综述 Review

腺苷酸活化蛋白激酶信号转导通路在奶牛酮病发生和发展过程中的调控机制

  • 董记红 ,
  • 吴金节 ,
  • 王希春 ,
  • 冯士彬 ,
  • 丁红研 ,
  • 刘国文 ,
  • 李心慰 ,
  • 李小兵 ,
  • 王哲 ,
  • 李玉
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  • 1. 安徽农业大学动物科技学院, 合肥 230036;
    2. 吉林大学动物医学学院, 长春 130062

收稿日期: 2015-10-15

  网络出版日期: 2016-04-11

基金资助

安徽农业大学青年科学基金项目(2014zr008);国家自然科学基金项目(31172372,31502136)

Adenosine Monophosphate-Activated Protein Kinase Signal Transduction Pathways:Regulation Mechanism in Process of Cow Ketosis Occurrence and Development

  • DONG Jihong ,
  • WU Jinjie ,
  • WANG Xichun ,
  • FENG Shibin ,
  • DING Hongyan ,
  • LIU Guowen ,
  • LI Xinwei ,
  • LI Xiaobing ,
  • WANG Zhe ,
  • LI Yu
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  • 1. College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China;
    2. College of Veterinary Medicine, Jilin University, Changchun 130062, China

Received date: 2015-10-15

  Online published: 2016-04-11

摘要

奶牛酮病是围产期奶牛常见的营养代谢性疾病,给奶牛业造成了巨大的损失。奶牛酮病发生时,相关的能量代谢激素也发生了明显的变化,主要是胰高血糖素和胰岛素。腺苷酸活化蛋白激酶被认为是机体的能量感受器,一些能量代谢激素可以引起其活性的变化。本文就胰高血糖素和胰岛素对腺苷酸活化蛋白激酶信号转导通路发生作用机制做一论述,旨在为下一步研究奶牛酮病提供理论支持。

本文引用格式

董记红 , 吴金节 , 王希春 , 冯士彬 , 丁红研 , 刘国文 , 李心慰 , 李小兵 , 王哲 , 李玉 . 腺苷酸活化蛋白激酶信号转导通路在奶牛酮病发生和发展过程中的调控机制[J]. 动物营养学报, 2016 , 28(4) : 1035 -1041 . DOI: 10.3969/j.issn.1006-267x.2016.04.010

Abstract

Cow ketosis is a common nutritional and metabolic disease during perinatal, which has caused tremendous losses to the dairy industry. Related energy metabolic hormones have undergone tremendous changes when ketosis occurs, mainly including glucagon and insulin. Adenosine monophosphate-activated protein kinase(AMPK) is considered to be an energy sensor, some energy metabolic hormones can cause changes of AMPK activity. This article focused on the role of glucagon and insulin in AMPK signal transduction pathways aimed at providing theoretical support for further research in cow ketosis.

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