李瑞, 侯改凤, 韦良开, 彭伟, 潘杰, 黄兴国 . 德氏乳杆菌对育肥猪血脂指标、胆固醇代谢和脂肪沉积相关酶活性及基因mRNA表达的影响[J]. 动物营养学报, 2017 , 29(9) : 3184 -3192 . DOI: 10.3969/j.issn.1006-267x.2017.09.021

[1] PARRA V,PETRÓN M J,MARTÍN L,et al.Modification of the fat composition of the Iberian pig using Bacillus licheniformis and Bacillus subtilis[J].European Journal of Lipid Science and Technology,2010,112(7):720-726.  

[2] LI C,NIE S P,DING Q,et al.Cholesterol-lowering effect of Lactobacillus plantarum NCU116 in a hyperlipidaemic rat model[J].Journal of Functional Foods,2014,8:340-347.

[3] NUERNBERG K,FISCHER K,NUERNBERG G,et al.Effects of dietary olive and linseed oil on lipid composition,meat quality,sensory characteristics and muscle structure in pigs[J].Meat Science,2005,70(1):63-74.  

[4] WOOD J D,ENSER M,NUTE A V,et al.Fat deposition,fatty acid composition and meat quality:a review[J].Meat Science,2008,78(4):343-358.  

[5] GUILLEVIC M,KOUBA M,MOUROT J.Effect of a linseed diet or a sunflower diet on performances,fatty acid composition,lipogenic enzyme activities and stearoyl-CoA-desaturase activity in pig[J].Livestock Science,2009,124(1/2/3):288-294.

[6] FUENTES M C,LAJO T,CARRIÓN J M,et al.Cholesterol-lowering efficacy of Lactobacillus plantarum CECT 7527,7528 and 7529 in hypercholesterolaemic adults[J].British Journal of Nutrition,2013,109(10):1866-1872.  

[7] 李瑞.德氏乳杆菌对育肥猪胆固醇代谢的影响研究[D].硕士学位论文.长沙:湖南农业大学,2014.

[8] 侯改凤.德氏乳杆菌对育肥猪生长性能、猪肉品质及脂肪沉积影响研究[D].硕士学位论文.长沙:湖南农业大学,2015.

[9] 杨公社.猪生产学[M].北京:中国农业出版社,2002:234-236.

[10] 李瑞,侯改凤,刘明,等.德氏乳杆菌对育肥猪生产性能、血脂指标及粪和组织中总胆固醇和总胆汁酸含量的影响[J].动物营养学报,2015,27(1):247-255.

[11] MEUNIER A,LALANNE F,NICOLLE C,et al.Blood-cholesterol-lowering strain of Lactobacillus delbrueckii:United States Patent 8652461[P].2014-02-18.

[12] SONG M,PARK S,LEE H,et al.Effect of Lactobacillus acidophilus NS1 on plasma cholesterol levels in diet-induced obese mice[J].Journal of Dairy Science,2015,98(3):1492-1501.  

[13] 张董燕,季海峰,王四新,等.猪源唾液乳杆菌对生长猪生长性能、粪中微生物数量及血清指标的影响[J].动物营养学报,2014,26(3):725-731.

[14] 张剑峰.牛磺酸、低聚木糖和益生菌对蛋鸡生产及胆固醇沉积的影响[D].硕士学位论文.南京:南京农业大学,2011.

[15] 谢宁.两株乳酸杆菌对高脂饮食大鼠胆固醇影响及相关机制研究[D].博士学位论文.长沙:中南大学,2011.

[16] HOSOMI R,FUKUNAGA K,ARAI H,et al.Effects of dietary fish protein on serum and liver lipid concentrations in rats and the expression of hepatic genes involved in lipid metabolism[J].Journal of Agricultural and Food Chemistry,2009,57(19):9256-9262.  

