[1] ZHU L Y,NIE L,ZHU G,et al.Advances in research of fish immune-relevant genes:a comparative overview of innate and adaptive immunity in teleosts[J].Developmental & Comparative Immunology,2013,39 (1/2):39-62.
[2] KIRON V.Fish immune system and its nutritional modulation for preventive health care[J].Animal Feed Science and Technology,2012,173(1/2):111-133.
[3] WEST N E J,QIAN H S,GUZIK T J,et al.Nitric oxide synthase (nNOS) gene transfer modifies venous bypass graft remodeling:effects on vascular smooth muscle cell differentiation and superoxide production[J].Circulation,2001,104(13):1526-1532.

[4] CHEN G F,LIU Y,JIANG J,et al.Effect of dietary arginine on the immune response and gene expression in head kidney and spleen following infection of Jian carp with
Aeromonas hydrophila[J].Fish & Shellfish Immunology,2015,44(1):195-202.

[5] COSTAS B,CONCEIÇÀO L E C,DIAS J,et al.Dietary arginine and repeated handling increase disease resistance and modulate innate immune mechanisms of Senegalese sole (
Solea senegalensis Kaup,1858)[J].Fish & Shellfish Immunology,2011,31(6):838-847.

[6] COSTAS B,GÊGO P C N P,CONCEIÇÀ L E C,et al.Dietary arginine supplementation decreases plasma cortisol levels and modulates immune mechanisms in chronically stressed turbot (
Scophthalmus maximus)[J].Aquaculture Nutrition,2013,19(Suppl.1):25-38.
[7] HOLEN E,ESPE M,ANDERSEN S M,et al.A co culture approach show that polyamine turnover is affected during inflammation in Atlantic salmon immune and liver cells and that arginine and LPS exerts opposite effects on p38MAPK signaling[J].Fish & Shellfish Immunology,2014,37(2):286-298.

[8] JIANG J,SHI D,ZHOU X Q,et al.
In vitro and
in vivo protective effect of arginine against lipopolysaccharide induced inflammatory response in the intestine of juvenile Jian carp (
Cyprinus carpio var.Jian)[J].Fish & Shellfish Immunology,2015,42(2):457-464.

[9] WANG B,FENG L,JIANG W D,et al.Copper-induced tight junction mRNA expression changes,apoptosis and antioxidant responses via NF-κB,TOR and Nrf2 signaling molecules in the gills of fish:preventive role of arginine[J].Aquatic toxicology,2015,158:125-137.
[10] ZHAO J,FENG L,LIU Y,et al.Effect of dietary isoleucine on the immunity,antioxidant status,tight junctions and microflora in the intestine of juvenile Jian carp (
Cyprinus carpio var.Jian)[J].Fish & Shellfish Immunology,2014,41(2):663-673.

[11] WEN H L,FENG L,JIANG W D,et al.Dietary tryptophan modulates intestinal immune response,barrier function,antioxidant status and gene expression of TOR and Nrf2 in young grass carp (
Ctenopharyngodon idella)[J].Fish & Shellfish Immunology,2014,40(1):275-287.

[12] LUSHCHAK V I.Environmentally induced oxidative stress in aquatic animals[J].Aquatic Toxicology,2011,101(1):13-30.

[13] WANG B,LIU Y,FENG L,et al.Effects of dietary arginine supplementation on growth performance,flesh quality,muscle antioxidant capacity and antioxidant-related signalling molecule expression in young grass carp (
Ctenopharyngodon idella)[J].Food Chemistry,2015,167:91-99.
[14] DELERIVE P,FRUCHART J C,STAELS B.Peroxisome proliferator-activated receptors in inflammation control[J].The Journal of Endocrinol,2001,169:453-459.
[15] NIKLASSON L.Intestinal mucosal immunology of salmonids response to stress and infection and crosstalk with the physical barrier[D].Ph.D.Thesis.Geoteborg:University of Gothenburg,2013.
[16] BEUTHEU S,GHOUZALI I,GALAS L,et al.Glutamine and arginine improve permeability and tight junction protein expression in methotrexate-treated Caco-2 cells[J].Clinical Nutrition,2013,32(5):863-869.

[17] FUJITA H,CHIBA H,YOKOZAKI H,et al.Differential expression and subcellular localization of Claudin-7,-8,-12,-13,and -15 along the mouse intestine[J].Journal of Histochemistry & Cytochemistry,2006,54(8):933-944.

[18] POHLENZ C,BUENTELLO A,MWANGI W,et al.Arginine and glutamine supplementation to culture media improves the performance of various channel catfish immune cells[J].Fish & Shellfish Immunology,2012,32(5):762-768.

[19] BUENTELLO J A,REYES-BECERRIL M,ROMERO-GERALDO M D J,et al.Effects of dietary arginine on hematological parameters and innate immune function of channel catfish[J].Journal of Aquatic Animal Health,2007,19(3):195-203.

