陈凤鸣, 陈佳亿, 彭伟, 韦良开, 李颖慧, 黄兴国 . 氧化应激对猪肠道损伤机制的研究进展[J]. 动物营养学报, 2018 , 30(8) : 2887 -2893 . DOI: 10.3969/j.issn.1006-267x.2018.08.002

[1] KOHEN R,NYSKA A.Oxidation of biological systems:oxidative stress phenomena,antioxidants,redox reactions,and methods for their quantification[J].Toxicologic Pathology,2002,30(6):620-650.  

[2] YIN J,REN W K,WU X S,et al.Oxidative stress-mediated signaling pathways:a review[J].Journal of Food Agriculture and Environment,2013,11(2):132-139.

[3] AVIELLO G,KNAUS U G.ROS in gastrointestinal inflammation:rescue or sabotage?[J].British Journal of Pharmacology,2017,174(12):1704-1718.  

[4] KATHIRIA A S,BUTCHER L D,FEAGINS L A,et al.Prohibitin 1 modulates mitochondrial stress-related autophagy in human colonic epithelial cells[J].PLoS One,2012,7(2):e31231.

[5] ADAM-VIZI V,CHINOPOULOS C.Bioenergetics and the formation of mitochondrial reactive oxygen species[J].Trends in Pharmacological Sciences,2006,27(12):639-645.  

[6] ABRAMOV A Y,SCORZIELLO A,DUCHEN M R.Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation[J].Journal of Neuroscience,2007,27(5):1129-1138.  

[7] LI Q,HARRAZ M M,ZHOU W H,et al.NOX₂ and Rac1 regulate H₂O₂-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes[J].Molecular and Cellular Biology,2006,26(1):140-154.  

[8] WEINBERG F,HAMANAKA R,WHEATON W W,et al.Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity[J].Proceedings of the National Academy of Sciences of the United States of America,2010,107(19):8788-8793.  

[9] PORPORATO P E,PAYEN V L,PÉREZ-ESCUREDO J,et al.A mitochondrial switch promotes tumor metastasis[J].Cell Reports,2014,8(3):754-766.  

[10] KIM Y S,MORGAN M J,CHOKSI S,et al.TNF-induced activation of the NOX1 NADPH oxidase and its role in the induction of necrotic cell death[J].Molecular Cell,2007,26(5):675-687.  

[11] PETERSON L W,ARTIS D.Intestinal epithelial cells:regulators of barrier function and immune homeostasis[J].Nature Reviews Immunology,2014,14(3):141-153.  

[12] ADDABBO F,KOWALTOWSKI A J,GOLIGORSKY M S,et al.Mitochondria and reactive oxygen species[J].Hypertension,2009,53(6):885-892.  

[13] BHATTACHARYYA A,CHATTOPADHYAY R,MITRA S,et al.Oxidative stress:an essential factor in the pathogenesis of gastrointestinal mucosal diseases[J].Physiological Reviews,2014,94(2):329-354.  

[14] GEISZT M,LEKSTROM K,BRENNER S,et al.NAD(P)H oxidase 1,a product of differentiated colon epithelial cells,can partially replace glycoprotein 91phox in the regulated production of superoxide by phagocytes[J].Journal of Immunology,2003,171(1):299-306.  

[15] BEDARD K,KRAUSE K H.The NOX Family of ROS-generating NADPH oxidases:physiology and pathophysiology[J].Physiological Reviews,2007,87(1):245-313.  

[16] ROKUTAN K,KAWAHARA T,KUWANO Y,et al.NOX enzymes and oxidative stress in the immunopathology of the gastrointestinal tract[J].Seminars in Immunopathology,2008,30(3):315-327.  

[17] KAWAHARA T,KUWANO Y,TESHIMA-KONDO S,et al.Role of nicotinamide adenine dinucleotide phosphate oxidase 1 in oxidative burst response to Toll-like receptor 5 signaling in large intestinal epithelial cells[J].Journal of Immunology,2004,172(5):3051-3058.  

