综述 Review

二十二碳六烯酸的生理学功能及其在家禽生产中的应用

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  • 中国农业科学院饲料研究所, 农业部饲料生物技术重点开放试验室, 生物饲料开发国家工程研究中心, 北京 100081
龙烁(1993-),女,山东临沂人,硕士研究生,从事家禽营养与饲料科学研究。E-mail:maplega@163.com

收稿日期: 2016-10-01

  网络出版日期: 2017-04-14

基金资助

现代农业产业技术体系(CARS-41-K13);家禽产业技术体系北京市创新团队(CARS-PSTP)

Biological Functions and Mechanisms of Docosahexaenoic Acid and Its Application in Poultry Production

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  • National Engineering Research Center of Biological Feed, Key Laboratory of Feed Biotechnology of Ministry of Agriculture, Feed Research Institute, Chinese Academy of Agricultural Science, Beijing 100081, China

Received date: 2016-10-01

  Online published: 2017-04-14

摘要

二十二碳六烯酸(DHA)属于ω-3系列长链多不饱和脂肪酸,对机体有重要的生理功能。本文综述了DHA的生理学功能、代谢机理、不同DHA来源的比较以及在家禽生产中的应用,旨在为DHA在家禽生产中的科学应用提供理论依据。

本文引用格式

龙烁, 王浩, 武书庚, 齐广海, 张海军, 王晶 . 二十二碳六烯酸的生理学功能及其在家禽生产中的应用[J]. 动物营养学报, 2017 , 29(4) : 1101 -1109 . DOI: 10.3969/j.issn.1006-267x.2017.04.003

Abstract

As a ω-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA) plays an important role in human and animal's body. The biological functions and the metabolic mechanism of DHA, comparing the difference source of DHA and its applications in poultry production were reviewed in this paper aimed at providing the reference for DHA's scientific applications in poultry production.

参考文献

[1] LEMAHIEU C,BRUNEEL C,RYCKEBOSCH E,et al.Impact of different omega-3 polyunsaturated fatty acid (n-3 PUFA) sources (flaxseed,Isochrysis galbana,fish oil and DHA Gold) on n-3 LC-PUFA enrichment (efficiency) in the egg yolk[J].Journal of Functional Foods,2015,19:821-827.

[2] DYERBERG J,BANG H O,STOFFERSEN E,et al.Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis?[J].The Lancet,1978,312(8081):117-119.  

[3] UMEMURA K,TOSHIMA Y,ASAI F,et al.Effect of dietary docosahexaenoic acid in the rat middle cerebral artery thrombosis model[J].Thrombosis Research,1995,78(5):379-387.  

[4] MORI T A,BAO D Q,BURKE V,et al.Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans[J].Hypertension,1999,34(2):253-260

[5] GE L,WANG J,QI W,et al.The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1[J].Cell Metabolism,2008,7(6):508-519.  

[6] MATHUR S N,WATT K R,FIELD F J.Regulation of intestinal NPC1L1 expression by dietary fish oil and docosahexaenoic acid[J].Journal of Lipid Research,2007,48(2):395-404.

[7] FRØYLAND L,VAAGENES H,ASIEDU D K,et al.Chronic administration of eicosapentaenoic acid and docosahexaenoic acid as ethyl esters reduced plasma cholesterol and changed the fatty acid composition in rat blood and organs[J].Lipids,1996,31(2):169-178.  

[8] CHEN Z Y,JIAO R,MA K Y.Cholesterol-lowering nutraceuticals and functional foods[J].Journal of Agricultural and Food Chemistry,2008,56(19):8761-8773.  

[9] 汪鲲.n-3多不饱和脂肪酸在蛋黄和组织中的富集规律及其对产蛋鸡脂类代谢的影响[D].博士学位论文.北京:中国农业科学院,2000.

[10] 陈秀丽.不同来源n-3 PUFA在蛋鸡中应用效果的评价[D].硕士学位论文.杨凌:西北农林科技大学,2014.

[11] GUESNET P,ALESSANDRI J M.Docosahexaenoic acid (DHA) and the developing central nervous system (CNS)-implications for dietary recommendations[J].Biochimie,2011,93(1):7-12.  

