综述 Review

黄酮类化合物的免疫调节作用及机制

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  • 沈阳农业大学畜牧兽医学院, 沈阳 110000
杨杰(1993-),女,河北沧州人,硕士研究生,研究方向为兽医药理与毒理学。E-mail:15802443206@163.com

收稿日期: 2017-06-06

  网络出版日期: 2017-12-04

基金资助

国家自然科学基金(31402252);沈阳农业大学青年基金(20131001)

Immune Regulation Function of Flavonoids and Its Mechanisms

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  • College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110000, China

Received date: 2017-06-06

  Online published: 2017-12-04

摘要

黄酮类化合物广泛分布于自然界中,具有抗炎、抗菌、抗病毒、抗肿瘤、抗氧化等多种生物活性。近年来的临床研究和试验表明,黄酮类化合物对机体免疫系统也具有重要的调节作用,主要通过影响免疫器官、细胞免疫、体液免疫和非特异性免疫以及免疫相关信号传导通路[核转录因子-κB(NF-κB)、Toll样受体(TLR)和丝裂原活化蛋白激酶(MAPK)信号通路]来发挥免疫调节作用。本文通过查阅国内外文献针对黄酮类化合物对动物机体的免疫调节作用及其分子作用机制相关研究进行了综述,以期为揭示黄酮类化合物免疫调节作用机制以及为兽医临床免疫调节中药的开发提供研究思路和方法。

本文引用格式

杨杰, 沙金丹, 高翔, 林思彤, 孙婷婷, 田春莲, 刘明春 . 黄酮类化合物的免疫调节作用及机制[J]. 动物营养学报, 2017 , 29(12) : 4295 -4300 . DOI: 10.3969/j.issn.1006-267x.2017.12.008

Abstract

Flavonoids compounds are widespread in nature and have a variety of biological functions such as anti-inflammatory, antibacterial, antiviral, antitumor, antioxygenation and so on. In recent years, clinical studies and experiments have showed that flavonoids also play an important role in immune regulation. Flavonoids are able to express immune regulation by affecting immune organ, cellular immunity, humoral immunity and nonspecific immunity, and the immune related signal pathways[nuclear factor-kappa B (NF-κB), Toll like receptor and mitogen-activated protein kinase (MAPK) signaling pathway]. In order to provide research methods and ideas for the research and development of traditional medicineand veterinary clinical immunology and the research of the immune regulation of flavonoids, we reviewed the immune regulation effect and mechanism of flavonoids on animals according to domestic and foreign literatures.

参考文献

[1] 王长远,吴洪奎,于长青,等.黄酮类化合物研究进展[J].黑龙江八一农垦大学学报,2007,19(2):75-78.

[2] SAKAI T,KOGISO M.Soy isoflavones and immunity[J].The Journal of Medical Investigation,2008,55(3):167-173.

[3] RASOULI E,JAHANIAN R.Improved performance and immunological responses as the result of dietary genistein supplementation of broiler chicks[J].Animal,2015,9(9):1473-1480.  

[4] KAMBOH A A,HANG S Q,KHAN M A,et al.In vivo immunomodulatory effects of plant flavonoids in lipopolysaccharide-challenged broilers[J].Animal,2016,10(10):1619-1625.  

[5] 朱国超,陈知水.染料木黄酮的免疫调节作用及其在器官移植中的应用[J].细胞与分子免疫学杂志,2006,22(5):689-691.

[6] 曹柏营,姜秀娟,戚颖欣,等.藤本豆豆荚总黄酮对小鼠免疫功能的影响[J].食品与机械,2017,33(1):158-162.

[7] 张锦玥,林诗宇,赵瑾,等.竹叶黄酮对免疫抑制肉鸡生产性能和免疫功能的影响[J].四川农业大学学报,2015,33(3):314-318.

[8] 梁英,任成财,姜宁,等.黄芩黄酮对肉仔鸡生长性能和免疫功能的影响[J].动物营养学报,2011,23(8):1409-1414.

