综述 Review

腺苷酸活化蛋白激酶在哺乳动物卵巢发育中的调控作用及其机制

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  • 四川农业大学动物营养研究所, 雅安 625014
许蒙蒙(1988—),女,河南安阳人,硕士研究生,从事动物营养与饲料科学研究。E-mail:xumengmeng2013@126.com

收稿日期: 2015-04-28

  网络出版日期: 2015-10-15

基金资助

四川省教育厅重点项目(13ZA0259);四川农业大学引进人才科研启动项目;川猪遗传改良与安全生产教育部创新团队(IRT13083)

Regulation of Adenosine 5'-Monophosphate-Activated Protein Kinase in Mammalian Ovary Development and Mechanisms

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  • Animal Nutrition Institute, Sichuan Agricultural University, Ya'an 625014, China

Received date: 2015-04-28

  Online published: 2015-10-15

摘要

腺苷酸活化蛋白激酶(AMPK)信号通路作为调节细胞能量代谢状态的中心环节,是调控哺乳动物繁殖性能的关键因子。已有研究表明,AMPK在哺乳动物卵巢发育中主要通过介导葡萄糖、胰岛素样生长因子-1(IGF-1)、促卵泡素(FSH)、脂联素等发挥功能。本文就AMPK在哺乳动物卵巢发育中的调控作用及其机制进行综述,旨在引起人们对AMPK调控卵巢发育的关注,并为卵巢疾病的治疗提供一定参考。

关键词: AMPK; 卵巢; 葡萄糖; IGF-1; FSH; 脂联素

本文引用格式

许蒙蒙, 车龙, 张攀, 吴德, 徐盛玉 . 腺苷酸活化蛋白激酶在哺乳动物卵巢发育中的调控作用及其机制[J]. 动物营养学报, 2015 , 27(10) : 3006 -3011 . DOI: 10.3969/j.issn.1006-267x.2015.10.003

Abstract

Adenosine 5'-monophosphate-activated protein kinase (AMPK) regulation pathway is the central part of the cellular energy metabolism, which plays a vital role in the female reproductive tract development.Numerous studies have explored the relationship between AMPK and ovary development, and the role of AMPK mediates glucose, insulin-like growth factor-1 (IGF-1), follicle stimulating hormone (FSH) and adiponectin.In this paper, the advances in the regulation of AMPK in the mammalian ovary development were reviewed in order to promoting further the research on application of AMPK for cure of ovary disease.

Key words: AMPK; ovary; glucose; IGF-1; FSH; adiponectin

参考文献

[1] ADAMS G P,JAISWALR,SINGH J,et al.Progress in understanding ovarian follicular dynamics in cattle[J].Theriogenology,2008,69(1):72-80.  

[2] BUKOVSKY A.Novel methods of treating ovarian infertility in older and POF women,testicular infertility,and other human functional diseases[J].Reproductive Biology and Endocrinology,2015,13(1):10.

[3] MUKHERJEE A,ROY S K.Expression of ErbB3-binding protein-1 (EBP1) during primordial follicle formation:role of estradiol-17 [J].PLoS One,2013,8(6):e67068.

[4] ROLAND A V,MOENTER S M.Regulation of gonadotropin-releasing hormone neurons by glucose[J].Trends in Endocrinology & Metabolism,2011,22(11):443-449.  

[5] ZHOU D S,FANG Z F,WU D,et al.Dietary energy source and feeding levels during the rearing period affect ovarian follicular development and oocyte maturation in gilts[J].Theriogenology,2010,74(2):202-211.  

[6] VAN DEN BRAND H,DIELEMAN S J,SOEDE N M,et al.Dietary energy source at two feeding levels during lactation of primiparous sows:Ⅰ.Effects on glucose,insulin,and luteinizing hormone and on follicle development,weaning-to-estrus interval,and ovulation rate[J].Journal of Animal Science,2000,78(2):396-404.

[7] HARDIE D G.The AMP-activated protein kinase pathway-new players upstream and downstream[J].Journal of Cell Science,2004,117(23):5479-5487.  

[8] DUPONT J,REVERCHON M,BERTOLDO M J,et al.Nutritional signals and reproduction[J].Molecular and Cellular Endocrinology,2014,382(1):527-537.  

[9] DUPONT J,REVERCHON M,CLOIX L,et al.Involvement of adipokines,AMPK,PI3K and the PPAR signaling pathways in ovarian follicle development and cancer[J].The International Journal of Developmental Biology,2012,56(10/11/12):959-967.

[10] DOWNS S M,HUDSON E R,HARDIE D G.A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes[J].Developmental Biology,2002,245(1):200-212.  

