Assay of β-carotene 15,15'-dioxygenase activity by reverse-phase high-pressure liquid chromatography[J].Analytical Biochemistry,1996,241(2):199-205.

[45] SEINO Y,MIKI T,KIYONARI H,et al.ISX participates in the maintenance of vitamin A metabolism by regulation of beta-carotene 15,15'-monooxygenase (
Bcmo1) expression[J].The Journal of Biological Chemistry,2008,283(8):4905-4911.

[46] LOBO G P,HESSEL S,EICHINGER A,et al.ISX is a retinoic acid-sensitive gatekeeper that controls intestinal β,β-carotene absorption and vitamin A production[J].The FASEB Journal,2010,24(6):1656-1666.

[47] LIETZ G,LANGE J,RIMBACH G.Molecular and dietary regulation of β,β-carotene 15,15'-monooxygenase 1 (BCMO1)[J].Archives of Biochemistry and Biophysics,2010,502(1):8-16.

[48] SCHERZINGER D,AL-BABILI S.
In vitro characterization of a carotenoid cleavage dioxygenase from
Nostoc sp.PCC 7120 reveals a novel cleavage pattern,cytosolic localization and induction by highlight[J].Molecular Microbiology,2008,69(1):231-244.

[49] KIEFER C,HESSEL S,LAMPERT J M,et al.Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A[J].The Journal of Biological Chemistry,2001,276(17):14110-14116.
[50] POLIAKOV E,GENTLEMAN S,CHANDER P,et al.Biochemical evidence for the tyrosine involvement in cationic intermediate stabilization in mouse β-carotene 15,15'-monooxygenase[J].BMC Biochemistry,2009,10:31.
[51] LINDQVIST A,HE Y G,ANDERSSON S.Cell type-specific expression of β-carotene 9',10'-monooxygenase in human tissues[J].Journal of Histochemistry & Cytochemistry,2005,53(11):1403-1412.

[52] HU K Q,LIU C,ERNST H,et al.The biochemical characterization of ferret carotene-9',10'-monooxygenase catalyzing cleavage of carotenoids
in vitro and
in vivo[J].The Journal of Biological Chemistry,2006,281(28):19327-19338.

[53] MEIN J R,DOLNIKOWSKI G G,ERNST H,et al.Enzymatic formation of apo-carotenoids from the xanthophyll carotenoids lutein,zeaxanthin and β-cryptoxanthin by ferret carotene-9',10'-monooxygenase[J].Archives of Biochemistry and Biophysics,2011,506(1):109-121.

[54] LUVIZOTTO R A M,NASCIMENTO A F,VEERAMACHANENI S,et al.Chronic alcohol intake upregulates hepatic expression of carotenoid cleavage enzymes and
PPAR in rats[J].The Journal of Nutrition,2010,140(10):1808-1814.

[55] ZIOUZENKOVA O,ORASANU G,SHARLACH M,et al.Retinaldehyde represses adipogenesis and diet-induced obesity[J].Nature Medicine,2007,13(6):695-702.

[56] ANTHONY T D.Fat soluble vitamins,their biochemistry and application[M].Trowbridge:Redwood Burn Ltd.,1985:1-61.
[57] BIARD C,HARDY C,MOTREUIL S,et al.Dynamics of PHA-induced immune response and plasma carotenoids in birds:should we have a closer look?[J].The Journal of Experimental Biology,2009,212(9):1336-1343.

[58] OLSON J A.Molecular actions of carotenoids[M]//CANFIELD L M.Carotenoids in human health.New York:Academy of Sciences,1993:156-166.
[59] 陈波.不同来源的类胡萝卜素在动物机体内的沉积[J].中国家禽,1997(11):7-8.
[60] 马爱国.抗氧化营养素对DNA损伤的保护作用[J].青岛医学院学报,1996,32(2):95-97.
[61] KRINSKY N I.Effects of carotenoids in cellular and animal systems[J].The American Journal of Clinical Nutrition,1991,53(1):238S-246S.
[62] 阳冠明,孙胜涛,李树全,等.β-胡萝卜素对阿霉素致大鼠心肌组织的超氧化物歧化酶、谷胱甘肽过氧化物酶mRNA表达改变的影响[J].中国药理学通报,2006,22(4):465-470.
[63] ZHANG P,OMAYE S T.Antioxidant and prooxidant roles for β-carotene,α-tocopherol and ascorbic acid in human lung cells[J].Toxicology
in Vitro,2001,15(1):13-24.

