综述 Review

精氨酸对鱼类免疫功能的影响及其机制

展开
  • 1. 四川农业大学动物科技学院, 成都 611130;
    2. 四川农业大学动物营养研究所, 成都 611130
石丹(1991—),女,四川达州人,硕士研究生,从事水产动物营养与饲料学研究。E-mail:2418371493@qq.com

收稿日期: 2015-05-10

  网络出版日期: 2015-10-15

基金资助

四川省应用基础研究项目(2015JY0067)

Effects of Arginine on Immune Function in Fish and Its Mechanism

Expand
  • 1. College of Animal Science, Sichuan Agricultural University, Chengdu 611130, China;
    2. Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China

Received date: 2015-05-10

  Online published: 2015-10-15

摘要

精氨酸是鱼类的必需氨基酸,能增强鱼鳃组织物理屏障功能,提高吞噬细胞吞噬能力和杀菌活性,提高抗菌物质杀菌活性和免疫球蛋白含量,以增强鱼类非特异性和特异性免疫功能。同时,精氨酸具有抗炎作用,能保护鱼体免受免疫应答的自我损伤。本文简要综述精氨酸对鱼类免疫功能的影响及其机制。

本文引用格式

石丹, 周小秋, 赵叶, 姜俊 . 精氨酸对鱼类免疫功能的影响及其机制[J]. 动物营养学报, 2015 , 27(10) : 3026 -3032 . DOI: 10.3969/j.issn.1006-267x.2015.10.006

Abstract

Arginine, as an essential amino acid for fish, can enhance physical barrier function of fish gill, improve the phagocytosis and bactericidal activity of phagocytes, the activity of lysozyme and complement, and increase antibody titer.Thus arginine can improve the fish innate and adaptive immune function.At the same time, arginine exerts anti-inflammatory effect to protect the fish from self-damage during immune response.This article mainly aimed to review the effects of arginine on fish immune function and its mechanism.

参考文献

[1] ZHU L Y,NIE L,ZHU G,et al.Advances in research of fish immune-relevant genes:a comparative overview of innate and adaptive immunity in teleosts[J].Developmental & Comparative Immunology,2013,39 (1/2):39-62.

[2] KIRON V.Fish immune system and its nutritional modulation for preventive health care[J].Animal Feed Science and Technology,2012,173(1/2):111-133.

[3] WEST N E J,QIAN H S,GUZIK T J,et al.Nitric oxide synthase (nNOS) gene transfer modifies venous bypass graft remodeling:effects on vascular smooth muscle cell differentiation and superoxide production[J].Circulation,2001,104(13):1526-1532.  

[4] CHEN G F,LIU Y,JIANG J,et al.Effect of dietary arginine on the immune response and gene expression in head kidney and spleen following infection of Jian carp with Aeromonas hydrophila[J].Fish & Shellfish Immunology,2015,44(1):195-202.  

[5] COSTAS B,CONCEIÇÀO L E C,DIAS J,et al.Dietary arginine and repeated handling increase disease resistance and modulate innate immune mechanisms of Senegalese sole (Solea senegalensis Kaup,1858)[J].Fish & Shellfish Immunology,2011,31(6):838-847.  

[6] COSTAS B,GÊGO P C N P,CONCEIÇÀ L E C,et al.Dietary arginine supplementation decreases plasma cortisol levels and modulates immune mechanisms in chronically stressed turbot (Scophthalmus maximus)[J].Aquaculture Nutrition,2013,19(Suppl.1):25-38.

[7] HOLEN E,ESPE M,ANDERSEN S M,et al.A co culture approach show that polyamine turnover is affected during inflammation in Atlantic salmon immune and liver cells and that arginine and LPS exerts opposite effects on p38MAPK signaling[J].Fish & Shellfish Immunology,2014,37(2):286-298.  

[8] JIANG J,SHI D,ZHOU X Q,et al.In vitro and in vivo protective effect of arginine against lipopolysaccharide induced inflammatory response in the intestine of juvenile Jian carp (Cyprinus carpio var.Jian)[J].Fish & Shellfish Immunology,2015,42(2):457-464.  