[17] GILARDI F,MITRO N,GODIO C,et al.The pharmacological exploitation of cholesterol 7α-hydroxylase,the key enzyme in bile acid sythesis:from binding resins to chromatin remodelling to reduce plasma cholesterol[J].Pharmacol Therapeut,2007,116(3):449-472.  

[18] 廖端芳,唐朝克.胆固醇逆向转运基础与临床[M].北京:科学出版社,2009:19-20.

[19] GOLDBERG I J,ECJEL R H,ABUMRAD N A.Regulation of fatty acid uptake into tissues:lipoprotein lipase-and CD36-mediated pathways[J].Journal of Lipid Research,2008,50(Suppl.1):S86-S90.

[20] FRVHBECK G,MÉNDEZ-GIMÉNEZ L,FERNÁNDEZ-FORMOSO J A,et al.Regulation of adipocyte lipolysis[J].Nutrition Research Reviews,2014,27(1):63-93.  

[21] 张明明,宋光耀.高胆固醇血症低密度脂蛋白受体基因突变的研究进展[J].河北医科大学学报,2011,32(7):866-868.

[22] ABISAMBRA J F,FIORELI T,PADMANABHAN J,et al.LDLR expression and localization are altered in mouse and human cell culture models of alzheimer's Disease[J].PLoS One,2010,5(1):e8556.

[23] KULSETH M A,BERGE K E,BOGSRUD M P,et al.Analysis of LDLR mRNA in patients with familial hypercholesterolemia revealed a novel mutation in intron 14,which activates a cryptic splice site[J].Journal of Human Genetics,2010,55(10):676-680.  

[24] KRAUSE B R,AUERBACH B J.Reverse cholesterol transport and future pharmacological approaches to the treatment of atherosclerosis[J].Current Opinion in Investigational Drugs,2001,2(3):375-381.

[25] 张慧平,孙福成,王抒.高密度脂蛋白与动脉粥样硬化和冠心病[J].中国动脉硬化杂志,2004,12(6):733-736.

[26] WONG M H,OELKERS P,DAWSON P A.Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity[J].Journal of Biological Chemistry,1995,270(45):27228-27234.  

[27] CHEN F,MA L,AL-ANSARI N,et al.The role of AP-1 in the transcriptional regulation of the rat apical sodium-dependent bile acid transporter[J].Journal of Biological Chemistry,2001,276(42):38703-38714.  

[28] SHNEIDER B L,DAWSON P A,CHRISTIE D M,et al.Cloning and molecular characterization of the ontogeny of a rat ileal sodium-dependent bile acid transporter[J].Journal of Clinical Investigation,1995,95(4):745-754.

[29] XU G,SHNEIDER B L,SHEFER S,et al.Ileal bile acid transport regulates bile acid pool,synthesis,and plasma cholesterol levels differently in cholesterol-fed rats and rabbits[J].Journal of Lipid Research,2000,41(2):298-304.

[30] DE RODAS B Z,GILLILAND S E,MAXWELL C V.Hypocholesterolemic action of Lactobacillus acidophilus ATCC 43121 and calcium in swine with hypercholesterolemia induced by diet[J].Journal of Dairy Science,1996,79(12):2121-2128.  

[31] FORETZ M,GUICHARD P,FERR P.Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes[J].Proceedings of the National Academy of Sciences of the United States of America,1999,96(22):12737-12742.  

[32] XU C,WANG L L,LIU H Y,et al.A novel dual peroxisome proliferator-activated receptors α and γ agonist with beneficial effects on insulin resistance and lipid metabolism[J].Biotechnology Letters,2006,28(12):863-868.  

[33] 宋冰,刘学政.大黄素对KKAy糖尿病小鼠脂肪组织PPAY-α及PPAY-γ表达影响的实验研究[J].北京中医药大学学报,2012,35(10):692-695.

[34] 段颖,郭翔宇,孙文,等.番石榴叶提取物调节小鼠脂肪组织TNF-α、PPAR-γ基因表达改善肝脏糖调节机制研究[J].中华中医药杂志,2014,29(5):1622-1625.