综述 Review

隐性乳房炎奶牛乳蛋白含量降低的信号转导机制探讨

  • 张旭 ,
  • 徐丹丹 ,
  • 杨彬 ,
  • 贺显晶 ,
  • 王建发 ,
  • 武瑞
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  • 黑龙江八一农垦大学动物科技学院, 大庆 163319

收稿日期: 2016-06-13

  网络出版日期: 2016-12-17

基金资助

国家自然科学基金项目(31472249,31402157);黑龙江省普通本科高校青年创新人才培养计划(UNPYSCT-2015087);黑龙江八一农垦大学博士科研启动基金(XYB2014-12);黑龙江八一农垦大学研究生创新科研项目(YJSCX2016-Y13)

Signal Transduction Mechanism of Milk Protein Content Depression Induced by Subclinical Mastitis in Dairy Cows

  • ZHANG Xu ,
  • XU Dandan ,
  • YANG Bin ,
  • HE Xianjing ,
  • WANG Jianfa ,
  • WU Rui
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  • College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China

Received date: 2016-06-13

  Online published: 2016-12-17

摘要

乳蛋白是决定牛奶营养品质的主要乳成分之一,具有较高的营养价值,含有人体几乎所有的必需氨基酸。乳蛋白含量和组成受多种因素的影响,除品种、胎次、环境、奶牛泌乳阶段、饲粮组成与营养水平外,疾病也是影响乳汁中乳蛋白含量和组成的重要因素。其中,奶牛隐性乳房炎可以引起乳汁中乳蛋白含量的降低。本文主要探讨乳蛋白的合成机理及隐性乳房炎时乳蛋白含量降低的信号转导机制,旨在为研究在奶牛患隐性乳房炎条件下提高乳蛋白含量的方法提供一些思路和参考。

本文引用格式

张旭 , 徐丹丹 , 杨彬 , 贺显晶 , 王建发 , 武瑞 . 隐性乳房炎奶牛乳蛋白含量降低的信号转导机制探讨[J]. 动物营养学报, 2016 , 28(12) : 3757 -3762 . DOI: 10.3969/j.issn.1006-267x.2016.12.006

Abstract

Milk protein is one of main substances determining nutritional quality of cows' milk. Milk protein has high nutritional value and contains almost all essential amino acids required by human. The content of milk protein is affected by many factors, in addition to breed, parity, environment, lactation stage, and diet composition and nutrient level. Diseases are also an important factor affecting milk protein content and composition, and subclinical mastitis can cause milk protein to reduce. This paper mainly expounded the mechanism of milk protein synthesis and signal transduction mechanism of milk protein content decreased under by subclinical mastitis, hoping that the review could provide a reference for further study on methods to improve the content of milk protein.

参考文献

[1] 王晓艳,张娜,高学军,等.奶牛乳腺对血液游离氨基酸吸收的差异性研究[J].中国乳品工业,2013,41(1):8-10,14.

[2] 秦宜德,邹思湘.乳蛋白的主要组分及其研究现状[J].生物学杂志,2003,20(2):5-7.

[3] DOS REIS C B M,BARREIRO J R,MESTIERI L,et al.Effect of somatic cell count and mastitis pathogens on milk composition in Gyr cows[J].BMC Veterinary Research,2013,9(2):67.

[4] 陈静廷,马露,杨晋辉,等.差异蛋白质组学在乳蛋白研究中的应用进展[J].动物营养学报,2013,25(8):1683-1688.

[5] ZHOU Y,SONG F,LI Y S,et al.Double-antibody based immunoassay for the detection of β-casein in bovine milk samples[J].Food Chemistry,2013,141(1):167-173.  

[6] GARDNER B,FELDMAN J.Are positive axillary nodes in breast cancer markers for incurable disease?[J].Annals of Surgical,1993,218(3):270-275.  

[7] BIONAZ M,LOOR J J.Gene networks driving bovine mammary protein synthesis during the lactation cycle[J].Bioinformatics and Biology Insights,2011,5:83-98.

[8] 王光文.提高乳蛋白的综合技术[J].乳业科学与技术,2007,30(1):29-35.

[9] HAYASHI A A.Regulation of protein synthesis in the mammary gland[D].Palmerston North:Massey University,2007:12-15.

[10] FRASOR J,BARKAI U,ZHONG L,et al.PRL-induced ERalpha gene expression is mediated by Janus kinase 2(JAK2) while signal transducer and activator of transcription 5b (STAT5b) phosphorylation involves JAK2 and a second tyrosine kinase[J].Molecular Endocrinology,2001,15(11):1941-1952.

[11] COOPER J C,BOUSTEAD J N,YU C L.Characterization of STAT5B phosphorylation correlating with expression of cytokine-inducible SH2-containing protein (CIS)[J].Cellular Signalling,2006,18(6):851-860.  

[12] LEVY D E,DARNELL J E.STATs:transcriptional control and biological impact[J].Nature Reviews Molecular Cell Biology,2002,3(9):651-662.  

[13] HARDIE G D.AMP-activated/SNF1 protein kinases:conserved guardians of cellular energy[J].Nature Reviews Molecular Cell Biology,2007,8(10):774-785.  

[14] BRAZIL D P,HEMMINGS B A.Ten years of protein kinase B signalling:a hard Akt to follow[J].Trends in Biochemical Sciences,2001,26(11):657-664.  