[12] 曹万新,孟橘,田玉霞.DHA的生理功能及应用研究进展[J].中国油脂,2011,36(3):1-4.

[13] LAMPTEY M S,WALKER B L.A possible essential role for dietary linolenic acid in the development of the young rat[J].Journal of Nutrition,1976,106(1):86-93.

[14] 李红娟,刘德华,张恩平.发育期补充鱼油对大鼠脑内脂肪酸组成及神经递质的影响[C]//达能营养中心青年科学工作者论坛优秀论文集2000年第1期.北京:中国疾病预防控制中心达能营养中心,2000:47-49.

[15] 马琴,王静凤,王玉明,等.二十二碳六烯酸-磷脂脂质体对东莨菪碱所致痴呆小鼠智力的影响研究[J].中国海洋大学学报,2009,39(增刊):69-72.

[16] 岳崟.多不饱和脂肪酸提高发育期大鼠空间学习记忆的机制[D].硕士学位论文.武汉:武汉轻工大学,2015.

[17] O'CONNOR D L,HALL R,ADAMKIN D,et al.Growth and development in preterm infants fed long-chain polyunsaturated fatty acids:a prospective, randomized controlled trial[J].Pediatrics,2001,108(2):359-371.  

[18] DECSI T,KOLETZKO B.N-3 fatty acids and pregnancy outcomes[J].Current Opinion in Clinical Nutrition and Metabolic Care,2005,8(2):161-166.  

[19] VAN DE LAGEMAAT M,ROTTEVEEL J,MUSKIET F A J,et al.Post term dietary-induced changes in DHA and AA status relate to gains in weight,length,and head circumference in preterm infants[J].Prostaglandins,Leukotrienes and Essential Fatty Acids,2011,85(6):311-316.  

[20] HUFFMAN S L,HARIKA R K,EILANDER A,et al.Essential fats:how do they affect growth and development of infants and young children in developing countries? A literature review[J].Maternal & Child Nutrition,2011,7(Suppl.3):44-65.

[21] WILLATTS P,FORSYTH J S,DIMODUGNO M K,et al.Effect of long-chain polyunsaturated fatty acids in infant formula on problem solving at 10 months of age[J].The Lancet,1998,352(9129):688-691.  

[22] HORROCKS L A,YEO Y K.Health benefits of docosahexaenoic acid (DHA)[J].Pharmacological Research,1999,40(3):211-225.  

[23] BOSETTI C,NEGRI E,FRANCESCHI S,et al.Diet and ovarian cancer risk:a case-control study in Italy[J].International Journal of Cancer,2001,93(6):911-915.  

[24] TIMMER-BOSSCHA H,HOSPERS G A P,MEIJER C,et al.Influence of docosahexaenoic acid on cisplatin resistance in a human small cell lung carcinoma cell line[J].Journal of the National Cancer Institute,1989,81(14):1069-1075.  

[25] WOODWORTH H L,MCCASKEY S J,CLINTHORNE J,et al.DHA exacerbates experimentally induced colitis in SMAD3-/- mice[J].The FASEB Journal,2010,24(Suppl.1):728.1.

[26] LU I F,HASIO A C,HU M C,et al.Docosahexaenoic acid induces proteasome-dependent degradation of estrogen receptor α and inhibits the downstream signaling target in MCF-7 breast cancer cells[J].Journal of Nutrition Biochemistry,2010,21(6):512-517.  

[27] 赵丽,孙克任,鲍蕾,等.DHA复合物对鼠移植瘤细胞和T淋巴细胞细胞周期及凋亡的影响[J].肿瘤,2004,24(3):223-225.

[28] 隋英忠,薛美兰,葛银林,等.DHA诱导小鼠乳癌4T1细胞凋亡及其对死亡受体蛋白表达的影响[J].青岛大学医学院学报,2015,51(3):287-289,292.

[29] CALVIELLO G,DI NICUOLO F,GRAGNOLI S,et al.n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1α induction pathway[J].Carcinogenesis,2004,25(12):2303-2310.  

[30] HARDMAN W E.(n-3) fatty acids and cancer therapy[J].The Journal of Nutrition,2004,134(12):3427S-3430S.

