综述 Review

维生素A对动物脂类代谢的调节作用与机制

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  • 内蒙古农业大学动物科学学院, 呼和浩特 010018
王雪(1992-),女,内蒙古呼伦贝尔人,博士研究生,从事动物营养与饲料领域研究。E-mail:wangxue199204@163.com

收稿日期: 2016-11-01

  网络出版日期: 2017-05-13

基金资助

国家公益性行业(农业)科研专项经费(201003061)

Regulatory Effects of Vitamin A on Lipid Metabolism of Animals and Its Mechanism

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  • College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China

Received date: 2016-11-01

  Online published: 2017-05-13

摘要

维生素A是影响动物组织脂类代谢的关键因子。本文综述了维生素A对动物脂类代谢的影响,并从脂类代谢相关基因的表达及其信号通路、脂肪细胞的数量、脂肪细胞因子分泌和参与表观遗传学修饰的角度综述了其可能的影响机制,为深入探讨维生素A对动物脂类代谢的影响机制及通过维生素A调控动物的脂肪代谢提供了理论依据。

本文引用格式

王雪, 闫素梅 . 维生素A对动物脂类代谢的调节作用与机制[J]. 动物营养学报, 2017 , 29(5) : 1462 -1468 . DOI: 10.3969/j.issn.1006-267x.2017.05.002

Abstract

Vitamin A is a key regulator influencing lipid metabolism in animal tissues. This review summarized the roles and probable regulatory mechanism of lipid metabolism regulated by vitamin A, which involves in gene expressions and signaling pathway related to lipid metabolism, adipocytes amount, secretory function of adipocytes and the role in epigenetic regulation, with the aim of providing theoretical basis for further study on the mechanism of effects of vitamin A on animal lipid metabolism, and regulating animal lipid metabolism by vitamin A.

参考文献

[1] AYUSO M,FERNÁNDEZ A,ISABEL B,et al.Long term vitamin a restriction improves meat quality parameters and modifies gene expression in Iberian pigs[J].Journal of Animal Science,2015,93(6):2730-2744.  

[2] FELIPE F,BONET M L,RIBOT J,et al.Modulation of resistin expression by retinoic acid and vitamin A status[J].Diabetes,2004,53(4):882-889.  

[3] JEYAKUMAR S M,SHERIL A,VAJRESWARI A.Chronic vitamin A-enriched diet feeding induces body weight gain and adiposity in lean and glucose-intolerant obese rats of WNIN/GR-Ob strain[J].Experimental Physiology,2015,100(11):1352-1361.  

[4] BERRY D C,NOY N.All-trans-retinoic acid represses obesity and insulin resistance by activating both peroxisome proliferation-activated receptor β/δ and retinoic acid receptor[J].Molecular and Cellular Biology,2009,29(12):3286-3296.  

[5] MURANO I,MORRONI M,ZINGARETTI M C,et al.Morphology of ferret subcutaneous adipose tissue after 6-month daily supplementation with oral beta-carotene[J].Biochimica et Biophysica Acta:Molecular Basis of Disease,2015,1740(2):305-312.

[6] SÁNCHEZ J,FUSTER A,OLIVER P,et al.Effects of β-carotene supplementation on adipose tissue thermogenic capacity in ferrets (Mustela putorius furo)[J].British Journal of Nutrition,2009,102(11):1686-1694.  

[7] YEHYA A,BAER J T,SMILEY W,et al.Hypervitaminosis A altering the lipid profile in a hypercholesterolemic patient[J].Journal of Clinical Lipidology,2009,3(3):205-207.  

[8] KHANNA A,REDDY T S.Effect of undernutrition and vitamin A deficiency on the phospholipid composition of rat tissues at 21 days of age-Ⅰ.Liver,spleen and kidney[J].International Journal for Vitamin and Nutrition Research,1983,53(1):3-8.

[9] CHEN W,CHEN G X.The roles of vitamin A in the regulation of carbohydrate,lipid,and protein metabolism[J].Journal of Clinical Medicine,2014,3(2):453-479.  

[10] TRIPATHY S,CHAPMAN J D,HAN C Y,et al.All-trans-retinoic acid enhances mitochondrial function in models of Human Liver[J].Molecular Pharmacology,2016,89(5):560-574.  

[11] OLIVEROS L B,DOMENICONI M A,VEGA V A,et al.Vitamin A deficiency modifies lipid metabolism in rat liver[J].British Journal of Nutrition,2007,97(2):263-272.  

[12] SOLOMON L W,ERDMAN J W, Jr.Vitamin A induced hypertriglyceridemia in cholesterol-fed rats[J].Lipids,1980,15(3):157-162.  

[13] PUIGSERVER P,VÁZQUEZ F,BONET M L,et al.In vitro and in vivo induction of brown adipocyte uncoupling protein (thermogenin) by retinoic acid[J].Biochemical Journal,1996,317(3):827-833.  

[14] FELIPE F,BONET M L,RIBOT J,et al.Up-regulation of muscle uncoupling protein 3 gene expression in mice following high fat diet,dietary vitamin A supplementation and acute retinoic acid-treatment[J].International Journal of Obesity,2003,27(1):60-69.  

[15] REPA J J,LIANG G S,OU J F,et al.Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors,LXRα and LXRβ[J].Genes and Development,2000,14(22):2819-2830.  

[16] YANG Q,GRAHAM T E,MODY N,et al.Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes[J].Nature,2005,436(7049):356-362.  

[17] YOSHIKAWA T,IDE T,SHIMANO H,et al.Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism.Ⅰ.PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling[J].Molecular Endocrinology,2003,17(7):1240-1254.  