[15] 綦松智,吴登俊,张中显.mTOR对信号通路调控的研究进展[J].中国畜牧杂志,2010,46(1):57-60.

[16] HAY N,SONENBERG N.Upstream and downstream of mTOR[J].Genes & Development,2004,18(16):1926-1945.  

[17] XU G,ZHANG W,BERTRAM P,et al.Pharmacogenomic profiling of the PI3K/PTEN-AKT-mTOR pathway in common human tumors[J].International Journal of Oncology,2004,24(4):893-900.

[18] PENE F,CLAESSENS Y E,MULLER O,et al.Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma[J].Oncogene,2002,21(43):6587-6597.  

[19] PROUD C G.Amino acids and mTOR signalling in anabolic function[J].Biochemical Society Transactions,2007,35(5):1187-1190.  

[20] BEUGNET A,TEE A R,TAYLOR P M,et al.Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid avail ability[J].Biochemical Journal,2003,372(2):555-566.  

[21] BURGOS S A,DAI M,CANT J P.Nutrient availability and lactogenic hormones regulate mammary protein synthesis through the mammalian target of rapamycin signaling pathway[J].Journal of Dairy Science,2010,93(1):153-161.  

[22] 陈洪菊,屈艺,母得志.mTOR信号通路的生物学功能[J].生命的化学,2010,30(4):555-561.

[23] LYNCH C J.Role of leucine in the regulation of mTOR by amino acids:revelations from structure-activity studies[J].The Journal of Nutrition,2001,131(3):861S-865S.

[24] GUNTHER J,ESCH K,POSCHADEL N,et al.Comparative kinetics of Escherichia coli-and Staphylococcus aureus-specific activation of key immune pathways in mammary epithelial cells demonstrates that S.aureus elicits a delayed response dominated by interleukin-6(IL-6) but not by IL-1A or tumor necrosis factor alpha[J].Infection and Immunity,2011,79(2):695-707.  

[25] LIU B,ZHANG N S,LIU Z C,et al.RP105 involved in activation of mouse macrophages via TLR2 and TLR4 signaling[J].Molecular and Cellular Biochemistry,2013,378(1/2):183-193.

[26] YOSHIMURA A,NAKA T,KUBO M.SOCS proteins,cytokine signalling and immune regulation[J].Nature Reviews Immunology,2007,7(6):454-465.  

[27] ENDO T A,MASUHARA M,YOKOUCHI M,et al.A new protein containing an SH2 domain that inhibits JAK kinases[J].Nature,1997,387(6636):921-924.  

[28] ZHENG J M,WATSON A D,KERR D E.Genome-wide expression analysis of lipopolysaccharide-induced mastitis in a mouse model[J].Infection and Immunity,2006,74(3):1907-1915.  

[29] JIANG L,SØRENSEN P, RØNTVED C,et al.Gene expression profiling of liver from dairy cows treated intra-mammary with lipopolysaccharide[J].BMC Genomics,2008,9(1):443.

[30] TAMIYA T,KASHIWAGI I,TAKAHASHI R,et al.Suppressors of cytokine signaling (SOCS) proteins and JAK/STAT pathways:regulation of T-cell inflammation by SOCS1 and SOCS3[J].Arteriosclerosis,Thrombosis,and Vascular Biology,2011,31(5):980-985.  

[31] YAN C G,CAO J,WU M,et al.Suppressor of cytokine signaling 3 inhibits LPS-induced IL-6 expression in osteoblasts by suppressing CCAAT/enhancer-binding protein β activity[J].Journal of Biological Chemistry,2010,285(48):37227-37239.  

[32] RAM P A,WAXMAN D J.SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms[J].Journal of Biological Chemistry,1999,274(50):35553-35561.  

[33] KIMURA A,NAKA T,MUTA T,et al.Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT[J].Proceedings of The National Academy of Sciences of the United States of America,2005,102(47):17089-17094.  

[34] KREBS D L,HILTON D J.SOCS:physiological suppressors of cytokine signaling[J].Journal of Cell Science,2000,113(16):2813-2819.

[35] HUANG Y L,ZHAO F,LUO C C,et al.SOCS3-mediated blockade reveals major contribution of JAK2/STAT5 signaling pathway to lactation and proliferation of dairy cow mammary epithelial cells in Vitro[J].Molecules,2013,18(10):12987-13002.  

[36] TORNATORE L,THOTAKURA A K,BENNETT J,et al.The nuclear factor kappa B signaling pathway:integrating metabolism with inflammation[J].Trends in Cell Biology,2012,22(11):557-566.  

[37] PARK S,ZHAO D W,HATANPAA K J,et al.RIP1 activates PI3K-Akt via a dual mechanism involving NF-κB-mediated inhibition of the mTOR-S6K-IRS1 negative feedback loop and down-regulation of PTEN[J].Cancer Research,2009,69(10):4107-4111.  

[38] OP DEN KAMP C M,LANGEN R C,SNEPVANGERS F J,et al.Nuclear transcription factor κB activation and protein turnover adaptations in skeletal muscle of patients with progressive stages of lung cancer cachexia[J].American Journal of Clinical Nutrition,2013,98(3):738-748.  

[39] SRIVASTAVA D S L,DHAULAKHANDI D B.Role of NF-κB in loss of skeletal muscle mass in cancer cachexia and its therapeutic targets[J].American Journal of Cancer Biology,2013,2(1):1-16.
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