[31] 孙思楠.DHA对人肝癌细胞凋亡和侵袭力的影响及其机制研究[D].博士学位论文.合肥:安徽医科大学,2013.

[32] WATKINS S M,CARTER L C,GERMAN J B.Docosahexaenoic acid accumulates in cardiolipin and enhances HT-29 cell oxidant production[J].Journal of Lipid Research,1998,39(8):1583-1588.

[33] PARADIES G,PETROSILLO G,PISTOLESE M,et al.Lipid peroxidation and alterations to oxidative metabolism in mitochondria isolated from rat heart subjected to ischemia and reperfusion[J].Free Radical Biology and Medicine,1999,27(1/2):42-50.

[34] BELIKOVA N A,JIANG J F,TYURINA Y Y,et al.Cardiolipin-specific peroxidase reactions of cytochrome c in mitochondria during irradiation-induced apoptosis[J].International Journal of Radiation Oncology Biology Physics,2007,69(1):176-186.  

[35] LARSSON S C,KUMLIN M,INGELMAN-SUNDBERG M,et al.Dietary long-chain n-3 fatty acids for the prevention of cancer:a review of potential mechanisms[J].American Journal of Clinical Nutrition,2004,79(6):935-945.

[36] JHO D H,COLE S M,LEE E M,et al.Role of omega-3 fatty acid supplementation in inflammation and malignancy[J].Integrative Cancer Therapies,2004,3(2):98-111.  

[37] MORI T A,BEILIN L J.Omega-3 fatty acids and inflammation[J].Current Atherosclerosis Reports,2004,6(6):461-467.  

[38] TONTONOZ P,SPIEGELMAN B M.Fat and beyond:the diverse biology of PPARγ[J].Annual Review of Biochemistry,2008,77(1):289-312.  

[39] 王益兵.EPA与DHA调控肉仔鸡肠道B淋巴细胞免疫功能的机理[D].博士学位论文.杨凌:西北农林科技大学,2011.

[40] KORVER D R,KLASING K C.Dietary fish oil alters specific and inflammatory immune responses in chicks[J].The Journal of Nutrition,1997,127(10):2039-2046.

[41] FRITSCHE K L,CASSOITY N A,HUANG S C.Effect of dietary fat source on antibody production and lymphocyte proliferation in chickens[J].Poultry Science,1991,70(3):611-617.  

[42] AL-KHALIFA H,GIVENS D I,RYMER C,et al.Effect of n-3 fatty acids on immune function in broiler chickens[J].Poultry Science,2012,91(1):74-88.  

[43] GILROY D W.Eicosanoids and the endogenous control of acute inflammatory resolution[J].The International Journal of Biochemistry & Cell Biology,2010,42(4):524-528.  

[44] GALLI C,CALDER P C.Effects of fat and fatty acid intake on inflammatory and immune responses:a critical review[J].Annals of Nutrition & Metabolism,2009,55(1/2/3):123-139.

[45] KEW S,MESA M D,TRICON S,et al.Effects of oils rich in eicosapentaenoic and docosahexaenoic acids on immune cell composition and function in healthy humans[J].American Journal of Clinical Nutrition,2004,79(4):674-681.

[46] GREEN A G.From α to ω-producing essential fatty acids in plant[J].Nature Biotechnology,2004,22(6):680-682.  

[47] KABOURIDIS P S,JURY E C.Lipid rafts and T-lymphocyte function:implications for autoimmunity[J].FEBS Letters,2008,582(27):3711-3718.  

[48] KENWORTHY A K.Have we become overly reliant on lipid rafts? Talking point on the involvement of lipid rafts in T-cell activation[J].EMBO Reports,2008,9(6):531-535.  

[49] YAQOOB P.The nutritional significance of lipid rafts[J].Annual Review of Nutrition,2009,29:257-282.

[50] DE LIBERO G,MORI L.How the immune system detects lipid antigens[J].Progress in Lipid Research,2010,49(2):120-127.  

[51] LEMAHIEU C,BRUNEEL C,TERMOTE-VERHALLE R,et al.Effect of different microalgal n-3 PUFA supplementation doses on yolk color and n-3 LC-PUFA enrichment in the egg[J].Algal Research,2014,6:119-123.