[9] WANG B,FENG L,JIANG W D,et al.Copper-induced tight junction mRNA expression changes,apoptosis and antioxidant responses via NF-κB,TOR and Nrf2 signaling molecules in the gills of fish:preventive role of arginine[J].Aquatic toxicology,2015,158:125-137.

[10] ZHAO J,FENG L,LIU Y,et al.Effect of dietary isoleucine on the immunity,antioxidant status,tight junctions and microflora in the intestine of juvenile Jian carp (Cyprinus carpio var.Jian)[J].Fish & Shellfish Immunology,2014,41(2):663-673.  

[11] WEN H L,FENG L,JIANG W D,et al.Dietary tryptophan modulates intestinal immune response,barrier function,antioxidant status and gene expression of TOR and Nrf2 in young grass carp (Ctenopharyngodon idella)[J].Fish & Shellfish Immunology,2014,40(1):275-287.  

[12] LUSHCHAK V I.Environmentally induced oxidative stress in aquatic animals[J].Aquatic Toxicology,2011,101(1):13-30.  

[13] WANG B,LIU Y,FENG L,et al.Effects of dietary arginine supplementation on growth performance,flesh quality,muscle antioxidant capacity and antioxidant-related signalling molecule expression in young grass carp (Ctenopharyngodon idella)[J].Food Chemistry,2015,167:91-99.

[14] DELERIVE P,FRUCHART J C,STAELS B.Peroxisome proliferator-activated receptors in inflammation control[J].The Journal of Endocrinol,2001,169:453-459.

[15] NIKLASSON L.Intestinal mucosal immunology of salmonids response to stress and infection and crosstalk with the physical barrier[D].Ph.D.Thesis.Geoteborg:University of Gothenburg,2013.

[16] BEUTHEU S,GHOUZALI I,GALAS L,et al.Glutamine and arginine improve permeability and tight junction protein expression in methotrexate-treated Caco-2 cells[J].Clinical Nutrition,2013,32(5):863-869.  

[17] FUJITA H,CHIBA H,YOKOZAKI H,et al.Differential expression and subcellular localization of Claudin-7,-8,-12,-13,and -15 along the mouse intestine[J].Journal of Histochemistry & Cytochemistry,2006,54(8):933-944.  

[18] POHLENZ C,BUENTELLO A,MWANGI W,et al.Arginine and glutamine supplementation to culture media improves the performance of various channel catfish immune cells[J].Fish & Shellfish Immunology,2012,32(5):762-768.  

[19] BUENTELLO J A,REYES-BECERRIL M,ROMERO-GERALDO M D J,et al.Effects of dietary arginine on hematological parameters and innate immune function of channel catfish[J].Journal of Aquatic Animal Health,2007,19(3):195-203.  

[20] CHENG Z Y,BUENTELLO A,GATLIN D M Ⅲ.Effects of dietary arginine and glutamine on growth performance,immune responses and intestinal structure of red drum,Sciaenops ocellatus[J].Aquaculture,2011,319(1/2):247-252.

[21] CHENG Z Y,GATLIN D M Ⅲ,BUENTELLO A.Dietary supplementation of arginine and/or glutamine influences growth performance,immune responses and intestinal morphology of hybrid striped bass (Morone chrysops×Morone saxatilis)[J].Aquaculture,2012,362-363:39-43.

[22] WEYTS F A A,FLIK G,VERBURG-VAN KEMENADE B M L.Cortisol inhibits apoptosis in carp neutrophilic granulocytes[J].Developmental & Comparative Immunology,1998,22(5/6):563-572.

[23] REN W K,CHEN S,YIN J,et al.Dietary arginine supplementation of mice alters the microbial population and activates intestinal innate immunity[J].The Journal of Nutrition,2014,144(6):988-995.  

[24] GAO F,GAO E H, YUE T L,et al.Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion:the roles of PI3-kinase,Akt,and endothelial nitric oxide synthase phosphorylation[J].Circulation,2002,105(12):1497-1502.  

