综述 Review

细菌在氨基酸首过肠道代谢中的作用

  • 杨宇翔 ,
  • 慕春龙 ,
  • 朱伟云
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  • 南京农业大学消化道微生物研究室, 南京 210095

收稿日期: 2014-07-29

  网络出版日期: 2015-01-10

基金资助

国家重点基础研究发展计划(973)(2013CB127300);江苏省自然科学基金(BK20130058);教育部高等学校博士点科研基金(20130097130005)

Roles of Bacteria in First-Pass Intestinal Metabolism of Amino Acids

  • YANG Yuxiang ,
  • MU Chunlong ,
  • ZHU Weiyun
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  • College of Animal Science and Technology, Nanjing Agricultural Uniersity, Nanjing 210095, China

Received date: 2014-07-29

  Online published: 2015-01-10

摘要

肠道细菌在营养素代谢过程中起重要作用,进而影响机体整体代谢。小肠是氨基酸代谢的重要场所,对宿主蛋白质营养与肠道健康至关重要。然而,大量进入小肠的氨基酸在首过肠道代谢中被细菌转化代谢和利用。此外,小肠细菌对氨基酸的代谢呈现出区室化特征,这不仅表现在不同肠段上,还体现在层面上的差异。细菌对氨基酸的代谢产物包括二肽、多胺,它们能影响宿主肠道健康,细菌分解尿素再合成氨基酸的功能可能在一定程度上缓解宿主对氨基酸的需求。本文主要综述了小肠细菌在氨基酸首过肠道代谢中的作用与去路、对氨基酸代谢的区室化以及氨基酸代谢产物对宿主的影响。

本文引用格式

杨宇翔 , 慕春龙 , 朱伟云 . 细菌在氨基酸首过肠道代谢中的作用[J]. 动物营养学报, 2015 , 27(1) : 15 -20 . DOI: 10.3969/j.issn.1006-267x.2015.01.003

Abstract

Intestinal bacteria play important roles in nutrient metabolism, which furtherly affect body metabolism. Small intestine is the main region for amnio acids metabolism, and is critical to the host protein nutrition and gut health. However, large amount of amino acids entered into small intestine was degraded during the first-pass intestinal metabolism by bacteria. Amino acid metabolism in the small intestine is compartmentalized, not only segmented, but also layered. Amino acid metabolites, such as polyamine and dipeptide, are important for host gut health. Moreover, urea degradation and subsequent amino acid synthesis by the bacteria might be nutritionally valuable for the host. This article mainly reviewed the roles and out-ways in the first-pass intestinal metabolism of amino acids, metabolic compartments of amino acids, and the impacts of the metabolites on host health of small intestinal bacteria.

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