综述 Review

固有免疫相关模式识别受体研究进展

展开
  • 湖南农业大学动物科学技术学院, 长沙 410128
何邵平(1990-),男,湖南邵阳人,博士研究生,从事动物营养与免疫调控相关研究。E-mail:heshaoping56778@163.com

收稿日期: 2017-05-18

  网络出版日期: 2017-10-31

基金资助

国家自然科学基金面上项目(31672444)

Research Advancement of Innate Immunity and Pattern Recognition Receptors

Expand
  • College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China

Received date: 2017-05-18

  Online published: 2017-10-31

摘要

固有免疫是机体免疫系统防御微生物感染的第1道防线。模式识别受体(PRRs)中的Toll样受体(TLRs)、核苷酸寡聚结合域样受体(NLRs)和视黄酸诱导基因1样受体(RLRs)等识别不同或重叠的微生物组成成分,形成相应的信号转导产生免疫应答。近些年对于固有免疫相关PRRs的研究也取得了较大的进展,为免疫相关疾病的治疗提供了思路。本文对固有免疫相关PRRs的特征及不同PRRs的信号传导途径之间相互作用进行综述。

本文引用格式

何邵平, 贺建华, 陈佳亿, 陈福, 欧淑琦 . 固有免疫相关模式识别受体研究进展[J]. 动物营养学报, 2017 , 29(11) : 3844 -3851 . DOI: 10.3969/j.issn.1006-267x.2017.11.002

Abstract

Innate immunity is the first defense against the pathogen aggression. Toll-like receptors (TLRs), nucleotide-binding oligomerization domain-like receptors (NLRs) and RIG-1-like receptors (RLRs) serve as pattern recognition receptors (PRRs) that recognize different but overlapping microbial components, formation of the corresponding signal transduction to generate immune response. The study on innate immunity and PRRs has received grade advancement in recent years that provides a way for the treatment of immune related diseases. This review summarized characteristics of PRRs and the interplay across different PRR signaling pathways.

参考文献

[1] JANEWAY C J.Approaching the asymptote? Evolution and revolution in immunology[J].Cold Spring Harbor Symposia on Quantitative Biology,1989,54:1-13.

[2] AKIRA S,UEMATSU S,TAKEUCHI O.Pathogen recognition and innate immunity[J].Cell,2006, 124(4):783-801.  

[3] BARTON G M,KAGAN J C.A cell biological view of Toll-like receptor function:regulation through compartmentalization[J].Nature Reviews Immunology,2009,9(8):535-542.  

[4] IWASAKI A,MEDZHITOV R.Control of adaptive immunity by the innate immune system[J].Nature Immunology,2015,16(4):343-353.  

[5] DINARELLO C A.Inflammatory cytokines:interleukin-1 and tumor necrosis factor as effector molecules in autoimmune diseases[J].Current Opinion in Immunology,1991,3(6):941-948.  

[6] GAY N J,KEITH F J.Drosophila Toll and IL-1 receptor[J].Nature,1991,351(6325):355-356.

[7] HEGUY A,BALDARI C T,MACCHIA G,et al.Amino acids conserved in interleukin-1 receptors (IL-1Rs) and the Drosophila toll protein are essential for IL-1R signal transduction[J].Journal of Biological Chemistry,1992,267(4):2605-2609.

[8] POLTORAK A,HE X,SMIRNOVA I,et al.Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice:mutations in TLR4 gene[J].Science,1998,282(5396):2085-2088.  

[9] QURESHI S T,LARIVIERE L,LEVEQUE G,et al.Endotoxin-tolerant mice have mutations in Toll-like receptor 4(TLR4)[J].Journal of Experimental Medicine,1999,189(4):615-625.  

[10] HOSHINO K,TAKEUCHI O,KAWAI T,et al.Cutting edge:Toll-like receptor 4(TLR4)-deficient mice are hyporesponsive to lipopolysaccharide:evidence for TLR4 as the Lps gene product[J].Journal of Immunology,1999,162(7):3749-3752.

[11] KAWAI T,AKIRA S.The roles of TLRs,RLRs and NLRs in pathogen recognition[J].International Immunology,2009,21(4):17-337.

[12] JIN M S,KIM S E,HEO J Y,et al.Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide[J].Cell,2007,130(6):1071-1082.  

[13] HAYASHI F,SMITH K D,OZINSKY A,et al.The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5[J].Nature,2001,410(6832):1099-1103.  

[14] UEMATSU S,FUJIMOTO K,JANG M H,et al.Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5[J].Nature Immunology,2008,9(7):769-776.  

[15] ZHANG D,ZHANG G,HAYDEN M S,et al.A Toll-like receptor that prevents infection by uropathogenic bacteria[J].Science,2004,303(5663):1522-1526.  

