综述 Review

壳聚糖及其衍生物的抗氧化应激和抗炎症作用机制

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  • 内蒙古农业大学动物科学学院, 呼和浩特 010018
郑亚光(1990-),男,内蒙古包头人,博士研究生,从事动物矿物质与维生素营养的研究。E-mail:zhengyaguangg@163.com

收稿日期: 2017-11-14

  网络出版日期: 2018-05-06

基金资助

国家自然科学基金(31672463)

Anti-Oxidative Stress and Anti-Inflammatory Mechanism of Chitosan and Its Derivatives

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  • College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China

Received date: 2017-11-14

  Online published: 2018-05-06

摘要

壳聚糖及其衍生物是通过酶和酸性水解过程降解甲壳素的产物,由于壳聚糖的生物相容性和无毒性,使其具有潜在的生物应用价值。本文主要综述了壳聚糖及其衍生物的抗氧化和抗炎症作用,并从体内免疫调节因子、核因子κB(NF-κB)信号通路、丝裂原活化蛋白激酶(MAPK)信号通路和调节脂类代谢的角度综述了其可能的机理,为壳聚糖及其衍生物进一步的开发和利用提供了理论依据。

本文引用格式

郑亚光, 闫素梅, 史彬林, 张博綦, 赵艳丽 . 壳聚糖及其衍生物的抗氧化应激和抗炎症作用机制[J]. 动物营养学报, 2018 , 30(5) : 1633 -1638 . DOI: 10.3969/j.issn.1006-267x.2018.05.004

Abstract

Chitosan and its derivatives are the products of degradation of chitin by enzymes and acidic hydrolysis. Due to the biocompatibility and non-toxicity of chitosan, it has the potential value in biological application. This article reviews the anti-oxidation and anti-inflammatory effects of chitosan and its derivatives, the possible mechanism is summarized from nuclear factor-κB (NF-κB) signaling pathway, mitogen-activated protein kinases (MAPK) signaling pathway, immunomodulatory factor and lipid metabolism, providing a theoretical basis for its development and utilization.

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