[18] ROKUTAN K,KAWAHARA T,KUWANO Y,et al.NADPH oxidases in the gastrointestinal tract:a potential role of NOX1 in innate immune response and carcinogenesis[J].Antioxidants & Redox Signaling,2006,8(9/10):1573-1582.

[19] VAN DER VLIET A,TUINSTRA T J R,BAST A.Modulation of oxidative stress in the gastrointestinal tract and effect on rat intestinal motility[J].Biochemical Pharmacology,1989,38(17):2807-2818.  

[20] EDDERKAOUI M,HONG P,VAQUERO E C,et al.Extracellular matrix stimulates reactive oxygen species production and increases pancreatic cancer cell survival through 5-lipoxygenase and NADPH oxidase[J].American Journal of Physiology-Gastrointestinal and Liver Physiology,2005,289(6):G1137-G1147.

[21] GUNER Y S,OCHOA C J,WANG J,et al.Peroxynitrite-induced p38 MAPK pro-apoptotic signaling in enterocytes[J].Biochemical and Biophysical Research Communications,2009,384(2):221-225.  

[22] LINDEQUE J Z,LEVANETS O,LOUW R,et al.The involvement of metallothioneins in mitochondrial function and disease[J].Current Protein & Peptide Science,2010,11(4):292-309.  

[23] VALKO M,LEIBFRITZ D,MONCOL J,et al.Free radicals and antioxidants in normal physiological functions and human disease[J].The International Journal of Biochemistry & Cell Biology,2007,39(1):44-84.  

[24] BUCHER J R,TIEN M,AUST S D.The requirement for ferric in the initiation of lipid peroxidation by chelated ferrous iron.[J].Biochemical and Biophysical Research Communications,1983,111(3):777-784.  

[25] NEISH A S.Microbes in gastrointestinal health and disease[J].Gastroenterology,2009,136(1):65-80.  

[26] KIGERL K A,DE RIVERO VACCARI J P,DIETRICH W D,et al.Pattern recognition receptors and central nervous system repair[J].Experimental Neurology,2014,258:5-16.

[27] JONES R M,LUO L P,ARDITA C S,et al.Symbiotic lactobacilli stimulate gut epithelial proliferation via NOX-mediated generation of reactive oxygen species[J].The EMBO Journal,2013,32(23):3017-3028.  

[28] KUMAR A,WU H X,COLLIER-HYAMS L S,et al.Commensal bacteria modulate cullin-dependent signaling via generation of reactive oxygen species[J].The EMBO Journal,2007,26(21):4457-4466.  

[29] NEISH A S.Redox signaling mediated by the gut microbiota[J].Free radical research,2013,47(11):950-957.  

[30] 张庆东,张成娟,戴晔.哺乳动物肠道干细胞与Wnt信号通路研究进展[J].中国畜牧兽医,2013,40(11):121-125.

[31] VAN DER FLIER L G,CLEVERS H.Stem cells,self-renewal,and differentiation in the intestinal epithelium[J].Annual Review of Physiology,2009,71(1):241-260.  

[32] SATO T,VAN ES J H,SNIPPERT H J,et al.Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts[J].Nature,2011,469(7330):415-418.  

[33] LAMBETH J D.NOX enzymes and the biology of reactive oxygen[J].Nature Reviews Immunology,2004,4(3):181-189.  

[34] SADOK A,BOURGAREL-REY V,GATTACCECA F,et al.NOX1-dependent superoxide production controls colon adenocarcinoma cell migration[J].Biochimica et Biophysica Acta:Molecular Cell Research,2008,1783(1):23-33.  

[35] CLEVERS H.Wnt/β-catenin signaling in development and disease[J].Cell,2006,127(3):469-480.  

[36] SCHEPERS A,CLEVERS H.Wnt signaling,stem cells,and cancer of the gastrointestinal tract[J].Cold Spring Harbor Perspectives in Biology,2012,4(4):a007989.

[37] CICENAS J.The potential role of Akt phosphorylation in human cancers[J].The International Journal of Biological Markers,2008,23(1):1-9.  

