陈慧子, 张亚南, 余凯凡, 朱伟云 . 盲肠灌注丙酸对生长猪结肠黏膜基因表达的影响[J]. 动物营养学报, 2018 , 30(8) : 3134 -3141 . DOI: 10.3969/j.issn.1006-267x.2018.08.031

[1] ZHANG G Y,HAMAKER B R.Cereal carbohydrates and colon health[J].Journal of Food Science & Biotechnology,2012,87(4):331-341.

[2] WONG J M W,DE SOUZA R,KENDALL C W C,et al.Colonic health:fermentation and short chain fatty acids[J].Journal of Clinical Gastroenterology,2006,40(3):235-243.  

[3] DEN BESTEN G,VAN EUNEN K,GROEN A K,et al.The role of short-chain fatty acids in the interplay between diet,gut microbiota,and host energy metabolism[J].Journal of Lipid Research,2013,54(9):2325-2340.  

[4] CHAMBERS E S,MORRISON D J,FROST G.Control of appetite and energy intake by SCFA:what are the potential underlying mechanisms?[J].Proceedings of the Nutrition Society,2015,74(3):328-336.  

[5] WOLEVER T M,BRIGHENTI F,ROYALL D,et al.Effect of rectal infusion of short chain fatty acids in human subjects[J].American Journal of Gastroenterology,1989,84(9):1027-1033.

[6] 刘小华,李舒梅,熊跃玲.短链脂肪酸对肠道功效及其机制的研究进展[J].肠外与肠内营养,2012,19(1):56-58.

[7] DELAERE F,DUCHAMPT A,MOUNIEN L,et al.The role of sodium-coupled glucose co-transporter 3 in the satiety effect of portal glucose sensing[J].Molecular Metabolism,2012,2(1):47-53.

[8] DE VADDER F,KOVATCHEVA-DATCHARY P,GONCALVES D,et al.Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits[J].Cell,2014,156(1/2):84-96.

[9] TODESCO T,RAO A V,BOSELLO O,et al.Propionate lowers blood glucose and alters lipid metabolism in healthy subjects[J].The American Journal of Clinical Nutrition,1991,54(5):860-865.  

[10] PSICHAS A,SLEETH M L,MURPHY K G,et al.The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents[J].International Journal of Obesity,2015,39(3):424-429.  

[11] DE SILVA A,SALEM V,LONG C J,et al.The gut hormones PYY_3-36 and GLP-1_7-36 amide reduce food intake and modulate brain activity in appetite centers in humans[J].Cell Metabolism,2011,14(5):700-706.  

[12] TEDELIND S,WESTBERG F,KJERRULF M,et al.Anti-inflammatory properties of the short-chain fatty acids acetate and propionate:a study with relevance to inflammatory bowel disease[J].World Journal of Gastroenterology,2007,13(20):2826-2832.  

[13] 李建平,秦贵信,赵志辉,等.不同脂肪源饲粮育成猪肝脏转录组差异分析[J].动物营养学报,2015,27(7):2128-2139.

[14] SIMPSON K,PARKER J,PLUMER J,et al.CCK,PYY and PP:the control of energy balance[M]//JOOST H G.Handbook of experimental pharmacology.Berlin:Springer,2012209-230.

[15] DE SILVA A,BLOOM S R.Gut hormones and appetite control:a focus on PYY and GLP-1 as therapeutic targets in obesity[J].Gut and Liver,2012,6(1):10-20.  

[16] EVDOKIMOVA V,TOGNON C E,BENATAR T,et al.IGFBP7 binds to the IGF-1 receptor and blocks its activation by insulin-like growth factors[J].Science Signaling,2012,5(255):ra92.

[17] ORTIZ DE MONTELLANO P R.Cytochrome P450:structure,mechanism,and biochemistry[M].3rd ed.Berlin:Springer,2005.

[18] BLANCO A,BLANCO G.Biological oxidations:bioenergetics[M]//BLANCO A,BLANCO G.Medical biochemistry.Amsterdam:Elsevier,2017.

[19] MEIJER K,DE VOS P,PRIEBE M G.Butyrate and other short-chain fatty acids as modulators of immunity:what relevance for health?[J].Current Opinion in Clinical Nutrition and Metabolic Care,2010,13(6):715-721.  

[20] SMITH P M,HOWITT M R,PANIKOV N,et al.The microbial metabolites,short-chain fatty acids,regulate colonic T_reg cell homeostasis[J].Science,2013,341(6145):569-573.  

[21] ARPAIA N,CAMPBELL C,FAN X Y,et al.Metabolites produced by commensal bacteria promote peripheral regulatory Tcell generation[J].Nature,2013,504(7480):451-455.  

[22] SUZUKI T.Regulation of intestinal epithelial permeability by tight junctions[J].Cellular and Molecular Life Sciences,2013,70(4):631-659.  

[23] VAN ITALLIE C M,ANDERSON J M.Architecture of tight junctions and principles of molecular composition[J].Seminars in Cell & Developmental Biology,2014,36:157-165.

[24] TEN BOKUM A M,HOFLAND L J,VAN HAGEN P M.Somatostatin and somatostatin receptors in the immune system:a review[J].European Cytokine Network,2000,11(2):161-176.

[25] CHOWERS Y,CAHALON L,LAHAV M,et al.Somatostatin through its specific receptor inhibits spontaneous and TNF-alpha-and bacteria-induced IL-8 and IL-1 beta secretion from intestinal epithelial cells[J].Journal of Immunology,2000,165(6):2955-2961.  

[26] 雷姗.生长抑素对肠上皮细胞屏障功能的保护作用及机制研究[D].博士学位论文.广州:南方医科大学,2014.

[27] BARTA P,VAN PELT C,MEN T Y,et al.Enhancement of lung tumorigenesis in a gprc5a knockout mouse by chronic extrinsic airway inflammation[J].Molecular Cancer,2012,11(1):4.

[28] DENG J,FUJIMOTO J,YE X F,et al.Knockout of the tumor suppressor gene Gprc5a in mice leads to NF-κB activation in airway epithelium and promotes lung inflammation and tumorigenesis[J].Cancer Prevention Research,2010,3(4):424-437.  

[29] COLEMAN J,BLAKE-KALFF M,DAVIES E.Detoxification of xenobiotics by plants:chemical modification and vacuolar compartmentation[J].Trends in Plant Science,1997,2(4):144-151.