[20] CHENG Z Y,BUENTELLO A,GATLIN D M Ⅲ.Effects of dietary arginine and glutamine on growth performance,immune responses and intestinal structure of red drum,
Sciaenops ocellatus[J].Aquaculture,2011,319(1/2):247-252.
[21] CHENG Z Y,GATLIN D M Ⅲ,BUENTELLO A.Dietary supplementation of arginine and/or glutamine influences growth performance,immune responses and intestinal morphology of hybrid striped bass (
Morone chrysops×Morone saxatilis)[J].Aquaculture,2012,362-363:39-43.
[22] WEYTS F A A,FLIK G,VERBURG-VAN KEMENADE B M L.Cortisol inhibits apoptosis in carp neutrophilic granulocytes[J].Developmental & Comparative Immunology,1998,22(5/6):563-572.
[23] REN W K,CHEN S,YIN J,et al.Dietary arginine supplementation of mice alters the microbial population and activates intestinal innate immunity[J].The Journal of Nutrition,2014,144(6):988-995.

[24] GAO F,GAO E H, YUE T L,et al.Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion:the roles of PI3-kinase,
Akt,and endothelial nitric oxide synthase phosphorylation[J].Circulation,2002,105(12):1497-1502.

[25] PLISETSKAYA E M,BUCHELLI-NARVAEZ L I,HARDY R W.Effects of injected and dietary arginine on plasma insulin levels and growth of pacific salmon and rainbow trout[J].Comparative Biochemistry and Physiology Part A:Physiology,1991,98(1):165-170.

[26] ANDOH T.Amino acids are more important insulinotropins than glucose in a teleost fish,barfin flounder (
Verasper moseri)[J].General and Comparative Endocrinology,2007,151(3):308-317.

[27] POHLENZ C,BUENTELLO A,HELLAND S L J,et al.Effects of dietary arginine supplementation on growth,protein optimization and innate immune response of channel catfish
Ictalurus punctatus (Rafinesque 1818)[J].Aquaculture Research,2014,45(3):491-500.

[28] HOLLAND M C H,LAMBRIS J D.The complement system in teleosts[J].Fish & Shellfish Immunology,2002,12(5):399-420.

[29] ZHOU H,CHEN N,QIU X,et al.Arginine requirement and effect of arginine intake on immunity in largemouth bass,
Micropterus salmoides[J].Aquaculture Nutrition,2012,18(1):107-116.

[30] JENKINS J A,OURTH D D.Opsonic effect of the alternative complement pathway on channel catfish peripheral blood phagocytes[J].Veterinary Immunology and Immunopathology,1993,39(4):447-459.

[31] ZHANG G Y,HAN J Y,WELCH E J,et al.Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4/MyD88 and the cGMP-dependent protein kinase pathway[J].Journal of Immunology,2009,182(12):7997-8004.

[32] FOEY A D,PARRY S L,WILLIAMS L M,et al.Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-α Role of the p38 and p42/44 mitogen-activated protein kinases[J].The Journal of Immunology,1998,160(2):920-928.
[33] REDDY K P,MARKOWITZ J E,RUCHELLI E D.Lamina propria and Circulating interleukin-8 in newly and previously diagnosed pediatric inflammatory bowel disease patients[J].Digestive Diseases and Sciences,2007,52(2):365-372.

[34] TSE K H,CHOW K B S,LEUNG W K,et al.Lipopolysaccharide differentially modulates expression of cytokines and cyclooxygenases in dorsal root ganglion cells via Toll-like receptor-4 dependent pathways[J].Neuroscience,2014,267:241-251.
[35] CONNELLY L,PALACIOS-CALLENDER M,AMEIXA C,et al.Biphasic regulation of NF-KB activity underlies the pro- and ant-inflammatory actions of nitric oxide[J].Journal of Immunology,2001,166(3):3873- 3881.
[36] REN M C,AI Q H,MAI K S.Dietary arginine requirement of juvenile cobia (
Rachycentron canadum)[J].Aquaculture Research,2014,45(2):225-233.

[37] ANDOH T.Stress inhibits insulin release induced by feeding and arginine injection in barfin flounder
Verasper moseri[J].Fisheries Science,2014,80(2):311-316.

[38] POHLENZ C,BUENTELLO A,CRISCITIELLO M F,et al.Synergies between vaccination and dietary arginine and glutamine supplementation improve the immune response of channel catfish against
Edwardsiella ictaluri[J].Fish & Shellfish Immunology,2012,33(3):543-551.

[39] ACTON R T,WEINHEIMER P F,HALL S J,et al.Tetrameric immune macroglobulins in three orders of bony fishes[J].Proceedings of the National Academy of Sciences of the United States of America 1971,68(1):107-111.
[40] BURTON O T,NOVAL RIVAS M,ZHOU J S,et al.Immunoglobulin E signal inhibition during allergen ingestion leads to reversal of established food allergy and induction of regulatory T cells[J].Immunity,2014,41(1):141-151.

[41] YU H R,KUO H C,HUANG L T,et al.L-arginine modulates neonatal lymphocyte proliferation through an interleukin-2 independent pathway[J].Immunology,2014,143(2):184-192.