综述 Review

硒对奶牛乳腺炎的调节作用及抗炎机制

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  • 1. 东北林业大学野生动物资源学院动物医学系, 哈尔滨 150040;
    2. 吉林大学动物医学学院, 长春 130062
张雯(1984-),女,吉林吉林人,讲师,博士,主要从事野生动物产科病和临床免疫学研究。E-mail:zhangwenwakeup@126.com

收稿日期: 2014-11-14

  网络出版日期: 2015-04-21

基金资助

国家自然科学基金(31272622);中央高校基本科研业务费专项(2572015BAX01)

Regulation and Anti-Inflammatory Mechanisms of Selenium for Bovine Mastitis

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  • 1. College of Wildlife Resources, Northeast Forestry University, Harbin 150040, China;
    2. College of Veterinary Medicine, Jilin University, Changchun 130062, China

Received date: 2014-11-14

  Online published: 2015-04-21

摘要

奶牛乳腺炎在临产和泌乳期奶牛中发病率较高,严重影响乳腺健康和牛奶生产,对世界范围内的奶牛业造成重大经济损失。微量元素硒可降低奶牛乳腺炎的发病率和严重程度。本文从硒与奶牛乳腺炎的关系、硒在炎症中对先天性免疫和获得性免疫的调节作用以及硒对炎症相关信号转导机制的调控等几个方面进行了综述,为通过饲粮补硒以改善奶牛乳腺健康提供理论支持。

本文引用格式

张雯, 张乃生 . 硒对奶牛乳腺炎的调节作用及抗炎机制[J]. 动物营养学报, 2015 , 27(4) : 1021 -1027 . DOI: 10.3969/j.issn.1006-267x.2015.04.003

Abstract

Bovine mastitis has a high morbidity during the periparturient and lactation period. As a result, mammary gland health and milk performance are affected, thereby causing worldwide economic losses. The trace element selenium (Se) reduces the morbidity and the severity of mastitis. This article provided an overview of the most recent researches in the fields of the relationship between the Se and bovine mastitis, the regulation of Se in the innate and adaptive immunity, and the regulation of Se on inflammatory response associated signaling pathways. The better understanding on the mechanisms of anti-inflammatory effects of Se can help during the improvement of mammary health of dairy cows.

参考文献

[1] SALMAN S, KHOL-PARISINI A, SCHAFFT H, et al.The role of dietary selenium in bovine mammary gland health and immune function[J].Animal Health Research Review, 2009, 10(1):21-34.  

[2] DUNTAS L H.Selenium and inflammation:underlying anti-inflammatory mechanisms[J].Hormone and Metabolic Research, 2009, 41(6):443-447.  

[3] KOHRLE J.Selenium and the thyroid[J].Current Opinion in Endocrinology, Diabetes and Obesity, 2013, 20(5):441-448.  

[4] BOURNE N, WATHES D C, LAWRENCE K E, et al.The effect of parenteral supplementation of vitamin E with selenium on the health and productivity of dairy cattle in the UK[J].The Veterinary Journal, 2008, 177(3):381-387.  

[5] SMITH K L, HARRISON J H, HANCOCK D D, et al.Effect of vitamin E and selenium supplementation on incidence of clinical mastitis and duration of clinical symptoms[J].Journal of Dairy Science, 1984, 67(6):1293-1300.  

[6] ERSKINE R J, EBERHART R J, HUTCHINSON L J, et al.Blood selenium concentrations and glutathione peroxidase activities in dairy herds with high and low somatic cell counts[J].Journal of American Veterinary Medicine Association, 1987, 190(11):1417-1421.

[7] WEISS W P, HOGAN J S, SMITH K L, et al.Relationships among selenium, vitamin E, and mammary gland health in commercial dairy herds[J].Journal of Dairy Science, 1990, 73(2):381-390.  

[8] 周文彬, 佘鹏湘, 缪建祖, 等.硒和维生素E对奶牛胎衣滞留乳腺炎及受胎率的影响[J].中国兽医科技, 1993, 23(1):30-31.

