[1] HOLTKAMP D J,KLIEBENSTEIN J B,NEUMANN E J,et al.Assessment of the economic impact of porcine reproductive and respiratory syndrome virus on U.S. pork producers[J].Journal of Swine Health & Production,2013,21(2):72-84.
[2] SALAMA S S.Preliminary Study on Bacterial Strains Used in the Preparation of Polyvalent Inactivated Vaccine Against Chronic Respiratory Disease in Chickens[J].Global Veterinaria, 2015,14(3):287-291.
[3] LOW D.Reducing antibiotic use in influenza:challenges and rewards[J].Clinical Microbiology and Infection,2008,14(4):298-306.

[4] 魏刚才,郑爱武.家禽的第一道防范病原微生物入侵的屏障--黏膜系统的""护卫""组合性功能[J].中国动物保健,2008,6:79-83.
[5] NIKITAS G,COSSART P.Adherens junctions and pathogen entry[J].Sub-Cellular Biochemistry,2012,60:415-425.
[6] 吴晓东,施毅.气道防御屏障[J].中国呼吸与危重监护杂志,2011,10(3):301-304.
[7] 游曼清,王宋平.气道上皮屏障在支气管哮喘防御机制中的研究进展[J].国际呼吸杂志,2013,33(17):29-33.
[8] CRYSTAL R G,RANDELL S H,ENGELHARDT J F,et al.Airway epithelial cells:current concepts and challenges[J].Proceedings of the American Thoracic Society,2008,5(7):772-7.

[9] GANESAN S,COMSTOCK A T,SAJJAN U S.Barrier function of airway tract epithelium[J].Tissue Barriers,2013,1(4):e24997-e24997.
[10] 魏刚才,梁秀荣,郑爱武.呼吸道黏膜保护与鸡新城疫的控制[J].养禽与禽病防治,2008,06:9-11.
[11] BARTLETT J,FISCHER A,MCCRAY P B Jr.Innate Immune Functions of the Airway Epithelium[J].Contributions to Microbiology,2008,15:147-63.
[12] RANDELL S H.Airway Epithelial Stem Cells and the Pathophysiology of Chronic Obstructive Pulmonary Disease[J].Proceedings of the American Thoracic Society,2006,3(8):718-25.

[13] DAVID P,RICHARD L.Epithelial cells and airway diseases[J].Immunological Reviews,2011,242(1):186-204.

[14] 黄武锋.高迁移率族蛋白1(HMGB1)对气道上皮屏障功能失调的机制研究[D].博士学位论文.广州:南方医科大学,2014.
[15] 吴晓东,施毅.气道防御屏障[J].中国呼吸与危重监护杂志,2011,10(3):301-304.
[16] PEREZMORENO M,FUCHS E.Catenins:keeping cells from getting their signals crossed[J].Developmental Cell,2006,11(5):601-612.

[17] 纪笑英.Th2/Th17偏转微环境对人支气管上皮细胞重塑的作用及其机制研究[D].博士学位论文.长沙:中南大学,2013.
[18] 呙于明,刘丹,张炳坤.家禽肠道屏障功能及其营养调控[J].动物营养学报,2014,26(10):3091-3100.
[19] 游曼清,王宋平.气道上皮屏障在支气管哮喘防御机制中的研究进展[J].中华哮喘杂志:电子版,2013,7(5):29-33.
[20] KAST J I,WANKE K,SOYKA M B,et al.The broad spectrum of interepithelial junctions in skin and lung[J].Journal of Allergy & Clinical Immunology,2012,130(2):544-547.

[21] 段甦,矫健,张罗.组胺对呼吸道上皮紧密连接表达的影响[J].中国耳鼻咽喉头颈外科,2015,22(8):426-430.
[22] 游曼清.布地奈德对哮喘小鼠气道上皮occludin和E-cadherin表达的影响[D].硕士学位论文.泸州:泸州医学院,2014.
[23] SAWADA N.Tight junction-related human diseases[J].Pathology International,2013,63(1):1-12.

