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三丁酸甘油酯对动物生长和肠道屏障功能的影响及其作用机制

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  • 1. 广东溢多利生物科技股份有限公司, 珠海 519060;
    2. 中国海洋大学, 农业部水产动物营养与 饲料重点实验室, 教育部海水养殖重点实验室, 青岛 266003
郑欣(1991-),女,湖南岳阳人,硕士研究生,从事水生动物营养与饲料研究。E-mail:392038004@qq.com

收稿日期: 2017-11-25

  网络出版日期: 2018-05-06

Effects of Tributyrin on Growth and Intestinal Barrier Function of Animals and Its Mechanism

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  • 1. Guangdong VTR Bio-Tech Co., Ltd., Zhuhai 519060, China;
    2. Key Laboratory of Aquaculture Nutriton and Feed of Ministry of Agriculture, Key Laboratory of Mariculture of Ministry of Education, Ocean University of China, Qingdao 266003, China

Received date: 2017-11-25

  Online published: 2018-05-06

摘要

三丁酸甘油酯(TB),是由4个碳原子组成的短链脂肪酸酯,为无色近油状液体,略有脂肪香味,能顺利通过胃肠道,并被缓慢分解为丁酸,进而到达肠道后端,发挥相应的生理效应。研究报道,TB能够促进肠道绒毛生长、增强营养物质的消化、维持肠道菌群平衡、增强紧密连接、促进黏蛋白分泌、提高免疫力,进而提高动物的生产性能。因此,在饲料中添加TB已成为改善动物肠道屏障功能、促进动物生长的一种营养策略,并被广泛应用于畜牧业养殖过程中。本文主要就TB在促进动物生长和维持肠道屏障功能方面的作用以及可能的作用机制进行阐述。

本文引用格式

郑欣, 徐树德, 艾庆辉, 麦康森 . 三丁酸甘油酯对动物生长和肠道屏障功能的影响及其作用机制[J]. 动物营养学报, 2018 , 30(5) : 1668 -1675 . DOI: 10.3969/j.issn.1006-267x.2018.05.009

Abstract

Tributyrin (TB) is a short chain fatty acid ester which composed of 4 carbons, it is colourless near oily liquid and has a slight fat aroma. It can be passed through the gastrointestinal tract smoothly, decomposed into butyric acid slowly, and then to the end of the intestinal, exerting physiological effects. Researches have reported that TB could enhance the digestion of nutrients, maintain the balance of intestinal flora, enhance tight junction, increase the secretion of mucin, improve intestinal immunity, finally enhancing the growth of animals. Thus, it is a nutrition strategy that supplementation TB in the diet to improve the intestinal barrier function and growth of animals, and it has been widely used in animals husbandry. The aim of this study is to outline the effects of TB on animal's growth and intestinal barrier function and it potential regulation mechanisms.

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