[9] CEBALLOS-MARQUEZ A, BARKEMA H W, STRYHN H, et al.The effect of selenium supplementation before calving on early-lactation udder health in pastured dairy heifers[J].Journal of Dairy Science, 2010, 93(10):4602-4612.  

[10] CEBALLOS A, KRUZE J, BARKEMA H W, et al.Barium selenate supplementation and its effect on intramammary infection in pasture-based dairy cows[J].Journal of Dairy Science, 2010, 93(4):1468-1477.  

[11] 张克春, 徐国忠, 吴显实, 等.日粮添加富硒益生菌对奶牛乳房炎和乳汁体细胞数的影响[J].上海交通大学学报:农业科学版, 2010, 28(1):59-63.

[12] SHIBATA Y, MORITA M, FUWA K.Selenium and arsenic in biology:their chemical forms and biological functions[J].Advances in Biophysics, 1992, 28:31-80.

[13] SPEARS J W, WEISS W P.Role of antioxidants and trace elements in health and immunity of transition dairy cows[J].The Veterinary Journal, 2008, 176(1):70-76.  

[14] MCDOUGALL S, PARKER K I, WEIR A M, et al.Effect of application of an external teat sealant and/or oral treatment with a monensin capsule pre-calving on the prevalence and incidence of subclinical and clinical mastitis in dairy heifers[J].New Zealand Veterinary Journal, 2008, 56(3):120-129.  

[15] SORDILLO L M, AITKEN S L.Impact of oxidative stress on the health and immune function of dairy cattle[J].Veterinary Immunology and Immunopathology, 2009, 128(1/2/3):104-109.

[16] SORDILLO L M.Selenium-dependent regulation of oxidative stress and immunity in periparturient dairy cattle[J].Veterinary Medicine International, 2013, 2013:154045.

[17] ERSKINE R J, EBERHART R J, GRASSO P J, et al.Induction of Escherichia coli mastitis in cows fed selenium-deficient or selenium-supplemented diets[J].American Journal of Veterinary Research, 1989, 50(12):2093-2100.

[18] CONTRERAS G A, RODRIGUEZ J M.Mastitis:comparative etiology and epidemiology[J].Journal of Mammary Gland Biology and Neoplasia, 2011, 16(4):339-356.  

[19] WANG J, ZHANG Y, YUAN Y, et al.Immunomodulatory of selenium nano-particles decorated by sulfated Ganoderma lucidum polysaccharides[J].Food and Chemical Toxicology, 2014, 68:183-189.

[20] NDIWENI N, FINCH J M.Effects of in vitro supplementation of bovine mammary gland macrophages and peripheral blood lymphocytes with alpha-tocopherol and sodium selenite:implications for udder defences[J].Veterinary Immunology and Immunopathology, 1995, 47(1/2):111-121.

[21] 弓剑, 闫素梅.硒对奶牛乳腺氧化应激与乳腺免疫功能的调节作用[J].动物营养学报, 2014, 26(3):557-564

[22] AITKEN S L, CORL C M, SORDILLO L M.Immunopathology of mastitis:insights into disease recognition and resolution.[J].Journal of Mammary Gland Biology and Neoplasia, 2011, 16(4):291-304.  

[23] WALSH D M, KENNEDY D G, GOODALL E A, et al.Antioxidant enzyme activity in the muscles of calves depleted of vitamin E or selenium or both[J].British Journal of Nutrition, 1993, 70(2):621-630.  

[24] CHEN K J, YUAN S B, CHEN J, et al.Effects of sodium selenite on the decreased percentage of T cell subsets, contents of serum IL-2 and IFN-γ induced by aflatoxin B1 in broilers[J].Research in Veterinary Science, 2013, 95(1):143-145.  

[25] GURJAR A A, KLAESSIG S, SALMON S A, et al.Evaluation of an alternative dosing regimen of a J-5 mastitis vaccine against intramammary Escherichia coli challenge in nonlactating late-gestation dairy cows[J].Journal of Dairy Science, 2013, 96(8):5053-5063.  

