综述 Review

miR-21:生成、表达调控及对其细胞凋亡的影响

  • 彭涵 ,
  • 齐仁立 ,
  • 黄金秀 ,
  • 陈英 ,
  • 刘炎 ,
  • 刘作华
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  • 1. 西南大学荣昌校区, 荣昌 402460;
    2. 重庆市畜牧科学院, 荣昌 402460

收稿日期: 2014-06-23

  网络出版日期: 2014-12-05

基金资助

国家自然科学基金(31302055);重庆市畜牧科学院基本科研业务费(13426);重庆市自然科学基金重点项目(2011BA1033)

miR-21: Biogenesis, Expression Regulations and Its Role in Regulating Apoptosis

  • PENG Han ,
  • QI Renli ,
  • HUANG Jinxiu ,
  • CHEN Ying ,
  • LIU Yan ,
  • LIU Zuohua
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  • 1. Southwest University, Rongchang Campus, Rongchang 402460, China;
    2. Chongqing Academy of Animal Sciences, Rongchang 402460, China

Received date: 2014-06-23

  Online published: 2014-12-05

摘要

凋亡是细胞的一种基本生物学现象,在机体生命过程中发挥着重要作用.miRNAs是在真核生物内发现的一类长度约22个核苷酸的内源性非编码单链小RNA,通过调控靶基因的表达参与调控细胞的凋亡、分化、增殖、侵袭和代谢.大量的研究表明,miR-21作为miRNAs重要成员之一,与细胞凋亡有重要联系.本文将从miR-21的生成、表达调控及对细胞凋亡的影响方面进行综述.

本文引用格式

彭涵 , 齐仁立 , 黄金秀 , 陈英 , 刘炎 , 刘作华 . miR-21:生成、表达调控及对其细胞凋亡的影响[J]. 动物营养学报, 2014 , 26(12) : 3593 -3598 . DOI: 10.3969/j.issn.1006-267x.2014.12.007

Abstract

Apoptosis is a basic biological phenomenon, which plays a key role in physiological and pathological process. miRNAs are a small class of endogenous non-coding, single-stranded RNA of about 22 nucleotides in length, which are found in eukaryotes, and can regulate cell apoptosis, differentiation, proliferation, invasion and metabolism via regulating expression of target gene. Particularly, as one of miRNAs, miR-21 and its function in regulating cell apoptosis has been reported in extensive studies. This paper reviewed the biogenesis and expression regulations of miR-21and its role in regulating apoptosis.

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