综述 Review

蛋氨酸在动物体内代谢途径与周转机制

展开
  • 扬州大学动物科学与技术学院, 扬州 225009
徐巧云(1993-),女,江苏扬州人,硕士研究生,动物营养与饲料科学专业。E-mail:1172270605@99.com

收稿日期: 2017-05-20

  网络出版日期: 2017-10-31

基金资助

国家自然科学基金面上项目(31672446);杨胜先生门生社群面上项目(2016A20031);江苏省优势学科(PAPD)

Metabolic Pathway and Turnover Mechanism of Methionine in Animals

Expand
  • College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China

Received date: 2017-05-20

  Online published: 2017-10-31

摘要

蛋氨酸(Met)是动物机体的必需氨基酸,可作为合成蛋白质的底物,也是机体代谢重要的甲基和巯基供体,同时还参与多胺的形成。为此,Met的供应状况以及其在体内的代谢途径影响着机体的生长性能、生理活动,乃至于DNA和功能蛋白质的甲基化修饰,进而影响机体正常的生命活动。本文就Met的4种代谢通路及其相应的周转机制进行综述,以期为Met代谢机理研究和合理科学应用提供参考。

本文引用格式

徐巧云, 胡良宇, 王梦芝 . 蛋氨酸在动物体内代谢途径与周转机制[J]. 动物营养学报, 2017 , 29(11) : 3877 -3884 . DOI: 10.3969/j.issn.1006-267x.2017.11.006

Abstract

As one of the essential amino acids, methionine (Met) is used to synthesize protein as substrate, and to provide important methyl and mercapto for animal metabolism; at the same time, it is also closely involved in the formation of polyamines. For this purpose, the supply and metabolic pathway of methionine in animal body would affect the growth performance, physiological activity, methylation modification of DNA and functional proteins further have an influence on animal normal life activities. This paper summarized recent researches on 4 kinds of metabolic pathways and related turnover mechanism of methionine to provide some information for the studies of methionine metabolic mechanisms and scientific application.

参考文献

[1] LU S C.S-Adenosylmethionine[J].The International Journal of Biochemistry & Cell Biology,2000,32(4):391-395.  

[2] ZEISEL S H.Choline:critical role during fetal development and dietary requirements in adults[J].Annual Review of Nutrition,2006,26(1):229-250.  

[3] 胡诚军,江青艳,孔祥峰.畜禽蛋氨酸代谢及其生理功能研究进展[J].饲料工业,2016,37(15):23-27.

[4] LEVINE R L,MOSKOVITZ J,STADTMAN E R.Oxidation of methionine in proteins:roles in antioxidant defense and cellular regulation[J].IUBMB Life,2000,50(4/5):301-307.

[5] LU S C,MATO J M.S-adenosylmethionine in liver health,injury,and cancer[J].Physiolo cal Reviews,2012,92(4):1515-1542.  

[6] WU G.Dietary requirements of synthesizable amino acids by animals:a paradigm shift in protein nutrition[J].Journal of Animal Science and Biotechnology,2014,5:34.

[7] KLEMESRUD M J, KLOPFENSTEIN T J, LEWIS A J. Metabolize methionine and lysine require ments of growing cattle[J].Journal Animal Science,2000,78(1):199-206.  

[8] NRC. Nutrient requirements of dairy cattle[S].Seventh Revised Edition.Washington,D.C.:The National Academies Press,2001.

[9] SAKI A A,NASERI HARSINI R,TABATABACI M M,et al.Estimates of methionine and sulfur amino acid requirements for laying hens using different models[J].Revista Brasileira De Ciência Avícola,2012,14(3):209-216

[10] BARTSOCAS C S,THIER S O,CRAWFORD J D.Transport of L-methionine in rat intestine and kidney[J].Pediatric Research,1974,8(6):673-678.  

[11] TAUTT J.Transport of methionine by normal and transformed rat embryo fibrobla[J]. Acta Biochimica Polonica,1982,29(3/4):213-218.

[12] PÉNZES L,SIMON G.Intestinal absorption and turnover of DL-methionine during reproduction in the rat[J].Journal of Physiological Anthropology,1968,18(3):288-296.