[11] CHAPPAZ E,ALBORNOZ M S,CAMPOS D,et al.Adiponectin enhances in vitro development of swine embryos[J].Domestic Animal Endocrinology,2008,35(2):198-207.  

[12] GALLET C,DUPONT J,CAMPBELL B K,et al.The infusion of glucose in ewes during the luteal phase increases the number of follicles but reduces oestradiol production and some correlates of metabolic function in the large follicles[J].Animal Reproduction Science,2011,127(3/4):154-163.

[13] LEDOUX S,CAMPOS D B,LOPES F L,et al.Adiponectin induces periovulatory changes in ovarian follicular cells[J].Endocrinology,2006,147(11):5178-5186.  

[14] ROLAND A V,MOENTER S M.Glucosensing by GnRH neurons:inhibition by androgens and involvement of AMP-activated protein kinase[J].Molecular Endocrinology,2011,25(5):847-858.  

[15] RATCHFORD A M,CHANG A S,CHI M M Y,et al.Maternal diabetes adversely affects AMP-activated protein kinase activity and cellular metabolism in murine oocytes[J].American Journal of Physiology-Endocrinology and Metabolism,2007,293(5):E1198-E1206.

[16] PRIEBE A,TAN L J,WAHL H,et al.Glucose deprivation activates AMPK and induces cell death through modulation of Akt in ovarian cancer cells[J].Gynecologic Oncology,2011,122(2):389-395.  

[17] SALAZER-ORTIZ J,MONGET P,GUILLAUME D.The influence of nutrition on the insulin-like growth factor system and the concentrations of growth hormone,glucose,insulin,gonadotropins and progesterone in ovarian follicular fluid and plasma from adult female horses (Equus caballus)[J].Reproductive Biology and Endocrinology,2014,12(1):72.

[18] DOMINGUEZ L J,DAVIDOFF A J,SRINIVAS P R,et al.Effects of metformin on tyrosine kinase activity,glucose transport,and intracellular calcium in rat vascular smooth muscle[J].Endocrinology,1996,137(1):113-121.

[19] TOSCA L,CHABROLLE C,UZBEKOVA S,et al.Effects of metformin on bovine granulosa cells steroidogenesis:possible involvement of adenosine 5' monophosphate-activated protein kinase (AMPK)[J].Biology of Reproduction,2007,76(3):368-378.  

[20] SCARMUZZI R J,BROWN H M,DUPONT J.Nutritional and metabolic mechanisms in the ovary and their role in mediating the effects of diet on folliculogenesis:a perspective[J].Reproduction in Domestic Animals,2010,45(Suppl.3):32-41.

[21] TOSCA L,CHABROLLE C,CROCHET S,et al.IGF-1 receptor signaling pathways and effects of AMPK activation on IGF-1-induced progesterone secretion in hen granulosa cells[J].Domestic Animal Endocrinology,2008,34(2):204-216.  

[22] REVERCHON M,CORNUAU M,RAMÉ C,et al.Chemerin inhibits IGF-1-induced progesterone and estradiol secretion in human granulosa cells[J].Human Reproduction,2012,27(6):1790-1800.  

[23] KAYAMPILLY P P,MENON K M J.Follicle-stimulating hormone inhibits adenosine 5'-monophosphate-activated protein kinase activation and promotes cell proliferation of primary granulosa cells in culture through an Akt-dependent pathway[J].Endocrinology,2009,150(2):929-935.  

[24] KAYAMPILLY P P,MENON K M J.AMPK activation by dihydrotestosterone reduces FSH-stimulated cell proliferation in rat granulosa cells by inhibiting ERK signaling pathway[J].Endocrinology,2012,153(6):2831-2838.  

[25] WANG W,GUAN K L.AMP-activated protein kinase and cancer[J].Acta Physiologica,2009,196(1):55-63.  

[26] ORLIK B,MADEJ P,OWCZAREK A,et al.Plasma omentin and adiponectin levels as markers of adipose tissue dysfunction in normal weight and obese women with polycystic ovary syndrome[J].Clinical Endocrinology,2014,81(4):529-535.  

[27] SMOLINSKA N,DOBRZYN K,MALESZKA A,et al.Expression of adiponectin and adiponectin receptors 1 (AdipoR1) and 2 (AdipoR2) in the porcine uterus during the oestrous cycle[J].Animal Reproduction Science,2014,146(1/2):42-54.

[28] CHABROLLE C,TOSCA L,DUPONT J.Regulation of adiponectin and its receptors in rat ovary by human chorionic gonadotrophin treatment and potential involvement of adiponectin in granulosa cell steroidogenesis[J].Reproduction,2007,133(4):719-731.  

[29] LU M,TANG Q B,OLEFSKY J M,et al.Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LβT2 gonadotropes[J].Molecular Endocrinology,2008,22(3):760-771.  
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