[9] 朱志宁,郝振荣,王明,等.大豆异黄酮对高产奶牛泌乳后期乳腺肥大细胞分泌肿瘤坏死因子-α和表面型免疫球蛋白A水平的影响[J].动物营养学报,2011,23(1):112-121.

[10] 赵萌,郁建生,郁建平,等.藤茶总黄酮对仔猪血清生化指标及免疫功能的影响[J].中国畜牧兽医,2016,43(5):1221-1225.

[11] 严茂祥,陈芝芸,项柏康,等.金针菇多糖对小鼠血清溶血素产生及抗体形成细胞的影响[J].中医药信息,2003,20(5):56-57,64.

[12] 刘哲慧,张琳.水芹总黄酮对免疫抑制小鼠免疫功能的影响[J].中国中医药科技,2016,23(4):423-425.

[13] 冯欣欣,于文会,柏慧敏,等.沙棘黄酮抗衰老作用及对大鼠非特异性免疫功能的影响研究[J].中兽医医药杂志,2015(5):5-9.

[14] 占今舜,苏效双,刘明美,等.日粮中添加苜蓿黄酮对奶牛血液生化指标、抗氧化性能和免疫的影响[J].中国农业大学学报,2017,22(5):66-74.

[15] ZHAN J S,LIU M M,SU X S,et al.Effects of alfalfa flavonoids on the production performance,immune system,and ruminal fermentation of dairy cows[J].Asian-Australasian Journal of Animal Sciences,2017,30(10):1416-1424.  

[16] 李树义,赵志强,张庆波,等.黄芪桂枝五物汤中总黄酮对小鼠免疫功能影响的体外研究[J].中国药理学通报,2014,36(3):432-434.

[17] NASR-BOUZAIENE N,SASSI A,BEDOU A,et al.Immunomodulatory and cellular antioxidant activities of pure compounds from Teucrium ramosissimum desf[J].Tumor Biology,2016,37(6):7703-7712.  

[18] 木其尔,王贵,敖长金,等.沙葱黄酮对肉羊外周血淋巴细胞转化率和凋亡率的影响[J].动物营养学报,2017,29(3):866-873.

[19] 赵春艳.沙葱中黄酮类化合物的分离纯化、结构鉴定及其对小鼠免疫抗氧化机能影响的研究[D].博士学位论文.呼和浩特:内蒙古农业大学,2008.

[20] 古秋莉,黄聪琳,姜华.镰形棘豆黄酮苷元对免疫抑制小鼠非特异免疫功能的影响[J].方药药理研究,2016,29(4):14-16.

[21] 黄伟,陈绍红,刘铀,等.构树总黄酮对免疫抑制小鼠免疫功能的影响[J].中国现代应用药学,2017,34(1):8-11.

[22] WILLIAMS A R,KLAVER E J,LAAN L C,et al.Co-operative suppression of inflammatory responses in human dendritic cells by plant proanthocyanidins and products from the parasitic nematode Trichuris suis[J].Immunology,2017,150(3):312-328.  

[23] HUANG R Y,YU Y L,CHENG W C,et al.Immunosuppressive effect of quercetin on dendritic cell activation and function[J].Journal of Immunology,2010,184(12):6815-6821.  

[24] ZHANG K,GE Z Z,XUE Z Y,et al.Chrysin suppresses human CD14+ monocyte-derived dendritic cells and ameliorates experimental autoimmune encephalomyelitis[J].Journal of Neuroimmunology,2015,288:13-20.

[25] WEI J,BHATT S,CHANG L M,et al.Isoflavones,genistein and daidzein,regulate mucosal immune response by suppressing dendritic cell function[J].PLoS One,2012,7(10):e47979.