[64] 胡春艳,浦跃朴,尹立红,等.β-胡萝卜素对香烟烟气诱导脂质过氧化的交互作用[J].卫生研究,2004,33(2):144-146.
[65] 江志琴,朱心强.高剂量β-胡萝卜素对大量吸烟者肺癌的不利影响及其作用机制[J].国外医学:卫生学分册,2005,32(5):265-269.
[66] WANG J Y,LARSON L L,OWEN F G.Effect of beta-carotene supplementation on reproductive performance of dairy heifers[J].Theriogenology,1982,18(4):461-473.

[67] TALAVERA F,CHEW B P.Comparative role of retinol,retinoie acid and beta-carotene on progesterone secretion by pig corpus leteum
in vitro[J].Journal of Reproduction and Fertility,1988,82:611.
[68] AMAR E C,KIRON V,SATOH S,et al.Enhancement of innate immunity in rainbow trout (
Oncorhynchus mykiss Walbaum) associated with dietary intake of carotenoids from natural products[J].Fish & Shellfish Immunology,2004,16(4):527-537.

[69] CHEW B P,PARK J S.Carotenoid action on the immune response[J].The Journal of Nutrition,2004,134(1):257S-261S.
[70] KOUTSOS E A,GARCÍA LÓPEZ J C,KLASING K C.Carotenoids from
in ovo or dietary sources blunt systemic indices of the inflammatory response in growing chicks (
Gallus gallus domesticus)[J].The Journal of Nutrition,2006,136(4):1027-1031.
[71] GARCIA A L,RÜHL R,HERZ U,et al.Retinoid- and carotenoid-enriched diets influence the ontogenesis of the immune system in mice[J].Immunology,2003,110(2):180-187.

[72] MCDEVITT T M,TCHAO R,HARRISON E H,et al.Carotenoids normally present in serum inhibit proliferation and induce differentiation of a human monocyte/macrophage cell line (U937)[J].The Journal of Nutrition,2005,135(2):160-164.
[73] 周利梅,周光宏.类胡萝卜素在动物营养中的研究进展[J].粮食与饲料工业,2001(2):39-41.
[74] SCHWARTZ J L,SINGH R P,TEICHER B,et al.Induction of a 70kD protein associated with the selective cytotoxicity of beta-carotene in human epidermal carcinoma[J].Biochemical and Biophysical Research Communications,1990,169(3):941-946.

[75] STIVALA L A,SAVIO M,QUARTA S,et al.The antiproliferative effect of β-carotene requires p21
waf1/cip1 in normal human fibroblasts[J].European Journal of Biochemistry,2000,267(8):2290-2296.

[76] MUTO Y,FUJII J,SHIDOJI Y,et al.Growth retardation in human cervical dysplasia-derived cell lines by β-carotene through down-regulation of epidermal growth factor receptor[J].The American Journal of Clinical Nutrition,1995,62(Suppl.6):1535S-1540S.
[77] PALOZZA P,SERINI S,MAGGIANO N,et al.Induction of cell cycle arrest and apoptosis in human colon adenocarcinoma cell lines by β-carotene through down-regulation of cyclin A and Bcl-2 family proteins[J].Carcinogenesis,2002,23(1):11-18.

[78] PALOZZA P,SERINI S,TORSELLO A,et al.Regulation of cell cycle progression and apoptosis by β-carotene in undifferentiated and differentiated HL-60 leukemia cells:possible involvement of a redox mechanism[J].International Journal of Cancer,2002,97(5):593-600.

[79] NIERENBERG D W,STUKEL T A,BARON J A,et al.Determinants of increase in plasma concentration of beta-carotene after chronic oral supplementation[J].The American Journal of Clinical Nutrition,1991,53(6):1443-1449.
[80] PRINCE M R,FRISOLI J K.Beta-carotene accumulation in serum and skin[J].The American Journal of Clinical Nutrition,1993,57(2):175-181.