[1] HENNESSY E,O'DRISCOLL L.Molecular medicine of microRNAs: structure,function and implications for diabetes[J].Expert Reviews in Molecular Medicine,2008,10:e24.
[2] LAU N C,LIM L P,WEINSTEIN E G,et al.An abundant class of tiny RNAs with probable regulatory roles in
Caenorhabditis elegans[J].Science,2001,294(5543):858-862.

[3] FABIAN M R,SONENBERG N,FILIPOWICZ W.Regulation of mRNA translation and stability by microRNAs[J].Annual Review of Biochemistry,2010,79(1):351-379.

[4] CARTHEW R W,SONTHEIMER E J.Origins and mechanisms of miRNAs and siRNAs[J].Cell,2009,136(4):642-655.

[5] BARTEL D P.MicroRNAs:genomics,biogenesis,mechanism,and function[J].Cell,2004,116(2):281-297.

[6] RIGOUTSOS I.New tricks for animal microRNAS:targeting of amino acid coding regions at conserved and nonconserved sites[J].Cancer Research,2009,69(8):3245-3248.

[7] SIOMI H,SIOMI M C.Posttranscriptional regulation of microRNA biogenesis in animals[J].Molecular Cell,2010,38(3):323-332.

[8] STAREGA-ROSLAN J,KOSCIANSKA E,KOZLOWSKI P,et al.The role of the precursor structure in the biogenesis of microRNA[J].Cellular and Molecular Life Sciences,2011,68(17):2859-2871.

[9] OKADA C,YAMASHITA E,LEE S J,et al.A high-resolution structure of the pre-microRNA nuclear export machinery[J].Science,2009,326(5957):1275-1279.

[10] KIM V N.MicroRNA biogenesis:coordinated cropping and dicing[J].Nature Reviews:Molecular Cell Biology,2005,6(5):376-385.

[11] FARAZI T A,HOELL J I,MOROZOV P,et al.MicroRNAs in human cancer[J].The Journal of Pathology,2011,223(2):102-115.

[12] CHENG Y H,ZHANG C X.MicroRNA-21 in cardiovascular disease[J].Journal of Cardiovascular Translational Research,2010,3(3):251-255.

[13] HUANG Y,YANG Y B,ZHANG X H,et al.MicroRNA-21 gene and cancer[J].Medical Oncology,2013,30(1):376.
[14] JAZBUTYTE V,THUM T.MicroRNA-21:from cancer to cardiovascular disease[J].Current Drug Targets,2010,11(8):926-935.

[15] Stem-loop sequence hsa-miR-21[DB/OL].Mirbase[2014-5-20].http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000077.
[16] KUMARSWAMY R,VOLKMANN I,THUM T.Regulation and function of miRNA-21 in health and disease[J].RNA Biology,2011,8(5):706-713.

[17] CAI X Z,HAGEDORN C H,CULLEN B R.Human microRNAs are processed from capped,polyadenylated transcripts that can also function as mRNAs[J].RNA,2004,10(12):1957-1966.

[18] LÖFFLER D,BROCKE-HEIDRICH K,PFEIFER G,et al.Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer[J].Blood,2007,110(4):1330-1333.

[19] FUJITA S,ITO T,MIZUTANI T,et al.
miR-21 gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism[J].Journal of Molecular Biology,2008,378(3):492-504.

[20] KRICHEVSKY A M,GABRIELY G.miR-21:a small multi-faceted RNA[J].Journal of Cellular and Molecular Medicine,2009,13(1):39-53.
[21] WICKRAMASINGHE N S,MANAVALAN T T,DOUGHERTY S M,et al.Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells[J].Nucleic Acids Research,2009,37(8):2584-2595.

[22] RIBAS J,NI X H,HAFFNER M,et al.miR-21:An androgen receptor-regulated microRNA that promotes hormone-dependent and hormone-independent prostate cancer growth[J].Cancer Research,2009,69(18):7165-7169.

[23] RIBAS J,LUPOLD S E.The transcriptional regulation of miR-21,its multiple transcripts and their implication in prostate cancer[J].Cell Cycle,2010,9(5):923-929.

[24] CHIOSEA S,JELEZCOVA E,CHANDRAN U,et al.Up-regulation of dicer,a component of the MicroRNA machinery,in prostate adenocarcinoma[J].The American Journal of Pathology,2006,169(5):1812-1820.

[25] AMBS S,PRUEITT R L,YI M,et al.Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer[J].Cancer Research,2008,68(15):6162-6170.

[26] WANG Z G.MicroRNA:a matter of life or death[J].World Journal of Biological Chemistry,2010,1(4):41-54.

[27] CHAN J A,KRICHEVSKY A M,KOSIK K S.MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells[J].Cancer Research,2005,65(14):6029-6033.

[28] CORSTEN M F,MIRANDA R,KASMIEH R,et al.MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell-delivered S-TRAIL in human gliomas[J].Cancer Research,2007,67(19):8994-9000.

[29] CHEN Y,LIU W,CHAO T F,et al.MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G[J].Cancer Letters,2008,272(2):197-205.

[30] PAPAGIANNAKOPOULOS T,SHAPIRO A,KOSIK K S.MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells[J].Cancer Research,2008,68(19):8164-8172.

[31] SI M L,ZHU S,WU H,et al.miR-21-mediated tumor growth[J].Oncogene,2007,26(19):2799-2803.

[32] YIN C,WANG X Y,KUKREJA R C.Endogenous microRNAs induced by heat-shock reduce myocardial infarction following ischemia-reperfusion in mice[J].FEBS Letters,2008,582(30):4137-4142.

[33] CHENG Y H,LIU X J,ZHANG S,et al.MicroRNA-21 protects against the H
2O
2-induced injury on cardiac myocytes via its target gene
PDCD4[J].Journal of Molecular and Cellular Cardiology,2009,47(1):5-14.

[34] JI R,CHENG Y,YUE J,et al.MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation[J].Circulation Research,2007,100(11):1579-1588.

[35] 赵艳丽,姜怀志,张世伟,等.辽宁绒山羊皮肤毛囊细胞凋亡特点的研究[J].中国畜牧兽医,2011,38(8):35-38.
[36] 黄小丹,孙斌,李广兴.兔乳腺上皮细胞凋亡与泌乳量的相关性研究[J].繁殖生理,2012,48(11):28-30.
[37] 李惠侠,王振云,张震,等.高温条件下miRNA-24对奶牛乳腺上皮细胞增殖与凋亡的影响[J].中国农业科学,2010,43(22):4732-4738.
[38] 于太永,庞卫军,吴江维,等.TNF-α通过ERK和MAPK信号途径抑制猪骨骼肌成肌细胞分化[J].动物学报,2007,53(5):877-883.
[39] 刘忠华,刘海兰,岳奎忠,等.性未成熟小母猪注射PMSG对卵泡闭锁及颗粒细胞凋亡的影响[J].中国兽医学报,2002,7,22(4):384-386.