[26] VALENTOVÁ K,ŠÍMA P,RYBKOVÁ Z,et al.(Anti)mutagenic and immunomodulatory properties of quercetin glycosides[J].Journal of the Science of Food and Agriculture,2016,96(5):1492-1499.  

[27] MAATOUK M,ELGUEDER D,MUSTAPHA N,et al.Effect of heated naringenin on immunomodulatory properties and cellular antioxidant activity[J].Cell Stress and Chaperones,2016,21(6):1101-1109.  

[28] MORIMOTO M,TAKAGI Y,HIGASHI N,et al.Orally administered rutin inhibits the gene expression of Th2 cytokines in the gut and lung in aged mice[J].Journal of Veterinary Medical Science,2011,73(10):1257-1263.  

[29] HAGHMORAD D,MAHMOUDI M B,SALEHIPOUR Z,et al.Hesperidin ameliorates immunological outcome and reduces neuroinflammation in the mouse model of multiple sclerosis[J].Journal of Neuroimmunology,2017,302:23-33.

[30] LI Q T,VERMA I M.NF-κB regulation in the immune system[J].Nature Reviews Immunology,2002,2(10):725-734.  

[31] LIN M,LI L,LI L P,et al.The protective effect of baicalin against renal ischemia-reperfusion injury through inhibition of inflammation and apoptosis[J].BMC Complementary and Alternative Medicine,2014,14(1):19.

[32] XIE X W.Liquiritigenin attenuates cardiac injury induced by high fructose-feeding through fibrosis and inflammation suppression[J].Biomedicine & Pharmacotherapy,2017,86:694-704.

[33] LI X,LIU H C,YAO Q Y,et al.Quercetin protects mice from ConA-induced hepatitis by inhibiting HMGB1-TLR expression and down-regulating the nuclear factor kappa B pathway[J].Inflammation,2016,39(1):96-106.  

[34] LIU B,XU C,WU X,et al.Icariin exerts an antidepressant effect in an unpredictable chronic mild stress model of depression in rats and is associated with the regulation of hippocampal neuroinflammation[J].Neuroscience,2015,294:193-205.

[35] 邵丽飞.皮质酮启动增强小胶质细胞免疫炎症机制初探及淫羊藿黄酮类成分干预研究[D].硕士学位论文.南京:南京大学,2017.

[36] 杨永峰,申焕君,姜泓,等.Toll样受体4介导的抗病毒固有免疫研究进展[J].细胞与分子免疫学杂志,2016,32(6):854-858.

[37] WANG W P,XIA T S,YU X P.Wogonin suppresses inflammatory response and maintains intestinal barrier function via TLR4-MyD88-TAK1-mediated NF-kappa B pathway in vitro[J].Inflammation Research,2015,64(6):423-431.  

[38] WIDMANN C,GIBSON S,JARPE M B,et al.Mitogen-activated protein kinase:conservation of a three-kinase module from yeast to human[J].Physiological Review,1999,79(1):143-180.

[39] DONG W,WEI X,ZHANG F,et al.A dual character of flavonoids in influenza A virus replication and spread through modulating cell-autonomous immunity by MAPK signaling pathways[J].Scientific Reports,2014,4:7237.

[40] ZHANG R H,AI X,DUAN Y J,et al.Kaempferol ameliorates H9N2 swine influenza virus-induced acute lung injury by inactivation of TLR4/MyD88-mediated NF-κB and MAPK signaling pathways[J].Biomedicine & Pharmacotherapy,2017,89:660-672.

[41] ZHANG Y,ZHANG L,ZHANG Y,et al.The protective role of liquiritin in high fructose-induced myocardial fibrosis via inhibiting NF-κB and MAPK signaling pathway[J].Biomedicine & Pharmacotherapy,2016,84:1337-1349.

[42] JIANG F,GUAN H N,LIU D Y,et al.Flavonoids from sea buckthorn inhibit the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages through the MAPK and NF-κB pathways[J].Food and Function,2017,8(3):1313-1322.  
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