[52] SUN Q X,LIU J,ZHANG Q,et al.Characterization of three novel desaturases involved in the delta-6 desaturation pathways for polyunsaturated fatty acid biosynthesis from Phytophthora infestans[J].Applied Microbiology and Biotechnology,2013,97(17):7689-7697.  

[53] LEONARD A E,PEREIRA S,SPRECHER H,et al.Elongation of long-chain fatty acids[J].Progress in Lipid Research,2004,43(1):36-54.  

[54] SAYANOVA O,HASLAM R P,CALERÓN M V,et al.Identification and functional characterisation of genes encoding the omega-3 polyunsaturated fatty acid biosynthetic pathway from the coccolithophore Emiliania huxleyi[J].Phytochemistry,2011,72(7):594-600

[55] MASTERSON C,WOOD C.Mitochondrial and peroxisomal β-oxidation capacities of organs from a non-oilseed plant[J].Proceedings of the Royal Society B:Biological Sciences,2001,268(1479):1949-1953.  

[56] QIU X.Biosynthesis of docosahexaenoic acid (DHA,22:6-4,7,10,13,16,19):two distinct pathways[J].Prostaglandins,Leukotrienes and Essential Fatty Acids,2003,68(2):181-186.  

[57] CACHALDORA P,GARCÍA-REBOLLAR P,ALVAREZ C,et al.Effect of type and level of basal fat and level of fish oil supplementation on yolk fat composition and n-3 fatty acids deposition efficiency in laying hens[J].Animal Feed Science and Technology,2008,141(1/2):104-114.

[58] CACHALDORA P,GARCÍA-REBOLLAR P,ALVAREZ C,et al.Effect of type and level of fish oil supplementation on yolk fat composition and n-3 fatty acids retention efficiency in laying hens[J].British Poultry Science,2006,47(1):43-49.  

[59] GONZALEZ-ESQUERRA R,LEESON S.Effect of feeding hens regular or deodorized menhaden oil on production parameters,yolk fatty acid profile,and sensory quality of eggs[J].Poultry Science,2000,79(11):1597-1602.  

[60] LAWLOR J B,GAUDETTE N,DICKSON T,et al.Fatty acid profile and sensory characteristics of table eggs from laying hens fed diets containing microencapsulated fish oil[J].Animal Feed Science and Technology,2010,156(3/4):97-103.

[61] JACOBS M N,COVACI A,SCHEPENS P.Investigation of selected persistent organic pollutants in farmed Atlantic salmon (Salmo salar),salmon aquaculture feed,and fish oil components of the feed[J].Environmental Science & Technology,2002,36(13):2797-2805.  

[62] 陈殊贤,郑晓辉.微藻油和鱼油中DHA的特性及应用研究进展[J].食品科学,2013,34(21):439-444.

[63] CRAWFIELD M A.Presentation at the omega-3 summit:global summit on nutrition,health and human behavior[M].Bruges,Belgium,2011.

[64] 陈继新,卢洁,夏中生,等.产蛋鸡日粮亚麻油水平对蛋黄脂肪组成及脂质代谢的影响[C]//第五届南京农业大学畜牧兽医学术年会——家禽高效养殖与重大疫病防控研讨会论文集.南京:南京农业大学,2011.

[65] RYCKEBOSCH E,BRUNEEL C,MUYLAERT K,et al.Microalgae as an alternative source of omega-3 long chain polyunsaturated fatty acids[J].Lipid Technology,2012,24(6):128-130.  

[66] KOMPRDA T.Eicosapentaenoic and docosahexaenoic acids as inflammation-modulating and lipid homeostasis influencing nutraceuticals:a review[J].Journal of Functional Foods,2012,4(1):25-38.  

[67] YAGUCHI T,TANAKA S,YOKOCHI T,et al.Production of high yields of docosahexaenoic acid by Schizochytrium sp. strain SR21[J].Journal of the American Oil Chemists' Society,1997,74(11):1431-1434.  

[68] 时艺霖,顾宪红,黄勇,等.紫苏籽提取物对蛋鸡产蛋高峰后期生产性能、生殖激素及免疫功能的影响[J].动物营养学报,2015,27(5):1519-1526.