[13] BROSNAN J T,BROSNAN M E.The sulfur-containing amino acids:an overview[J].Journal of Nutrition,2006,136(6):1636S-1640S.

[14] LODISH H,BERK A J,ZIPURSKY S L,et al.The three roles of RNA in protein synt-hesis[M]//FREEMAN W H,et al.Laboratory notebook.New York:Molecular Cell Biology Press,2000.

[15] LIU S M,TAVENDALE M,BERMINGHAM E N,et al.The effects of parasite infection on methionine metabolism in sheep[J].Proceedings of the Australian Society of Animal Production,2002,24:133-136.

[16] CAREW L B,EVARTS K G,ALSTER F A.Growth and plasma thyroid hormone concentrations of chicks fed diets deficient in essential amino acids[J].Poultry Science,1997,76(10):1398-1404.  

[17] CAREW L B,MCMURTRY J P,ALSTER F A.Effects of methionine deficiencies on plasma levels of thyroid hormones, insulin-like growth factors Ⅰ and Ⅱ,liver and bady weights, and feed intake in growing chickens[J].Poultry Science,2003,82(12):1932-1938.  

[18] SCHICK B P.Synthesis of proteins from[35S]methionine by guinea pig megakaryoc ytes in vivo and time course of appearance of newly synthesized proteins in platelets[J].Blood,1990,76(5):887-891.

[19] MAAIKE A R,BARBARA S,SHAJI C,et al.Methionine transmethylation and transsulfuration in the piglet gastrointestinal tract[J].Proceedings of the National Academy of Science,2007,104(9):3408-3413.  

[20] GOULAS C,ZERVAS G,PAPADOPOULOS G.Effect of dietary animal fat and methionine on dairy ewes milk yield and milk composition[J].Animal Feed Science and Technology,2003,105(1/2/3/4):43-54.

[21] PREYNAT A,LAPIERRE H,THIVIERGE M C,et al.Effects of supplements of folic acid, vitamin B12, and rumen protected methionine on whole body metabolism of methionine and glucose in lactating dairy cows[J].Journal Dairy Science,92:677-689.

[22] HEGEDVS M,FEKETE S,ANDRÁSOFSZKY E,et al.Effect of methionine and its derivatives on the weight gain and protein utilization of growing rats[J].Acta Veterinaria Hungarica,1998,46(4):421-429.

[23] IZUMI K,KIKUCHI C,OKAMOTO M.Effect of rumen protected methionine on lactation performance of dairy cows[J].Asian-Australasian Journal of Animal Science,2000,13(9):1235-1238.  

[24] LEE C,GIALLONGO F,HRISTOV A N,et al.Effect of dietary protein level and rumenprotected amino acid supplementation on amino acid utilization for milk protein in lactating dairy cows[J].Journal of Dairy Science,2015,98(3):1885-1902.  

[25] MOORE L D,LE T,FAN G.DNA methylation and its basic function[J].Neuropsychopharmacology Official Publication of the American College of Neuropsychopharmacology,2013,38(1):23-38.  

[26] FISCHLE W,WANG Y M,ALLIS C D.Histone and chromatin cross-talk[J].Current Opinion in Cell Biology,2003,15(2):172-183.  

[27] TURBERVILLE C,CRADDOCK V M.Methylation of nuclear proteins by dimethylnitrosamine and by methionine in the rat in vivo[J].Biochemical Journal,1971,124(4):725-739.  

[28] MATO J M,ALVAREZ L,ORTIZ P,et al.S-adenosylmethionine synthesis:molecular mechanisms and clinical implications[J].Pulmonary Pharmacology & Therapeutics,1997,73(3):265-280.  

[29] FRIEDEL H A,GOA K L,BENFIELD P.S-adenosyl-l-methionine.A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism[J].Drugs,1989,38(3):389-416.  

[30] POTTER J D.Methyl supply,methyl metabolizing enzymes and colorectal neoplasia[J].Journal of Nutrition,2002,132(8):2410-2412.

[31] PASCALE R M,SIMILE M M,MIGLIO M D,et al.Chemoprevention of hepatocarcinogenesis:S-adenosyl-L-methionine[J].Alcohol,2002,27(3):193-198.  