[18] SHAW N,ELHOLM M,NOY N,et al.Retinoic acid is a high affinity selective ligand for the peroxisome proliferator-activated receptor α/β[J].Journal of Biological Chemistry,2003,278(43):41589-41592.  

[19] LUQUET S,GAUDEL C,HOLST D,et al.Roles of PPAR delta in lipid absorption and metabolism:a new target for the treatment of type 2 diabetes[J].Biochimica et Biophysica Acta:Molecular Basis of Disease,2005,1740(2):313-317.  

[20] TANG Q Q,ZHANG J W,LANE M D.Sequential gene promoter interactions of C/EBPbeta,C/EBPalpha,and PPARgamma during adipogenesis[J].Biochemical and Biophysical Research Communications,2004,319(1):235-239.  

[21] SCHWARZ E J,REGINATO M J,SHAO D,et al.Retinoic acid blocks adipogenesis by inhibiting C/EBPbeta-mediated transcription[J].Molecular and Cellular Biology,1997,17(3):1552-1561.  

[22] CADOUDAL T,GLORIAN M,MASSIAS A,et al.Retinoids upregulate phosphoenolpyruvate carboxykinase and glyceroneogenesis in human and rodent adipocytes[J].The Journal of Nutrition,2008,138(6):1004-1009.

[23] MILLER C W,WATERS K M,NTAMBI J M.Regulation of hepatic stearoyl-CoA desaturase gene 1 by vitamin A[J].Biochemical and Biophysical Research Communications,1997,231(1):206-210.  

[24] RAISHER B D,GULICK T,ZHANG Z,et al.Identification of a novel retinoid-responsive element in the promoter region of the medium chain acyl-coenzyme A dehydrogenase gene[J].Journal of Biological Chemistry,1992,267(28):20264-20269.

[25] VU-DAC N,GERVOIS P,TORRA I P,et al.Retinoids increase human apo C-Ⅲ expression at the transcriptional level via the retinoid X receptor[J].Journal of Clinical Investigation,1998,102(3):625-632.  

[26] TANIGUCHI D,MIZOGUCHI Y.Retinoic acids change gene expression profiles of bovine intramuscular adipocyte differentiation,based on microarray analysis[J].Animal Science Journal,2015,86(6):579-587.  

[27] BERRY D C,JIN H,MAJUMDAR A,et al.Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses[J].Proceedings of the National Academy of Sciences of the United States of America,2011,108(11):4340-4345.  

[28] KANG H W,BHIMIDI G R,ODOM D P,et al.Altered lipid catabolism in the vitamin A deficient liver[J].Molecular and Cellular Endocrinology,2007,271(1/2):18-27.

[29] XIONG Y,COLLINS Q F,AN J,et al.p38 mitogen-activated protein kinase plays an inhibitory role in hepatic lipogenesis[J].Journal of Biological Chemistry,2007,282(7):4975-4982.  

[30] BARGER P M,BROWNING A C,GARNER A N,et al.p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor α:a potential role in the cardiac metabolic stress response[J].Journal of Biological Chemistry,2001,276(48):44495-44501.  

[31] 刘洋.ATRA调控BMP9诱导3T3-L1前脂肪细胞成骨和成脂分化的作用及机制研究[D].博士学位论文.重庆:重庆医科大学,2014.

[32] KIM D M,CHOI H R,PARK A,et al.Retinoic acid inhibits adipogenesis via activation of Wnt signaling pathway in 3T3-L1 preadipocytes[J].Biochemical and Biophysical Research Communications,2013,434(3):455-459.  

[33] TAKADA I,MIHARA M,SUZAWA M,et al.A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-γ transactivation[J].Nature Cell Biology,2007,9(11):1273-1285.  

[34] OSEI-SARFO K,GUDAS L J.Retinoic acid suppresses the canonical Wnt signaling pathway in embryonic stem cells and activates the noncanonical Wnt signaling pathway[J].Stem Cells,2014,32(8):2061-2071.  

[35] HISADA K,HATA K,ICHIDA F,et al.Retinoic acid regulates commitment of undifferentiated mesenchymal stem cells into osteoblasts and adipocytes[J].Journal of Bone & Mineral Metabolism,2013,31(1):53-63.  

[36] MARCHILDON F,ST-LOUIS C,AKTER R,et al.Transcription factor Smad3 is required for the inhibition of adipogenesis by retinoic acid[J].Journal of Biological Chemistry,2010,285(17):13274-13284.  

[37] STEPPAN C M,BAILEY S T,BHAT S,et al.The hormone resistin links obesity to diabetes[J].Nature,2001,409(6818):307-312.  

[38] HOLLUNG K,RISE C P,DREVON C A,et al.Tissue-specific regulation of leptin expression and secretion by all-trans retinoic acid[J].Journal of Cellular Biochemistry,2004,92(2):307-315.  

[39] SONG H Y,SHOJIMA N,Sakoda H,et al.Resistin is regulated by C/EBPs,PPARs,and signal-transducing molecules[J].Biochemical and Biophysical Research Communications,2002,299(2):291-298.  

[40] HUANG Y,DAS A K,YANG Q Y,et al.Zfp423 promotes adipogenic differentiation of bovine stromal vascular cells[J].PLoS One,2012,7(10):e47496.

[41] WANG B,YANG Q Y,HARRIS C L,et al.Nutrigenomic regulation of adipose tissue development-role of retinoic acid:a review[J].Meat Science,2016,120:100-106.
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