[16] ANDRADE W A,SOUZA M C,RAMOS-MARTINEZ E,et al.Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice[J].Cell Host Microbe,2013,13(1):42-53.  

[17] OLDENBURG M,KRUGER A,FERSTL R,et al.TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification[J].Science,2012,337(6098):1111-1115.  

[18] ALEXOPOULOU L,HOLT A C,MEDZHITOV R,et al.Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3[J].Nature,2001,413(6857):732-738.  

[19] LUND J,SATO A,AKIRA S,et al.Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells[J].Journal of Experimental Medicine,2003,198(3):513-520.  

[20] VOLLMER J,TLUK S,SCHMITZ C,et al.Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8[J].Journal of Experimental Medicine,2005,202(11):1575-1585.  

[21] FLANNERY S,BOWIE A G.The interleukin-1 receptor-associated kinases:critical regulators of innate immune signalling[J].Biochemical Pharmacology,2010,80(12):1981-1991.  

[22] KAWAI T,TAKEUCHI O,FUJITA T,et al.Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes[J].Journal of Immunology,2001,167(10):5887-5894.  

[23] HORNG T,BARTON G M,FLAVELL R A,et al.The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors[J].Nature,2002,420(6913):329-333.  

[24] OSHIUMI H,SASAI M,SHIDA K,et al.TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to Toll-like receptor 4 TICAM-1 that induces interferon-beta[J].Journal of Biological Chemistry,2003,278(50):49751-49762.  

[25] TING J P,LOVERING R C,ALNEMRI E S,et al.The NLR gene family:a standard nomenclature[J].Immunity,2008,28(3):285-287.  

[26] KANNEGANTI T D,LAMKANFI M,NUNEZ G.Intracellular NOD-like receptors in host defense and disease[J].Immunity,2007,27(4):549-559.  

[27] TRAVASSOS L H,CARNEIRO L A,RAMJEET M,et al.Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry[J].Nature Immunology,2010, 11(1):55-62.  

[28] SABBAH A,CHANG T H,HARNACK R,et al.Activation of innate immune antiviral responses by Nod2[J].Nature Immunology,2009,10(10):1073-1080.  

[29] ARNOULT D,SOARES F,TATTOLI I,et al.An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix[J].Journal of Cell Science,2009,122(17):3161-3168.  

[30] BRUBAKER S W,BONHAM K S,ZANONI I,et al.Innate immune pattern recognition:a cell biological perspective[J].Annual Review of Immunology,2015,33:257-290.

[31] CAO X.Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease[J].Nature Reviews Immunology,2015,16(1):35-50.  

[32] KATO H,TAKEUCHI O,SATO S,et al.Differential roles of MDA5 and RIG-Ⅰ helicases in the recognition of RNA viruses[J].Nature,2006,441(7089):101-105.  

[33] VENKATARAMAN T,VALDES M,ELSBY R,et al.Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses[J].Journal of Immunology,2007,178(10):6444-6455.  

[34] ZELENSKY A N,GREADY J E.The C-type lectin-like domain superfamily[J].Federation of European Biochemical Societies,2005, 272(24):6179-6217.

[35] HOVING J C,WILSON G J,BROWN G D.Signalling C-type lectin receptors, microbial recognition and immunity[J].Cellular Microbiology,2014,16(2):185-194.  

[36] SAIJO S,IKEDA S,YAMABE K,et al.Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans[J].Immunity,2010,32(5):681-691.  

[37] LAMKANFI M,DIXIT V M.Mechanisms and functions of inflammasomes[J].Cell,2014,157(5):1013-1022.  

[38] LI T,DINER B A,CHEN J,et al.Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16[J].Proceedings of the National Academy of Sciences,2012,109(26):10558-10563.  

[39] SHI J,ZHAO Y,WANG Y,et al.Inflammatory caspases are innate immune receptors for intracellular LPS[J].Nature,2014,514(7521):187-192.

[40] NEGISHI H,YANAI H,NAKAJIMA A,et al.Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses[J].Nature Immunology,2012,13(7):659-666.  

[41] FORSBACH A,MULLER C,MONTINO C,et al.Negative regulation of the type Ⅰ interferon signaling pathway by synthetic Toll-like receptor 7 ligands[J].Journal of Interferon and Cytokine Research,2012,32(6):254-268.  

[42] HENAO-MEJIA J,ELINAV E,STROWIG T,et al.Inflammasomes:far beyond inflammation[J].Nature Immunology,2012,13(4):321-324.  

[43] LIU J,CAO X.Cellular and molecular regulation of innate inflammatory responses[J].Cellular and Molecular Immunology,2016,13(6):711-721.  
文章导航

/