[25] PLISETSKAYA E M,BUCHELLI-NARVAEZ L I,HARDY R W.Effects of injected and dietary arginine on plasma insulin levels and growth of pacific salmon and rainbow trout[J].Comparative Biochemistry and Physiology Part A:Physiology,1991,98(1):165-170.  

[26] ANDOH T.Amino acids are more important insulinotropins than glucose in a teleost fish,barfin flounder (Verasper moseri)[J].General and Comparative Endocrinology,2007,151(3):308-317.  

[27] POHLENZ C,BUENTELLO A,HELLAND S L J,et al.Effects of dietary arginine supplementation on growth,protein optimization and innate immune response of channel catfish Ictalurus punctatus (Rafinesque 1818)[J].Aquaculture Research,2014,45(3):491-500.  

[28] HOLLAND M C H,LAMBRIS J D.The complement system in teleosts[J].Fish & Shellfish Immunology,2002,12(5):399-420.  

[29] ZHOU H,CHEN N,QIU X,et al.Arginine requirement and effect of arginine intake on immunity in largemouth bass,Micropterus salmoides[J].Aquaculture Nutrition,2012,18(1):107-116.  

[30] JENKINS J A,OURTH D D.Opsonic effect of the alternative complement pathway on channel catfish peripheral blood phagocytes[J].Veterinary Immunology and Immunopathology,1993,39(4):447-459.  

[31] ZHANG G Y,HAN J Y,WELCH E J,et al.Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4/MyD88 and the cGMP-dependent protein kinase pathway[J].Journal of Immunology,2009,182(12):7997-8004.  

[32] FOEY A D,PARRY S L,WILLIAMS L M,et al.Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-α Role of the p38 and p42/44 mitogen-activated protein kinases[J].The Journal of Immunology,1998,160(2):920-928.

[33] REDDY K P,MARKOWITZ J E,RUCHELLI E D.Lamina propria and Circulating interleukin-8 in newly and previously diagnosed pediatric inflammatory bowel disease patients[J].Digestive Diseases and Sciences,2007,52(2):365-372.  

[34] TSE K H,CHOW K B S,LEUNG W K,et al.Lipopolysaccharide differentially modulates expression of cytokines and cyclooxygenases in dorsal root ganglion cells via Toll-like receptor-4 dependent pathways[J].Neuroscience,2014,267:241-251.

[35] CONNELLY L,PALACIOS-CALLENDER M,AMEIXA C,et al.Biphasic regulation of NF-KB activity underlies the pro- and ant-inflammatory actions of nitric oxide[J].Journal of Immunology,2001,166(3):3873- 3881.

[36] REN M C,AI Q H,MAI K S.Dietary arginine requirement of juvenile cobia (Rachycentron canadum)[J].Aquaculture Research,2014,45(2):225-233.  

[37] ANDOH T.Stress inhibits insulin release induced by feeding and arginine injection in barfin flounder Verasper moseri[J].Fisheries Science,2014,80(2):311-316.  

[38] POHLENZ C,BUENTELLO A,CRISCITIELLO M F,et al.Synergies between vaccination and dietary arginine and glutamine supplementation improve the immune response of channel catfish against Edwardsiella ictaluri[J].Fish & Shellfish Immunology,2012,33(3):543-551.  

[39] ACTON R T,WEINHEIMER P F,HALL S J,et al.Tetrameric immune macroglobulins in three orders of bony fishes[J].Proceedings of the National Academy of Sciences of the United States of America 1971,68(1):107-111.

[40] BURTON O T,NOVAL RIVAS M,ZHOU J S,et al.Immunoglobulin E signal inhibition during allergen ingestion leads to reversal of established food allergy and induction of regulatory T cells[J].Immunity,2014,41(1):141-151.  

[41] YU H R,KUO H C,HUANG L T,et al.L-arginine modulates neonatal lymphocyte proliferation through an interleukin-2 independent pathway[J].Immunology,2014,143(2):184-192.  
文章导航

/