李欣虹, 郑若愚, 辜彦霏, 陶思邑, 任志华, 王亚超, 邓俊良 . 玉米赤霉烯酮对体外培养鸡脾脏淋巴细胞凋亡的影响[J]. 动物营养学报, 2018 , 30(8) : 3285 -3292 . DOI: 10.3969/j.issn.1006-267x.2018.08.048

[1] KIM I H,SON H Y,CHO S W,et al.Zearalenone induces male germ cell apoptosis in rats[J].Toxicology Letters,2003,138(3):185-192.  

[2] 余增丽,张立实,吴德生.玉米赤霉烯酮对乳腺癌细胞MCF-7增殖和凋亡的影响[J].中国预防医学杂志,2005,39(5):328-331.

[3] 邓友田,袁慧.玉米赤霉烯酮毒性机理研究进展[J].动物医学进展,2007,28(2):89-92.

[4] 符达.玉米赤霉酮对SD大鼠卵巢p53基因第八外显子突变的研究[D].硕士学位论文.长沙:湖南农业大学,2005.

[5] 曹林枝.p53基因及其分子生物学作用[J].中国临床医药,2003,5(1):77-80.

[6] YU J Y,ZHENG Z H,SON Y O,et al.Mycotoxin zearalenone induces AIF-and ROS-mediated cell death through p53-and MAPK-dependent signaling pathways in RAW264.7 macrophages[J].Toxicology in Vitro,2011,25(8):1654-1663.  

[7] 马勇江,许利娜,李玉谷,等.玉米赤霉烯酮对小鼠脾淋巴细胞凋亡的影响[J].家畜生态学报,2009,30(1):52-56.

[8] 任志华,王亚超,邓俊良.脱氧雪腐镰刀菌烯醇与玉米赤霉烯酮联合暴露对体外培养鸡脾脏淋巴细胞内环境稳态的影响[J].动物营养学报,2017,29(8):2836-2842.

[9] LIANG Z,REN Z H,GAO S,et al.Individual and combined effects of deoxynivalenol and zearalenone on mouse kidney[J].Environmental Toxicology and Pharmacology,2015,40(3):686-691.  

[10] REN Z H,DENG H D,DENG Y T,et al.Effect of the Fusarium toxins,zearalenone and deoxynivalenol,on the mouse brain[J].Environmental Toxicology and Pharmacology,2016,46:62-70.

[11] 高爽,邓又天,张超,等.脱氧雪腐镰刀菌烯醇、玉米赤霉烯酮及其联合染毒对小鼠肝脏功能及肝细胞凋亡的影响[J].中国兽医学报,2015,35(12):2021-2026.

[12] REN Z H,DENG H D,DENG Y T,et al.Combined effects of deoxynivalenol and zearalenone on oxidative injury and apoptosis in porcine splenic lymphocytes in vitro[J].Experimental and Toxicologic Pathology,2017,69(8):612-617.  

[13] FOSTER K A,GALEFFI F,GERICH F J,et al.Optical and pharmacological tools to investigate the role of mitochondria during oxidative stress and neurodegeneration[J].Progress in Neurobiology,2006,79(3):136-171.  

[14] POLYAK K,XIA Y,ZWEIER J L,et al.A model for P53 induced apoptosis[J].Nature,1997,389(6648):300-305.  

[15] SPRINGER J E,NOTTINGHAM S A,MCEWEN M L,et al.Caspase-3 apoptotic signaling following injury to the central nervous system[J].Clinical Chemistry and Laboratory Medicine,2001,39(4):299-307.

[16] BUDIHARDJO I,OLIVER H,LUTTER M,et al.Biochemical pathways of caspase activation during apoptosis[J].Annual Review of Cell and Developmental Biology,1999,15:269-290.

[17] NI B,WU X,DU Y,et al.Cloning and expression of rat in apoptosis of cultured cerebellar granule neurons[J].Neuroscience,1997,17(5):1561-1569.  

[18] ZHU L,YUAN H,GUO C Z,et al.Zearalenone induces apoptosis and necrosis in porcine granulosa cells via a caspase-3-and caspase-9-dependent mitochondrial signaling pathway[J].Journal of Cellular Physiology,2012,227(5):1814-1820.  

[19] 李金龙.镉致鸡脾脏淋巴细胞凋亡机理的研究[D].硕士学位论文.沈阳:东北农业大学,2004.

[20] AYED BOUSSEMA I,BOUAZIZ C,RJIBA K,et al.The mycotoxin zearalenone induces apoptosis in human hepatocytes (HepG2) via p53-dependent mitochondrial signaling pathway[J].Toxicology in Vitro,2008,22(7):1671-1680.  

[21] BOUAZIZ C,EL DEIN O S,EL GOLLI E E,et al.Different apoptotic pathways induced by zearalenone,T-2 toxin and ochratoxin A in human hepatoma cells[J].Toxicology,2008,254(1/2):19-28.

[22] ANTONSSON B,MARTINOU J C.The Bcl-2 protein family[J].Experimental Cell Research,2000,256(1):50-57.  

[23] SEDLAK T W,OLTVAI Z N,YANG K,et al.Multiple Bcl-2 family members demonstrate selective dimerizations with Bax[J].Proceeding of the National Academy of Sciences of the United States of America,1995,92(17):7834-7838.  

[24] YUAN H,DENG Y T,YUAN L Y,et al.Gynostemma pentaphyllum protects mouse male germ cells against apoptosis caused by zearalenone via Bax and Bcl-2 regulation[J].Toxicology Mechanisms and Methods,2010,20(3):153-158.  

[25] YU Z L,ZHANG L S,WU D S,et al.Anti-apoptotic action of zearalenone in MCF-7 cells[J].Ecotoxicology and Environmental Safety,2005,62(3):441-446.