综述 Review

2种胡萝卜素加氧酶相关特性及调控机制的研究进展

  • 肖寒 ,
  • 靳青 ,
  • 刘桂芬 ,
  • 万发春 ,
  • 刘晓牧
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  • 1. 山东省畜禽疫病防治与繁育重点实验室, 济南 250100;
    2. 山东省农业科学院畜牧兽医研究所, 济南 250100

收稿日期: 2014-06-18

  网络出版日期: 2014-12-05

基金资助

国家自然科学基金(31172232);山东省优秀中青年科学家科研奖励基金(BS2011SW043);现代农业(肉牛牦牛)产业技术体系建设专项资金(CARS-38)

Research Advances in the Relevant Features and Regulation Mechanisms of Two Kinds of β-Carotene Oxygenases

  • XIAO Han ,
  • JIN Qing ,
  • LIU Guifen ,
  • WAN Fachun ,
  • LIU Xiaomu
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  • 1. Shandong Key Lab of Animal Disease Control and Breeding, Jinan 250100, China;
    2. Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, China

Received date: 2014-06-18

  Online published: 2014-12-05

摘要

β-胡萝卜素在生物体内分布广泛,并具有重要的生物学功能.在脊椎动物中,2种类胡萝卜素裂解酶,即β-胡萝卜素-15,15'-加氧酶(BCMO1)和β-胡萝卜素-9',10'-双加氧脱氢酶(BCDO2)在其代谢过程中起到重要作用.BCMO1是β-胡萝卜素转化为维生素A的关键酶,与胚胎形成、脂类代谢也息息相关.BCDO2在维生素A转化中的作用被长期争论,但对类胡萝卜素可能诱发的线粒体功能紊乱起到保护作用.本文综述了这2种加氧酶在合成β-胡萝卜素中的作用,以及它们的底物特异性、组织特异性、主要调控因素和单核苷酸多态性,为进一步的应用研究奠定基础.

本文引用格式

肖寒 , 靳青 , 刘桂芬 , 万发春 , 刘晓牧 . 2种胡萝卜素加氧酶相关特性及调控机制的研究进展[J]. 动物营养学报, 2014 , 26(12) : 3587 -3592 . DOI: 10.3969/j.issn.1006-267x.2014.12.006

Abstract

β-carotene, which widely distributes in organisms, plays important biological functions. In vertebrates, two kinds of carotenoid oxygenases, i.e. β-carotene 15, 15'-momoxygenase 1 (BCMO1) and β-carotene-9', 10'-dioxygenase (BCDO2), are involved in numerous metabolism processes. As the key enzyme in the conversion from β-carotene to vitamin A,BCMO1 is related closely to embryo formation and lipid metabolism. Although the role of BCDO2 in the formation of vitamin A is still uncertain, there are some indications that it plays an important role in protection against mitochondria dysfunction induced by carotene. This paper summarized the roles of the two kinds of oxygenases in the synthesis of β-carotene, substrate specificities, tissue specificities, the main control factors and single-nucleotide polymorphism of the two oxygenases,which would be helpful for further related researches.

Key words: β-carotene; BCMO1; BCDO2

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