[38] HE X C,ZHANG J W,TONG W G,et al.BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-β-catenin signaling[J].Nature Genetics,2004,36(10):1117-1121.  

[39] PELLEGRINET L,RODILLA V,LIU Z Y,et al.Dll1-and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells[J].Gastroenterology,2011,140(4):1230-1240.  

[40] VANDUSSEN K L,CARULLI A J,KEELEY T M,et al.Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells[J].Development,2012,139(3):488-497.  

[41] SCOVILLE D H,SATO T,HE X C,et al.Current view:intestinal stem cells and signaling[J].Gastroenterology,2008,134(3):849-864.  

[42] COANT N,MKADDEM S B,PEDRUZZI E,et al.NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon[J].Molecular and Cellular Biology,2010,30(11):2636-2650.  

[43] WONG G T,MANFRA D,POULET F M,et al.Chronic treatment with the γ-secretase inhibitor LY-411,575 inhibits β-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation[J].Journal of Biological Chemistry,2004,279(13):12876-12882.  

[44] JIA M,CHEN X,LIU J,et al.PTEN promotes apoptosis of H₂O₂ injured rat nasal epithelial cells through PI3K/Akt and other pathways[J].Molecular Medicine Reports,2018,17(1):571-579.

[45] FRE S,HUYGHE M,MOURIKIS P,et al.Notch signals control the fate of immature progenitor cells in the intestine[J].Nature,2005,435(7044):964-968.  

[46] NAKAMURA T,TSUCHIYA K,WATANABE M.Crosstalk between Wnt and notch signaling in intestinal epithelial cell fate decision[J].Journal of Gastroenterology,2007,42(9):705-710.  

[47] WANKA C,STEINBACH J P,RIEGER J.Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvation-induced cell death by up-regulating respiration and improving cellular redox homeostasis[J].Journal of Biological Chemistry,2012,287(40):33436-33446.  

[48] CHEUNG E C,ATHINEOS D,LEE P,et al.TIGAR is required for efficient intestinal regeneration and tumorigenesis[J].Developmental Cell,2013,25(5):463-477.  

[49] LUI V W Y,WONG E Y L,HO K,et al.Inhibition of c-Met downregulates TIGAR expression and reduces NADPH production leading to cell death[J].Oncogene,2011,30(9):1127-1134.  

[50] ELLENBROEK S I J,COLLARD J G.Rho GTPases:functions and association with cancer[J].Clinical & Experimental Metastasis,2007,24(8):657-672.  

[51] MYANT K B,CAMMARERI P,MCGHEE E J,et al.ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation[J].Cell Stem Cell,2013,12(6):761-773.  

[52] GVNTHER C,NEUMANN H,NEURATH M F,et al.Apoptosis,necrosis and necroptosis:cell death regulation in the intestinal epithelium[J].Gut,2013,62(7):1062-1074.  

[53] CERA K R,MAHAN D C,CROSS R F,et al.Effect of age,weaning and postweaning diet on small intestinal growth and jejunal morphology in young swine[J].Journal of Animal Science,1988,66(2):574-584.  

[54] ZHU L H,ZHAO K L,CHEN X L,et al.Impact of weaning and an antioxidant blend on intestinal barrier function and antioxidant status in pigs[J].Journal of Animal Science,2012,90(8):2581-2589.  

[55] WANG X.The expanding role of mitochondria in apoptosis[J].Genes & Development,2001,15(22):2922-2933.

[56] BUDIHARDJO I,OLIVER H,LUTTER M,et al.Biochemical pathways of caspase activation during apoptosis[J].Annual Review of Cell and Developmental Biology,1999,15(1):269-290.  

[57] RIEDL S J,SHI Y.Molecular mechanisms of caspase regulation during apoptosis[J].Nature Reviews Molecular Cell Biology,2004,5(11):897-907.  

[58] ZHU L H,CAI X,GUO Q,et al.Effect of N-acetyl cysteine on enterocyte apoptosis and intracellular signalling pathways' response to oxidative stress in weaned piglets[J].British Journal of Nutrition,2013,110(11):1938-1947.