[24] 车东升,潘丽,钟荣珍,等.闭合蛋白:结构、功能及其相关调节机制[J].动物营养学报,2013,25(12):2783-2789.
[25] BERKES J,VISWANATHAN V K,SAVKOVIC S D,et al.Intestinal epithelial responses to enteric pathogens:effects on the tight junction barrier,ion transport,and inflammation[J].Gut,2003,52(3):439-451.

[26] 邢晓辉,李力仙,郭天林,等.Claudin蛋白在紧密连接中的作用机制及与疾病的关系[J].中华临床医师杂志:电子版,2013,7(23):229-231.
[27] GEORAS S N,REZAEE F.Epithelial barrier function:At the front line of asthma immunology and allergic airway inflammation[J].Journal of Allergy & Clinical Immunology,2014,134(3):509-520.

[28] AUVYNET C,ROSENSTEIN Y.Multifunctional host defense peptides:antimicrobial peptides,the small yet big players in innate and adaptive immunity[J].Febs Journal,2009,276(22):6497-6508.

[29] LINDEN S K,SUTTON P,KARLSSON N G,et al.Mucins in the mucosal barrier to infection[J].Pragmalinguistica,2008,1(3):183-197.
[30] THORNTON D J,ROUSSEAU K,MCGUCKIN M A.Structure and function of the polymeric mucins in airways mucus[J].Physiology,2008,70(1):459-486.

[31] JOHNSON D C.Airway mucus function and dysfunction[J].New England Journal of Medicine,2011,364(10):2233-2247.
[32] 强丽霞,石昭泉.MUC5AC与气道黏液高分泌[J].国际呼吸杂志,2011,31(5):385-387.
[33] ROSE M C,NICKOLA T J,VOYNOW J A.Airway mucus obstruction:mucin glycoproteins,
MUC gene regulation and goblet cell hyperplasia[J].American Journal of Respiratory Cell & Molecular Biology,2001,25(5):533-537.

[34] SOHAIL M U,HUME M E,BYRD J A,et al.Molecular analysis of the caecal and tracheal microbiome of heat-stressed broilers supplemented with prebiotic and probiotic[J].Avian Pathology Journal of the W.V.P.A,2015,44(2):67-74.

[35] 孙春阳.复合芽孢杆菌喷剂对鸡舍环境及肉鸡呼吸道菌群结构的影响[D].硕士学位论文.北京:中国农业科学院,2014.
[36] 潘康成,古从伟,杨晓尧,等.枯草芽孢杆菌Pab02喷雾剂对肉鸡呼吸道菌群的影响[J].中国兽医学报,2012,32(3):387-392.
[37] 栾素军.芽孢杆菌喷雾制剂对鸡舍环境及肉鸡呼吸道黏膜屏障的影响[D].硕士学位论文.北京:中国农业科学院,2016.
[38] RANGEL-MORENO J,CARRAGHER D,RANDALL T D.Role of lymphotoxin and homeostatic chemokines in the development and function of local lymphoid tissues in the respiratory tract[J].Inmunologia,2007,26(1):13-28.
[39] TANGO M,SUZUKI E,GEJYO F,et al.The presence of specialized epithelial cells on the bronchus-associated lymphoid tissue (BALT) in the mouse[J].Archives of Histology & Cytology,2000,63(1):81-9.

[40] 雷娜,李娴,林青.sIgA在呼吸道黏膜免疫中的作用[C]//世界中医药学会联合会首届中医全球化与人类健康高峰论坛.昆明:世界中医药学会联合会,2011:303-310.
[41] 杨树宝.鸡呼吸道相关性淋巴组织发育及其免疫功能发生的研究[D].博士学位论文.长春:吉林农业大学,2014.
[42] 闫梦菲,康海泓,杨倩.鸡鼻腔组织学特点及鼻相关淋巴组织分布的研究[J].畜牧兽医学报,2014,45(12):2043-2049.
[43] 冯小刚.鸡鼻相关淋巴组织的发育和功能建立[D].硕士学位论文.长春:吉林农业大学,2013.
[44] 王悦芸,刘琪,安欣宇,等.黏膜免疫系统及黏膜免疫研究进展[J].畜牧与兽医,2015,47(7):116-119.
[45] 吕茂杰,梁武,何召庆,等.动物黏膜免疫系统的研究进展[J].黑龙江畜牧兽医,2013,15:36-39.
[46] 张蕊,高雪丽,郑世民.家禽黏膜免疫系统与疫苗免疫[J].中国家禽,2012,34(16):46-48.
[47] PETERSON D A,MCNULTY N P,GURUGE J L,et al.IgA Response to symbiotic bacteria as a mediator of gut homeostasis[J].Cell Host & Microbe,2007,2(5):328-339.

