综述 Review

哺乳动物雷帕霉素靶蛋白生物学作用及机制

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  • 1. 内江师范学院生命科学学院, 长江上游鱼类资源保护与利用四川省重点实验室, 内江 641100;
    2. 四川农业大学动物科技学院, 成都 611130
袁登越(1987-),女,云南大理人,助教,硕士研究生,从事分子营养研究。E-mail:yuandengyue@163.com

收稿日期: 2017-07-18

  网络出版日期: 2018-02-02

基金资助

国家自然科学青年基金(31402305);内江师范学院校级科研项目(P016037)

Mammalian Target of Rapamycin: Biological Functions and Mechanisms

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  • 1. College of Life Science, Neijiang Normal University, Key Laboratory of Sichuan Province for Fishes Conservation and Utilization in the Upper Reaches of the Yangtze River, Neijiang 641100, China;
    2. College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China

Received date: 2017-07-18

  Online published: 2018-02-02

摘要

哺乳动物雷帕霉素靶蛋白(mTOR)是一种高度保守的蛋白激酶,在动物的摄食、脂质和蛋白质合成、细胞自噬和衰老等方面都发挥了重要的生理作用,已成为当前生物学研究的一大热点。本文就mTOR的结构、组织分布和生理功能及作用机制进行了综述,以期为研究mTOR信号通路的作用机制提供一定的参考。

本文引用格式

袁登越, 吴源冰, 林方军, 覃川杰, 李志琼 . 哺乳动物雷帕霉素靶蛋白生物学作用及机制[J]. 动物营养学报, 2018 , 30(2) : 484 -490 . DOI: 10.3969/j.issn.1006-267x.2018.02.011

Abstract

Mammalian target of rapamycin (mTOR) is a highly conserved protein kinase. mTOR plays a crucial role in food intake, lipogenesis and protein synthesis, autophagy and aging, so the physiological functions of mTOR becomes one of research highlights. This paper reviewed the structure, tissue distribution, physiological functions and mechanism of mTOR, with the aim of providing a valuable reference for mechanism of mTOR signaling pathways.

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