[26] CAO Y Z, REDDY C C, SORDILLO L M.Altered eicosanoid biosynthesis in selenium-deficient endothelial cells[J].Free Radical Biology and Medicine, 2000, 28(3):381-389.  

[27] WEAVER J A, MADDOX J F, CAO Y Z, et al.Increased 15-HPETE production decreases prostacyclin synthase activity during oxidant stress in aortic endothelial cells[J].Free Radical Biology and Medicine, 2001, 30(3):299-308.  

[28] SORDILLO L M, WEAVER J A, CAO Y Z, et al.Enhanced 15-HPETE production during oxidant stress induces apoptosis of endothelial cells[J].Prostaglandins & Other Lipid Mediators, 2005, 76(1/2/3/4):19-34.

[29] ZHANG F, YU W, HARGROVE J L, et al.Inhibition of TNF-α induced ICAM-1, VCAM-1 and E-selectin expression by selenium[J].Atherosclerosis, 2002, 161(2):381-386.  

[30] D'AMICO T A, BROOKS K R, JOSHI M B M, et al.Serum protein expression predicts recurrence in patients with early-stage lung cancer after resection[J].The Annals of Thoracic Surgery, 2006, 81(6):1982-1987.  

[31] DIEZ-FRAILLE A, MEHRZAD J, MEYER E, et al.Comparison of L-selectin and Mac-1 expression on blood and milk neutrophils during experimental Escherichia coli-induced mastitis in cows[J].American Journal of Veterinary Research, 2004, 65(8):1164-1171.  

[32] NEWTON R, HOLDEN N S.New aspects of p38 mitogen activated protein kinase (MAPK) biology in lung inflammation[J].Drug Discovery Today:Disease Mechanisms, 2006, 3(1):53-61.  

[33] TORNATORE L, THOTAKURA A K, BENNETT J, et al.The nuclear factor kappa B signaling pathway:integrating metabolism with inflammation[J].Trends in Cell Biology, 2012, 22(11):557-566.  

[34] MC GUIRE C, PRINZ M, BEYAERT R, et al.Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology[J].Trends in Molecular Medicine, 2013, 19(10):604-613.  

[35] AN M J, CHEON J H, KIM S W, et al.Bovine colostrum inhibits nuclear factor κB-mediated proinflammatory cytokine expression in intestinal epithelial cells[J].Nutrition Research, 2009, 29(4):275-280.  

[36] CELEC P.Nuclear factor kappa B-molecular biomedicine:the next generation[J].Biomedicine & Pharmacotherapy, 2004, 58(6/7):365-371.

[37] ZAMAMIRI-DAVIS F, LU Y, THOMPSON J T, et al.Nuclear factor-κB mediates over-expression of cyclooxygenase-2 during activation of RAW 264.7 macrophages in selenium deficiency[J].Free Radical Biology and Medicine, 2002, 32(9):890-897.  

[38] KIM S H, JOHNSON V J, SHIN T Y, et al.Selenium attenuates lipopolysaccharide-induced oxidative stress responses through modulation of p38 MAPK and NF-kappaB signaling pathways[J].Experimental Biology and Medicine (Maywood), 2004, 229(2):203-213.

[39] KOYANI C N, WINDISCHHOFER W, ROSSMANN C, et al.15-deoxy-Δ12, 14-PGJ2 promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis[J].International Journal of Cardiology, 2014, 173(3):472-480.  

[40] LI D P, FU Y H, ZHANG W, et al.Salidroside attenuates inflammatory responses by suppressing nuclear factor-κB and mitogen activated protein kinases activation in lipopolysaccharide-induced mastitis in mice[J].Inflammation Research, 2013, 62(1):9-15.  

[41] ZHANG W, ZHANG R X, WANG T C, et al.Selenium inhibits LPS-induced pro-inflammatory gene expression by modulating MAPK and NF-κB signaling pathways in mouse mammary epithelial cells in primary culture[J].Inflammation, 2014, 37(2):478-485.  
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