[48] MACPHERSON A J,HUNZIKER L,MCCOY K,et al.IgA responses in the intestinal mucosa against pathogenic and non-pathogenic microorganisms[J].Microbes & Infection,2001,3(12):1021-1035.

[49] SAINI M S,LIBERATI D M,DIEBEL L N.Sequential changes in mucosal immunity after hemorrhagic shock[J].American Surgeon,2001,67(8):797-801.
[50] 李鹏成,刘志学,高君恺,等.猪呼吸道IgA和IgG分泌细胞的分布[J].畜牧兽医学报,2010,41(7):873-877.
[51] 蔡晓华,王全溪.呼吸道黏膜免疫的综述[C]//福建省畜牧兽医学会畜禽传染病防治专业委员会猪病学术研讨会.福清:福建省畜牧兽医学会,2009:160-163.
[52] SATO S,KIYONO H.The mucosal immune system of the respiratory tract[J].Current Opinion in Virology,2012,2(3):225-232.

[53] MCCORMICK S,SHALER C R,XING Z.Pulmonary mucosal dendritic cells in T-cell activation:implications for TB therapy[J].Expert Review of Respiratory Medicine,2011,5(1):75-85.

[54] 来薛,赵丹,俞庆声,等.中医药对呼吸道黏膜免疫影响的研究进展[J].中华中医药杂志,2013,1:164-167.
[55] 吴高慧,李超乾.呼吸道黏膜免疫的研究进展[J].国际呼吸杂志,2007,27(22):1711-1714.
[56] KNIGHT D A,HOLGATE S T.The airway epithelium:Structural and functional properties in health and disease[J].Respirology,2003,8(4):432-446.

[57] REGUEIRO V,MORANTA DCAMPOS M A.Klebsiella pneumoniae increases the levels of Toll-like receptors 2 and 4 in human airway epithelial cells[J].Infection & Immunity,2009,77(2):714-24.

[58] 李聪.不同浓度氨气对肉鸡生长性能及呼吸道黏膜屏障的影响[D].硕士学位论文.北京:中国农业科学院,2014.
[59] 范肖肖.日粮维生素A添加水平与应激对肉仔鸡呼吸道黏膜免疫的影响[D].硕士学位论文.泰安:山东农业大学,2015.
[60] FAN X,LIU S,LIU G,et al.Vitamin A deficiency impairs mucin expression and suppresses the mucosal immune function of the respiratory tract in chicks[J].Plos One,2015,10(9):e0139131.
[61] 艾琳,李学民,刘文华,等.维生素A对家禽呼吸道黏膜的调节作用[J].中国家禽,2013,35(24):54-55.
[62] 郭超.维生素A与慢性阻塞性肺疾病[J].中国临床研究,2008,21(1):102-103.
[63] 王迪.乳酸菌调节的雏鸡呼吸道菌群变化及免疫调节作用研究[D].硕士学位论文.长春:吉林农业大学,2015.
[64] 魏刚才,陈永耀,齐红霞.家禽呼吸道黏膜保护措施[J].中国家禽,2006,28(1):31-32.
[65] 杨倩,庾庆华,李玉磊.猪呼吸道淋巴组织发育的亚显微结构变化[J].畜牧兽医学报,2006,37(4):374-378.
[66] 李云锋,王建美,李鹏成,等.猪肺炎支原体弱毒株与佐剂配合鼻腔免疫对仔猪呼吸道抗体分泌细胞的影响[J].南京农业大学学报,2013,36(1):103-107.
[67] 张鉴日,张福亮.维护呼吸道黏膜完整的措施[J].中国畜禽种业,2010,6(9):149-150.
[68] 龚大春.鸡呼吸道正常菌丛对抗菌药物敏感性的研究[J].长江大学学报:自科版,2014,(23):30-32.