[69] 臧素敏,李同洲,何万红,等.日粮中添加紫苏籽对鸡蛋黄脂肪酸组成及ω-3、ω-6影响的研究[J].河北农业大学学报,2003,26(1):65-68,72.

[70] LEESON S,CASTON L.Enrichment of eggs with lutein[J].Poultry Science,2004,83(10):1709-1712.  

[71] KARADAS F,GRAMMENIDIS E,SURAI P F,et al.Effects of carotenoids from lucerne,marigold and tomato on egg yolk pigmentation and carotenoid composition[J].British Poultry Science,2006,47(5):561-566.  

[72] JENSEN C L,MAUDE M,ANDERSON R E,et al.Effect of docosahexaenoic acid supplementation of lactating women on the fatty acid composition of breast milk lipids and maternal and infant plasma phospholipids[J].American Society for Clinical Nutrition,2000,71(Suppl.1):292S-299S.

[73] LAWSON L D,HUGHES B G.Human absorption of fish oil fatty acids as triacylglycerols,free acids,or ethyl esters[J].Biochemical and Biophysical Research Communications,1988,152(1):328-335.  

[74] BOSWELL K,KOSKELO E K,CARL L,et al.Preclinical evaluation of single-cell oils that are highly enriched with arachidonic acid and docosahexaenoic acid[J].Food and Chemical Toxicology,1996,34(7):585-593.  

[75] SELL J L,CHOO S H,KONDRA P A.Fatty acid composition of egg yolk and adipose tissue as influenced by dietary fat and strain of hen[J].Poultry Science,1968,47(4):1296-1302.  

[76] 陈秀丽,李连彬,岳洪源,等.裂殖壶菌粉对鸡蛋品质与蛋黄n-3 PUFA含量的影响[J].中国畜牧杂志,2014,50(23):66-70.

[77] AYMOND W M,VAN ELSWYK M E.Yolk thiobarbituric acid reactive substances and n-3 fatty acids in response to whole and ground flaxseed[J].Poultry Science,1995,74(8):1388-1394.  

[78] LEMAHIEU C,BRUNEEL C,TERMOTE-VERHALLE R,et al.Impact of feed supplementation with different omega-3 rich microalgae species on enrichment of eggs of laying hens[J].Food Chemistry,2013,141(4):4051-4059.  

[79] 杨蕊,SHIN J S,刘玉海,等.饲粮中添加微藻DHA和ALA对蛋黄脂肪酸构成及蛋黄胆固醇、三酰甘油的影响[J].饲料研究,2014(21):11-14,64.

[80] HAYAT Z,CHERIAN G,PASHA T N,et al.Oxidative stability and lipid components of eggs from flax-fed hens:effect of dietary antioxidants and storage[J].Poultry Science,2010,89(6):1285-1292.  

[81] KING E J,HUGO A,DE WITT F H,et al.Effect of dietary fat source on fatty acid profile and lipid oxidation of eggs[J].South African Journal of Animal Science,2012,42(5):503-506.

[82] AO T,MACALINTAL L M,PAUL M A,et al.Effects of supplementing microalgae in laying hen diets on productive performance,fatty-acid profile,and oxidative stability of eggs[J].Journal of Applied Poultry Research,2015,24(3):394-400.  

[83] CHANMUGAM P,BOUDREAU M,BOUTTE T,et al.Incorporation of different types of n-3 fatty acids into tissue lipids of poultry[J].Poultry Science,1992,71(3):516-521.  

[84] 邹彩霞.富含多不饱和脂肪酸和低胆固醇鸡肉的研究[D].硕士学位论文.南宁:广西大学,2002.

[85] HARGIS P S,VAN ELSWYK M E.Manipulating the fatty acid composition of poultry meat and eggs for the health conscious consumer[J].World's Poultry Science Journal,1993,49(3):251-264.  

[86] 李岩,孙超.日粮添加DHA对肉仔鸡生长及脂肪代谢基因转录的后效作用[J].中国农业科学,2009,42(11):4042-4050.

[87] SIMOPOULOS A P,LEAF A,SALEM N,Jr.Workshop on the essentiality of and recommended dietary intakes for omega-6 and omega-3 fatty acids[J].Journal of the American College of Nutrition,1999,18(5):487-489.  
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