[32] KRAZ S,SENGUL T.Relationship between abdominal fat and methionine deficiency in broilers[J].Czech Journal of Animal Science 2005,50(8):362-368.

[33] ELSHORBAGY A K,VALDIVIA-GARCIA M, MATTOCKS D A,et al.Cysteine supplementation reverses methionine restriction effects on rat adiposity:significance of stearoylcoenzyme A desaturase[J].Journal of Lipid Research,2011,52(1):104-112.  

[34] WALDROUP P W,M A MOTL,F YAN,et al.Effects of betaine and choline on response to methionine supplementation to broiler diets formulated to industry standards[J].Journal of Applied Poultry Research,2006,15:58-71

[35] NICULESCU M D,ZEISEL S H.Diet,methyl donors and DNA methylation:interactions between dietary folate,methionine and choline[J].Journal of Nutrition,2002,132(8):2333S-2335S.

[36] THOMAS T,THOMAS T J.Polyamines in cell growth and cell death:molecular mechanisms and therapeutic applications[J].Cellular and Molecular Life Science,2001,58(2):244-58.  

[37] LANDAU G,BERCOVICH Z,PARK M H,et al.The role of polyamines in supporting growth of mammalian cells is mediated through their requirement for translation initiation and elongation[J].Journal of Biological Chemistry,2010,285(17):12474-12481.  

[38] MANDAL S,MANDAL A,JOHANSSON H E,et al.Depletion of cellular polyamines,spermidine and spermine,causes a total arrest in translation and growth in mammaliancells[J].Proceedings of the National Academy of Sciences of the United States of America,2013,110(6):2169-2174.  

[39] YATIN M.Polyamines in living organisms[J].Journal of Cell and Molecular Biology,2002,1:57-67.

[40] CAI J,MAO Z,HWANG J J,et al.Differential expression of methionine adenosyltransferase genes influences the rate of growth of human hepatocellular carcinoma cells[J].Cancer Research,1998,58(7):1444-1450.

[41] FINKELSTEIN J D.Methionine metabolism in mammals[J].Journal of Nutritional Biochemistry,1990,1(5):228-237.  

[42] KRAMER D L,SUFRIN J R,PORTER C W.Relative effects of S-adenosylmethionine depletion on nucleic acid methylation and polyamine biosynthesis[J].Biochemical Journal,1987,247(2):259-265.  

[43] SZABÓ C.Hydrogen sulphide and its therapeutic potential[J].Nature Reviews Drug Discovery,2007,6(11):917-935.  

[44] LOWICKA E,BELTOWSKI J.Hydrogen sulfide (H2S)-the third gas of interest for pharmacologists[J].Pharmacological Reports,2007,59(1):4-24.

[45] BENAVIDES G A,SQUADRITO G L,MILLS R W,et al.Hydrogen sulfide mediates the vasoactivity of garlic[J].Proceedings of the National Academy of Sciences of theUnited States of America,2007,104(46):17977-17982.  

[46] LU S C.Regulation of hepatic glutathione synthesis[J].Seminars in Liver Disease,1998,18(4):331-343.  

[48] GREK C L,ZHANG J,MANEVICH Y,et al.Causes and consequences of cysteine S-glutathionylation[J].Journal of Biological Chemistry,2013,288(37):26497-26504.  

[49] CASTELLANO R,PERRUCHOT M H,CONDE-AGUILERA J A,et al.A methionine deficient diet enhances adipose tissue lipid metabolism and alters anti-oxidant pathways in young growing pigs[J].PLoS One,2015,10(7):e0130514.

[50] RIEDIJK M A,STOLL B,CHACKO S,et al.Methionine transmethylation and transsulfuration in the piglet gastrointestinal tract[J].Proceedings of the National Academy of Sciences of the United States of America,2007,104(9):3408-3413.  

[51] KIM Y G,KIM S K,KWON J W,et al.Effects of cysteine on amino acid concentrations and transsulfuration enzyme activities in rat liver with protein-calorie malnutrition[J].Life Sciences,2003,72(10):1171-1181.  
文章导航

/